HuiJuan LIU 1 , ZhongShan CHEN 2 , Qin Ding 2 , Yanping Song 2
  • 1. Southern Medical University， Eye Center of PLA, Wuhan General Hospital of Guangzhou Military Command 2. Eye Center of PLA, Wuhan General Hospital of Guangzhou Military Command;
Yanping Song, Email: songyanping@medmail.com.cn
Choroid diseases/diagnosis; Choroid diseases/therapy; Disease attributes; Indocyanine green/diagnostic use; Epidemiologic factors
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Objective  To investigate the clinical characteristics of patients with polypoidal choroidal vasculopathy (PCV) from Central China . Methods  This was a retrospective study, and 403 eyes of 362 patients diagnosed as PCV by ocular fundus photography, fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA) and optical coherence tomography (OCT) were enrolled. The general clinical data, fundus manifestation and ocular fundus examinations were statistically analyzed. Results  Three hundred and sixty-two cases included 249 males (68.8%) and 113 females (31.2%). Age ranged from 45 to 91 years old, and mean age was (64.81 plusmn;9.31) years old. Bilateral lesions were observed in 41 patients (11.3%) and unilateral lesions were observed in 321 patients (88.7%)． In these 403 eyes, typical orangered lesions were observed in 162 eyes (40.2%); yellowishwhite exudate could be found in 185 eyes (45.9%); 268 eyes (66.5%) showed variable degrees of subretinal hemorrhage. Drusen was found in 23 eyes (5.7%), pigment proliferation in 20 eyes (5.0%) and fiber vascular scar in 96 eyes (23.8%). The lesions of 386 eyes (95.8%) located in macular region, 53 eyes (13.2%) in peripapillary area. Lesions presented multifoci in 67 eyes (16.6%). Three hundred and four eyes (75.4%) presented typical polypoidal lesions and 152 eyes (37.7%) with abnormal branching choroidal networks. Hemorrhagic retinal pigment epithelial detachments (PED) were found in 200 eyes (49.6%) and serous PED in 96 eyes (23.8%), both existed in 25 eyes（6.2%）. OCT showed 56 eyes (13.9%) presented cystoid dark chamber between the neurosensory retina and 109 eyes (27.0%) with double-layer sign formed by the separation of retinal pigment epithelium and Bruch prime;s membrane (27.0%). Two hundred and seventy-four eyes (68.0%) were found with conelike elevation beneath the RPE layer and 151 eyes (37.6%) with neurosensory detachment. Conclusions  In Central China, the majority of PCV patients were male, unilateral. Most PCV lesions were located in the macula. Subretinal hemorrhage, polypoidal lesions and abnormal choroidal vascular networks were common in the PCV patients. Hemorrhagic PED presented a higher ratio than serous PED.

Citation： HuiJuan LIU,ZhongShan CHEN,Qin Ding,Yanping Song. Clinical characteristics of 362 cases of polypoidal choroidal vasculopathy. Chinese Journal of Ocular Fundus Diseases, 2013, 29(4): 376-379. doi: Copy