• Department of Orthopedic Surgery;;
  • the Second Clinical Medical College;;
  • China Medical University. Shenyang Liaonin;;
  • P. R. China 110003;;
Bone matrix gelatin; Intervertebral fusion; Induced osteogenesis
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OBJECTIVE To testify the inductive osteogenesis of allogeneic bone matrix gelatin (BMG) in promoting intervertebral fusion. METHODS The gelatin sponge, allogeneic BMG, decalcified bone matrix (DBM) and alcohol conserved bone were implanted respectively into the intervertebral space of rabbit, whose intervertebral discs were removed before implantation. The intervertebral spaces were evaluated by X-ray and histological examination at 4, 8, and 12 weeks after operation. RESULTS No obvious immune rejection was observed. Amounts of new bone were formed in the intervertebral spaces at 4 and 8 weeks. And complete infusion of the intervertebral spaces were appeared at 12 weeks. CONCLUSION Allogeneic BMG can promote bone fusion of intervertebral spaces through osteoinduction, which suggests that allogeneic BMP is an ideal substitute for bone replacement.

Citation： BAI Lun hao,ZHANG Yun qi,WANG Hai yi,et al.. EXPERIMENTAL STUDY ON APPLICATION OF ALLOGENEIC BONE MATRIX GELATIN IN THE INTERVERTEBRAL FUSION. Chinese Journal of Reparative and Reconstructive Surgery, 2000, 14(1): 49-51. doi: Copy