LI Chun ye , CAO Dai cheng.
  • Department of Hand Surgery;;
  • Bao an People s Hospital. Shenzhen Guangdong;;
  • P.R.China 518101;;
Basic fibroblast growth factor; Vein graft conduit; Peripheral nerve defect
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OBJECTIVE To explore the effect of basic fibroblast growth factor (bFGF) combined with autogenous vein graft conduit on peripheral nerve regeneration. METHODS Fifty four New Zealand rabbits were divided into three groups. The main trunk of sciatic nerve of rabbit in one side was severed and bridged by autogenous vein. 0.2 ml bFGF solution (4,000 U/ml) was intravenously injected to the vein graft conduit as group A, the same amount of saline solution as group B, and no solution injection as group C. Microscopic examination, axon video analysis and nerve conduct velocity were performed at the 10th, 30th, and 100th day after operation. RESULTS The nerve fibers were grown into vein graft conduit in all groups at 30th after operation, they were more and regular in group A than that of group B and C, and the axon regeneration rate in group A was more than that of group B and C. CONCLUSION bFGF combined with autogenous vein graft conduit can markedly promote nerve regeneration.

Citation： LI Chun ye,CAO Dai cheng.. EXPERIMENTAL STUDY ON REPAIR OF PERIPHERAL NERVE DEFECT BY BASIC FIBROBLAST GROWTH FACTOR COMBINED WITH AUTOGENOUS VEIN GRAFT CONDUIT. Chinese Journal of Reparative and Reconstructive Surgery, 2000, 14(1): 14-16. doi: Copy