OBJECTIVE:To verify the safe dose of cephradine in intravitreal injection. METHODS:After injecting different doses of cephradine(100 mu;g,200 mu;g,250 mu;g,300 mu;g,400 mu;g)into vitreous cavity of different group of rabbits the activities of the retinal enzymes (SDH,LDH )on different time (Id,3d, 7d ) were determined respectively, and the histological and ultrastructural changes of retinas were also observed simuhaneously. RESULTS:The activity of rellnal SDH and LDH was found to be decreased gradually with tbe icreasing of the dosage of intravitreal cephradine. The activities of SDH and LDH were found in the lowest level on tile 3rd and lsl day,but they recover to normal levels on tile 7th day after intravitreal in}eetion in 100 mu;g,200 mu;g groups,and still lower tban normal in the other groups. Histologically,retinal edema was found both in 100 mu;g and 200 mu;g groups,but degradation of retinal cells,and loss of cones and rods were round in the 250 mu;g, 300 mu;g and 400 mu;g groups. CONCLUSION: The safe dose of intravitreal injection of cepbradlnc is 200 mu;g. （Chin J Ocul Fundus Dis,1997,13:139-142 ）

Citation： Niu Yingjun,Zhou Zhanyu,Ji Jianzhong,et al.. AN EXPERIMENTAL STUDY OF ENZYMOHISTOCHEMISTRY IN RETINA BY INTRAVITREAL INJECTION OF CEPHRADINE. Chinese Journal of Ocular Fundus Diseases, 1997, 13(3): 139-142. doi: Copy