Objective To analyze the association of human leucocyte antigen (HLA)-DRB and -DQB alleles with Eales prime; disease, and to investigate the potential immunogenetics mechanism of Eales prime; disease. Methods Gene loci of HLA-DRB and -DQB1 alleles were detected by polymerase chain reaction-sequence specific primer (PCR-SSP) in 27 Han-nationality patients with Eales prime; disease in Northern China and 30 age and sex-matched normal persons as control, then statistics package for social science (SPSS) for Windows ver 13.0 software was used to analyze the distribution features of frequency of HLA-DRB and -DQB1 alleles in the two groups. Results Compared with the control group, the frequency of HLA-DRB104 allele increased obviously in the patients with Eales prime; disease［odds ratio (OR)=3.20 ，OR 95% confidence interval（CI）=1.00-10.21, and P=0.047］. Simultaneously, no statistically significant difference of the distribution of any other DRB or DQB1 allele between the two groups was found (P gt;0.05). Conclusions In hannationality people in Northern China, DRB104 is positively associated with Eales prime; disease, suggesting that DRB104 may confer a major influence on Eales prime; disease. Turbulence of immune function begotten by infect-agents attack may occur in the individuals with Eales prime; disease due to the specific hereditary diathesis of HLA, which may cause the occurrence and development of Eales disease. (Chin J Ocul Fundus Dis, 2006, 22: 90-93)
Citation： LIU Hui,SU Guanfang,WEI Shihui,et al. Association of human leucocyte antigen-DRB and -DQB alleles with Eales′ disease. Chinese Journal of Ocular Fundus Diseases, 2006, 22(2): 90-93. doi: Copy