Objective To evaluate the effectiveness and safety of reduced glutathione in the treatment of acute renal failure.
Methods Twenty-three patients with acute renal failure were divided into the treatment group (n=10) and the control group (n=13) by simple randomisation. Patients in the treatment group received intravenous reduced glutathione 1200 mg daily. Patients in the control group were not treated with reduced glutathione. The therapeutic course for both groups was 4 weeks. Serum creatinine and urea nitrogen were determined before treatment as well as at the end of each of the 4 weeks. Proximal and distal renal tubular functions were evaluated at the end of the treatment. The time when clinical symptoms were improved was recorded and adverse drug reactions were monitored.
Results The durations of nausea and vomiting as well as the oliguria stage were shorter in the treatment group than in the control group. The serum creatinine level in the treatment group decreased more markedly than that in the control group. At the end of the treatment, the renal tubular function was better in the treatment group than in the control group.
Conclusion Reduced glutathione contributes to the early recovery of renal function in patients with acute renal failure. However, more high-quality and large-scale randomized controlled trials are needed.
Citation：
QIU Hongyu,TANG Wanxin,TAO Ye,MI Xuhua,XU Yuanning,HUANG Songmin. A Randomized Controlled Trial of Reduced Glutathione in the Treatment of Acute Renal Failure. Chinese Journal of Evidence-Based Medicine, 2007, 07(2): 104-107. doi:
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- 1. Liu P. Acute Renal Failure. In: Wang HY. Nephrology. 2nd eds. Beijing: People’s Medical Publishing House, 1998. 1341.
- 2. Nephrol Dial Transplant, 2006; 21(5): 1240–1247.
- 3. Chen M, Guo RS, Chen ZY, et al. The protective effect of melatonin in acute ischemia reperfusion renal injury. Chinese Journal Of Nephrology, Dialysis & Transplantation, 1999, 8(1): 27–30.
- 4. 刘平. 急性肾功能衰竭. 见: 王海燕, 主编. 肾脏病学. 第2版. 北京: 人民卫生出版社, 1998. 1341.
- 5. Nitescu N, Ricksten SE, Marcussen N, et al. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion.
- 6. Polat A, Parlakpinar H, Tasdemir S, Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Act a Histochem, 2006, 108(5): 365–371.
- 7. Schumer M, Colombel MC, Sawchuk TS, et al. Morphologic, biochemical and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol, 1992, 140: 831.
- 8. 陈敏, 郭仁寿, 陈重义, 等. 褪黑素在急性肾缺血再灌注损伤中的防治作用及其对细胞凋亡的影响. 肾脏病与透析肾移植杂志, 1999, 8(1): 27–30.
- 9. Morel G, Bonnet P, Cossec B, et al. The role of glutathione and cysteine conjugates in the nephrotoxicity of oxylene in rats. Archtoxicol, 1998, 72: 553–558.
