XIE Huiqi 1 , YANG Zhiming 1 , QU Yi. 2
  • Department of Orthopedic Surgery;;
  • the First University Hospital;;
  • West China University of Medical Sciences. Chengdu Sichuan;;
  • P.R.China 610041;
Cell immortalization; SV40; Telomerase; Replicative senescence; Tissue engineering
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OBJECTIVE: To explore the SV40-mediated immortalization, the related factors and their roles in cell immortalization. METHODS: The original articles about cell immortalization and replicative senescence in recent decade were reviewed. RESULTS: Cell immortalization was a multifaceted phenomenon, it was involved in viral DNA integration, activation of telomerase, inactivation of growth suppressors, and so on, and their roles were closely related. CONCLUSION: The research on cell immortalization may be expected to provide important insights into a broad range of cellular biological phenomenon, and the immortalized cells can play important roles in the research of cell engineering and tissue engineering as standard cells.

Citation： XIE Huiqi,YANG Zhiming,QU Yi.. SV40 AND CELL IMMORTALIZATION. Chinese Journal of Reparative and Reconstructive Surgery, 2000, 14(3): 170-174. doi: Copy