Lin Naigang , Zhang Junjun.
  • Dept. of Ophthalmology, LSU Eye Center, Louisiana State University Medical School. NewOrleans,LA 70112--2234,U. S. A;
Retina/enzymology; Protein kinases/analysis; Immunohistochemistry; Isoenzymes/analysis; Antibodies, monoclonal; Clone cells/enzymology
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PURPOSE:To verify existance of a-,~-,and 3'-protein kinase C(PKC)subspecies and their localization in rabbit retina. METHODS: Using an immunohistoehemical technique with mono- elonal antibodies against PKC isozymes- I (a),-I[ (13),and -~[ (Y) to characterize the distribution of PKC in rabbit retina. RESULTS:There is a positive immunostaining for a-,13-,and ~-PKC in rabbit retina. The immunoreactivity of a-PKC was observed mainly in the bipolar cells of inner nuclear layer and the outer segments of photorecptors. The positive immunostaining of 13-PKC could be seen in the ganglion cells,inner plexiform layer,inner nuclear layer,and the outer segments of photoreceptors. A diffuse and weak staining of Y-PKC is recognized in the ganglion cell layer,inner plexifrom layer,inner nuclear layer, and the outer segments of photoreceptors. CONCLUSION:The protein kinase C sub- speeies-a,-~,and-'Y are present in retina which is a part of the central nervous system

Citation： Lin Naigang,Zhang Junjun.. LOCALIZATION OF PROTEIN KINASE C IN RABBIT RETINA. Chinese Journal of Ocular Fundus Diseases, 1996, 12(4): 242-244. doi: Copy