Obiective lt;br gt;To investigate the change of the activity of proliferation in cultivated M uuml;ller cells treated by advanced glycation endoproducts (AGEs), and the effect of these changes on expression of occludin in bovine retinal vascular endothelial cells (BREC). lt;br gt;Methods lt;br gt;The cultivated M uuml;ller cells were devided into normal growth group and cultured with AGEs group. The cultured BREC were devided into 4 groups:group 1, without any medium; group 2, with normal growth M uuml;ller cell medium (MCM); group 3,MCM treated by AGEs; group 4, without cell as the control. Enzyme-linked immuno sorbent assay was used to detect the content of occludin in the medium in the 4 groups. lt;br gt;Results lt;br gt;The content of expression of occludin was the most in group 2, less in group 1, and the least in group 3. lt;br gt;Conclusion lt;br gt;AGEs may promote the abnormal proliferation of M uuml;ller cells and inhibit the expression of occludin in BREC. lt;br gt;(Chin J Ocul Fundus Dis, 2006, 22: 28-30)
Citation： YE Hui,XU Gezhi,Wang Wenji. Effects of Müller cells on expression of occludin in retinal vascular endothelial cells. Chinese Journal of Ocular Fundus Diseases, 2006, 22(1): 28-30. doi: Copy