• Department of Ophthalmology,the First People′;
  • s Hospital of Yun nan Province, Kunming 650032,China;
Vitreoretinopathy,proliferative/drug in group therapy; Harringtonines/therapeutic use; Homoharringtonine／therapeutic use; Heparin/therapeutic use
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Objective To observe the suppressive effect of co mbi nation of tissue plasminogen activator (t-PA), heparin and homoharringtonine on the formation of proliferative vitreoretinopathy (PVR) after vitreoretinal surgery. Methods Forty-three cases (44 eyes )of complicated retinal detachment who received vitreoretinal surgery were divided into 2 g roup s.Twenty cases(20 eyes)in group A were treated by intravitreal injection of abo ve mentioned drugs at the end of operation,while no intraocular injection of drugs given in 23cases(24 eyes)in group B.The mean follow-up period was 7.9 months. Result The rate of recurrent PVR in group A was 15.8%(3 of 19),and 45.5%(10 of 22) in group B (P＜0.05). The rate of recurrent retinal detachment was 5.5%(1 of 18) in group A,an d 33.3%(7 of 21)　in group B，in group B(P＜0.05). Conclusion Combination use of the above mentioned drugs can effectively suppress the post operative recurrent PVR and lower the rate of subsequent recurrent retinal detac hment. (Chin J Ocul Fundus Dis, 2001,17:24-25)

Citation： MEI Yan,YUAN Tianguo,WANG Jie,et al.. Suppressive effect of combination of t-PA,heparin and homoharringtonine on form ation of PVR after vetreoretinal surgery. Chinese Journal of Ocular Fundus Diseases, 2001, 17(1): 24-25. doi: Copy