Replacement therapy of stem cells transplantation represents a potential treatment for neural retinal diseases. Despite the encouraging results in laboratory, the clinical application of cells replacement therapy is still difficult because the limitation of seed cells, immunologic rejection, oncogenicity and ethical problems, etc. Recent breakthrough in somatic reprogramming provides a promising solution overcoming these obstacles. Further researches on virus free reprogramming will make the clinical application of stem cell replacement therapy possible.
Citation： 葛坚. Somatic reprogramming:new breakthrough in researches on stem cells. Chinese Journal of Ocular Fundus Diseases, 2009, 25(4): 247-248. doi: Copy