Xuxia MENG yingjun NIU ying YANG
  • Department of Ophthalmology, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China Department of Ophthalmology, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China;
Retina/physiology; Retina/embryology; Retina/growth & development; Hypoxia-inducible factor 1, alpha subunit/physiology; Animal experimentation
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Objective To investigate the expression of hypoxia inducible factor 1(HIF1 alpha;) in rats prime; retinae during the embryonic and earlier postnatal period. Methods The retinal expression patterns of HIF-1 alpha; protein and mRNA of embryonic day 12 (E12), E16, E20, and postnatal day 1(P1) and P5 rats were determined by immunohistochemical staining and reverse transcriptionpolymerase chain reaction (RT-PCR). Results HIF-1 alpha; protein was detected in the neural epithelial layer and the pigment epithelial layer at all those 5 timepoints, with higher expression in the ganglion cell layer and the inner plexiform layer, and seems limited to the ganglion cell layer when re tina became more mature. Embryonic rat retina had higher expression of HIF-1 alpha; protein and mRNA than postnatal retina, the difference was significant (P＜0.01）. Conclusion The expression of HIF1 alpha; in rats prime;retina e differs from embryonic to earlier postnatal stages. 

Citation： Xuxia MENG yingjun NIU ying YANG. The expression of hypoxia inducible factor -1αin embryonic and postnatal rats′retinae. Chinese Journal of Ocular Fundus Diseases, 2009, 25(1): 43-46. doi: Copy