Clinical Evidence on the Prognosis of a Patient with Gestational Diabetes Mellitus_Chinese Journal of Evidence-Based Medicine

Authors：

LI Jun ¹ ,  WU Hui ²

1. Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China2. Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

WU Hui, Email: jundream2003@yahoo.com.cn

Keywords：

Gestational diabetes mellitus (GDM); Overt diabetes mellitus; Complication; Prognosis

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Objective　 Based on the methodology of evidence-based medicine, we explored the prognosis of a patient with gestational diabetes mellitus (GDM).
Methods　 We searched ACP Journal Club (1991 to October 2006), The Cochrane Library (Issue 4, 2006), MEDLINE (1990 to October 2006) and Chinese Biomedicine database (CBM). Cohort studies, case-control studies and case series studies involving the prognosis of patients with GDM were collected. The available evidence was critically appraised.
Results　 During the period from 6 weeks to 28 years after delivery, the incidence of type 2 diabetes mellitus appeared to vary from 2.6% to 70%. Patients with GDM suffered from an increased incidence of spontaneous premature delivery, hypertension, metabolic syndrome and vaginal infection.
Conclusion　 Patients with GDM appears to be more liable to overt diabetes mellitus, and to suffer fromspontaneous premature delivery, hypertension, metabolic syndrome and vaginal infection than women with normal glucose tolerance during pregnancy. Further studies of the long-term follow-up data from GDM trials are needed.

Citation： LI Jun,WU Hui. Clinical Evidence on the Prognosis of a Patient with Gestational Diabetes Mellitus. Chinese Journal of Evidence-Based Medicine, 2007, 07(9): 690-693. doi: Copy

1.	Goldman M, Kitzmiller, Abrams B, et al. Obsteric complication with GDM. Diabetes, 1991, 40(2): 79-82.
2.	Avery MD, Rossi MA. Gestational diabetes. J Nurse Midwifery, 1994, 39(2 Suppl): 9s-19s.
3.	Sackett DL, Straus SE, Richardson WS, et al. Chief editor. Evidence-based medicine: how to practice and teach EBM, 2nd edition. London: Churchill Livingstone. 2000.
4.	李幼平, 主编. 循证医学. 第1版. 北京: 高等教育出版社, 2003. 20-21.Li YP, Chief editor. Evidence-Based Medicine. 1st eds. Beijing: Higher Education Press, 2003. 20-21.
5.	Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care, 2002, 25(10): 1862-1868.
6.	Keshavarz M, Cheung NW, Babaee GR, et al. Gestational diabetes in iran: incidence, risk factors and pregnancy outcomes. Diabetes Res Clin Pract, 2005, 69(3): 279-286.
7.	Hedderson MM, Ferrara A, Sacks DA. Gestational diabetes mellitus and lesser degrees of pregnancy hyperglycemia: association with increased risk of spontaneous preterm birth. Obstet Gynecol, 2003, 102(4): 850-856.
8.	Lauenborg J, Hansen T, Jensen DM, et al. Increasing Incidence of Diabetes After Gestational Diabetes. A long-term follow-up in a Danish population. Diabetes Care, 2004, 27(5): 1194-1199.
9.	Lauenborg J, Mathiesen E, Hansen T, et al. The prevalence of the metabol ic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population. J Clin Endocrinol Metab, 2005, 90 (7): 4004-4010.
10.	Odar E, Wandabwa J, Kiondo P. Maternal and fetal outcome of gestational diabetes mellitus in Mulago Hospital, Uganda. Afr Health Sci, 2004, 4(1): 9-14.

1. Goldman M, Kitzmiller, Abrams B, et al. Obsteric complication with GDM. Diabetes, 1991, 40(2): 79-82.
2. Avery MD, Rossi MA. Gestational diabetes. J Nurse Midwifery, 1994, 39(2 Suppl): 9s-19s.
3. Sackett DL, Straus SE, Richardson WS, et al. Chief editor. Evidence-based medicine: how to practice and teach EBM, 2nd edition. London: Churchill Livingstone. 2000.
4. 李幼平, 主编. 循证医学. 第1版. 北京: 高等教育出版社, 2003. 20-21.Li YP, Chief editor. Evidence-Based Medicine. 1st eds. Beijing: Higher Education Press, 2003. 20-21.
5. Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care, 2002, 25(10): 1862-1868.
6. Keshavarz M, Cheung NW, Babaee GR, et al. Gestational diabetes in iran: incidence, risk factors and pregnancy outcomes. Diabetes Res Clin Pract, 2005, 69(3): 279-286.
7. Hedderson MM, Ferrara A, Sacks DA. Gestational diabetes mellitus and lesser degrees of pregnancy hyperglycemia: association with increased risk of spontaneous preterm birth. Obstet Gynecol, 2003, 102(4): 850-856.
8. Lauenborg J, Hansen T, Jensen DM, et al. Increasing Incidence of Diabetes After Gestational Diabetes. A long-term follow-up in a Danish population. Diabetes Care, 2004, 27(5): 1194-1199.
9. Lauenborg J, Mathiesen E, Hansen T, et al. The prevalence of the metabol ic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population. J Clin Endocrinol Metab, 2005, 90 (7): 4004-4010.
10. Odar E, Wandabwa J, Kiondo P. Maternal and fetal outcome of gestational diabetes mellitus in Mulago Hospital, Uganda. Afr Health Sci, 2004, 4(1): 9-14.

Chinese Journal of Evidence-Based Medicine

Clinical Evidence on the Prognosis of a Patient with Gestational Diabetes Mellitus

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