ZHANG Xiaowei , CHEN Danian , LUO Chengren , et al
  • Department of Ophthalmology ,The First Affiliated Hospi tal , West China University of Medical Sciences, Chengdu 610041, China ;
Retinoblastoma; Genes, suppressor, tumor; Disease models,animal; Gene expression; nm23 Gene
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Purpose To investigate nucleoside diphosphate kinase (NDPK ) expression of tumor metastasis suppressor gene nm23 in heterotransplanted model of retinoblastoma(RB) in nude mice，and analyse the correlation between the expression of nm23 gene and the formation and progression of heterotran splanted RB． Methods SP immunohistochemical method was used to detect the expression of nm23 gene product NDPK in 20 tumors of heter otransplanted RB model and normal retinal tissue． Results The negative staining of nm23/ NDPK was found in normal retinal tissue , whereas 100% expression rate in RB tumors with positive number of 48.73 plusmn;2.37． No statistical significance of the expression of nm23/ NDPK was observed between the intraocular growth phase （I～Ⅲ grade） and invasive phase （ Ⅳ～Ⅴ grade）in heterotransplantedRB tumors． Conclusion The function of nm23 gene as a tumor metastasis suppressor in heterotra nsplanted RB tumors was less prominent ,but it may play a role in carcinogen esis and progrssion of RB and may predict poor prognosis． (Chin J Ocul Fundus Dis, 2001.17:47-49)

Citation： ZHANG Xiaowei,CHEN Danian,LUO Chengren,et al. Expression of nm23 gene and its significance in heterotransplanted model of retinoblastoma in nude mice. Chinese Journal of Ocular Fundus Diseases, 2001, 17(1): 47-49. doi: Copy