OBJECTIVE:To investigate the transporting function of subretinal fluid in retinal pigment epithelium(RPE) of experimental retinal detachment (RD). METHODS: Twenty-seven pigmented rabbits with one eye as retinal detachment model and the other eye as control were divided into 4 groups ,ic. 7 rabbits in each group at random. The Na十-K+-ATPase activity in RPE-choroidal tissue at the detached region in both experimental and control eyes was determined at the lst,2nd,3rd and 4th week after retinal detachment,and also the ultrastructure of the RPE-choroidal tissues observed. RESULTS:The activity of Na十-K+-ATPase of experimental eyesE[(2.16士1.26)/ mu;mol(mg middot;h)]was significantly lower than that of the controis[(4.84 plusmn;1.59) mu;mol/(mg middot;h)]. The degree of decreasing activity was relieving along with increasing of the course of RD. The inward pinocytosis in RPE cells under electron-microscope was found from the 2nd week samples afterwards and becoming obvious along with increasing of the disease course. CONCLUSIONS:The outward transporting function of RPE was increased after RD,it became decreased along with increasing of the course df RD and the inward transporting function then developed.

Citation： Li Yujun,Guo Xirang.. THE CHANGES OF ACTIVITY OF Na十-K+-ATPase AND ULTRASTRUCTURES OF RPE IN EXPERIMENTAL RETINAL DETACHMEN. Chinese Journal of Ocular Fundus Diseases, 1997, 13(2): 83-85. doi: Copy