The original meaning of “allocation concealment” is that the statistician and the trial designer who generated the random sequence and allocation sequence should not recruit and allocate the participants for the purpose of avoiding selection bias. In the process of generating allocation sequence, combined blinding measures are so called “setting blinding”, for instance, by using “double simulation”. We use a example to describe how to perform an adequate allocation and conceal the sequence, and setting blinding. Another example is used to describe how to report the methods of randomization, allocation concealment and the effect of blinding, etc.
Citation： WU Taixiang,LIU Guajian. The Concepts, Design, Practice and Reports of Allocation Concealment and Blinding. Chinese Journal of Evidence-Based Medicine, 2007, 07(3): 222-225. doi: Copy