SUN Zheng yi , ZHAO Lin.
  • Orthopaedic Institute of Lanzhou Medical College. Lanzhou Gansu;;
  • P. R. China 730030;;
Tissue engineering; Tendon cells; Calcium polyphosphate fiber; Scaffold material
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OBJECTIVE: To study the feasibility of calcium polyphosphate fiber (CPPF) as the scaffold material of tendon tissue engineering. METHODS: CPPF (15 microns in diameter) were woven to form pigtail of 3 mm x 2 mm transverse area; and the tensile strength, porous ratio and permeability ratio were evaluated in vitro. Tendon cells (5 x 10(4)/ml) derived from phalangeal flexor tendon of SD rats were co-culture with CPPF scaffold or CPPF scaffold resurfaced with collagen type-I within 1 week. The co-cultured specimens were examined under optical and electric scanning microscope. RESULTS: The tensile strength of CPPF scaffolds was (122.80 +/- 17.34) N; permeability ratio was 61.56% +/- 14.57%; and porous ratio was 50.29% +/- 8.16%. CPPF had no obvious adhesive interaction with tendon cells, while CPPF of surface modified with collagen type-I showed good adhesive interaction with tendon cells. CONCLUSION: The above results show that CPPF has some good physical characteristics as scaffold of tendon tissue engineering, but its surface should be modified with organic substance or even bioactive factors.

Citation： SUN Zheng yi,ZHAO Lin.. FEASIBILITY OF CALCIUM POLYPHOSPHATE FIBER AS SCAFFOLD MATERIALS FOR TENDON TISSUE ENGINEERING IN VITRO. Chinese Journal of Reparative and Reconstructive Surgery, 2002, 16(6): 426-428. doi: Copy