• Department of Ophthalmology,Xijing Hospital,the 4th military Medical University,Xian 710032,China;
Choroid diseases/radiotherapy; Melanoma/radiotherapy; Killer cells,lymphokine- activated
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OBJECUIVE: To observe the therapeutic efficacy of  gamma;-knife/lymphokine activated killing cells (LAK)in chorold malignant melanoma (CMM). METHODS:Five cases of CMM had keen treated by retrobulbar injection of LAK cells and  gamma;-knife irradiation at multiple sites.Ophthalmologic,imageologic, fundus fluorescein angiographic and T lymphocyte subset examinations were done before and after treatment. Tile follow-up period of this series of cases was 6-24 months. RESUILS:Thc CMM of 4 in 5 treated cases became atrophic and withered up clinically after  gamma;-kinfe/LAK therapy. Among the 4 cases,2 of them had been followed up for more than 2 years,and the other 2 for 20 and 14 months respectively. The tumor of the 5th patient wko was followed up for 6 months after treatment,reduced to 3/5 of the original size,and no blood flow was found within thee tumor mass under the clinical examination. CONCLUSION :The  gamma;-knife/LAK therapy was effective in treating CMM in saving the affected eye from being enucleated. Chin J Ocul Fundus Dis,1997,13: 96- 98）

Citation： Yang Lianghu,Zhang Ju,Yang Hua,et al.. THE THERAPEUTIC EFFICACY OF Y KNIFE/LYMPHOKINE-ACTIVATED KILLING CELLS IN MALIGNANT MELANOMA OF CHOROID. Chinese Journal of Ocular Fundus Diseases, 1997, 13(2): 96-98. doi: Copy