Purpose To investigate the relationship between the changes of the thickness of retina in macula and the abnormalities in multifocal electroretinog rams (mERG) in diabetic retinopathy. Methods mERG and optical coherence tomography (OCT) examination were performed in 38 patients (60 eyes) with DR (phase Ⅲ～Ⅳ). The data were processed with software SPSS and line relation analysis was done. Results The response densities of N1, P1 and N2 in central 5 deg; area was significantly negative related to the thickness of neuroretina in macular fovea (correlation efficient -0.252～-0.266，P lt;0.05). The response density of N2 in central 10 deg; area was also significantly negative related to the thickness of neuroretina in macular fovea (correlation efficient -0. 332，P=0.01).There was no significant relationship between the latencies of N1 in central 5 deg;, 10 deg; area and the thickness of macula, whereares the latenc ies of P1 and N2 in central 5 deg; were negatively related to the thickness of retinal pigment epithelium in the macular fovea (correlation efficient-0.271～ - 0.322，P lt;0.05). Conclusion The changes of the thickness of neuroretina in macula may affect the local retinal function in macula, which may be revealed by the reduction of response densities in mERG in patients with diabetic retinopathy. (Chin J Ocul Fundus Dis, 2001,17:257-259)

Citation： YU Qiang,ZHANG Xin,CHEN Jingrong,et al.. Relationship between the thickness of macula and the changes of multifocal electroretinograms in diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2001, 17(4): 257-259. doi: Copy