Meta-analysis on Relationship Between Helicobacter Pylori Infection and Gastric Cancer_Chinese Journal of Evidence-Based Medicine

Authors：

TIAN Wenjing ¹ ,  WANG Binyou ¹ , ZHANG Jianzhong ² , ZHAO Jingbo ¹

1. Public Health School, Harbin Medical University, Harbin 150001, China2. Department of Diagnosis, Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;

Corresponding author：

WANG Binyou, Email: zhangjianzhong@icdc.cn

Keywords：

Helicobacter pylori; Gastric cancer; Meta analysis

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To analyze the relationship between helicobacter pylori (HP) and gastric cancer.
Methods 　We searched CNKI (Jan.1995-Dec.2005) and Wangfandatabase (Jan.1995-Dec.2005). Case-control studies on relationship of helicobacter pylori infection and gastric cancer were collected. Meta-analysis method was used to sum up the odds ratio (OR) and 95%CI of these studies.
Results 　We identified 14 case-control studies with 11 studies of healthy adults versus gastric cancer patients and 4 studies of gastritis versus gastric cancer patients. The results of subgroup analyses based on patients resource showed: statistical difference was founded between healthy adults and gastric cancer patients with pooled OR 2.00 and 95%CI 1.25 to 3.20; no statistical difference was founded between gastritis patients and gastric cancer patients with pooled OR 1.54 and 95%CI 0.68 to 3.50. The results of subgroup analyses based on locations of gastric cancer showed: statistical difference was founded between the non-cardiac gastric cancer patients and the control with pooled OR 3.60 and 95%CI 1.25 to 10.36; no statistical difference was found between cardiac gastric cancer patients and control with pooled OR 0.88 and 95%CI 0.56 to 1.39.
Conclusion 　HP infection can be associated with gastric cancer, and the different conclusions of the 14 reports may be attributed to the locations of gastric cancer and the selection of controls.

Citation： TIAN Wenjing,WANG Binyou,ZHANG Jianzhong,ZHAO Jingbo. Meta-analysis on Relationship Between Helicobacter Pylori Infection and Gastric Cancer. Chinese Journal of Evidence-Based Medicine, 2006, 06(11): 833-838. doi: Copy

1.	孙秀娣, 牧人, 周有尚, 等. 中国胃癌死亡率20年变化情况分析及其发展趋势预测. 中华肿瘤杂志, 2004; 26(1): 4~9.
2.	李春, 夏冰, 杨艺, 等. TNF基因多态性与胃十二指肠疾病幽门螺杆菌感染的相关性研究. 中国免疫学杂志, 2005; 21(11): 860~863.
3.	吴炎, 张万岱, 杨海涛, 等. 幽门螺杆菌感染与胃癌部位组织类型的关系. 世界华人消化杂志, 1997; 5(8): 524~525.
4.	李东光, 高艳红, 关宏伟, 等. 幽门螺杆菌感染及其他因素在弥散型和肠型胃癌发病中的意义. 中华流行病学杂志, 1995; 16(5): 299~302.
5.	徐世平, 王孟薇, 尤纬缔. 幽门螺杆菌感染与人胃癌相关性研究. 中华消化杂志, 1997; 17(4): 211~212.
6.	孙洁, 邓长生, 黄梅芳. 幽门螺杆菌感染与胃癌的关系研究. 医学新知杂志, 1998; 8(1): 8~10.
7.	姚文庆, 逯晓波, 等. 沈阳地区胃癌血清标记物病例对照研究. 中国肿瘤, 2000; 9(6): 281~283.
8.	丁建华, 李苏平, 吴建, 等. 幽门螺杆菌与其它危险因素交互作用致胃癌关系的研究. 中国肿瘤, 2002; 11(5): 267~269.
9.	兰春慧, 冷恩仁. 幽门螺杆菌感染与胃癌发生的临床研究. 四川医学, 2000; 21(1): 22~23.
10.	陈世耀, 王吉耀, 刘天舒. 幽门螺杆菌感染与胃癌 (一项病例对照研究). 胃肠病学和肝病学杂志, 1998; 7(3): 227~229.
11.	杨婕, 胡志斌, 徐耀初, 等. IL-1B及IL-1RN基因多态性与胃癌易感性的关系. 世界华人消化杂志, 2004; 12(8): 1769~1773.
12.	俞顺章, 张作风, 俞国培, 等. 饮绿茶对胃癌、慢性胃炎发病影响的流行病学调查. 中国癌症杂志, 2001; 11(1): 41~45.
13.	李忠佑, 高长明, 丁建华, 等. 上消化道癌及亲属中幽门螺杆菌感染的流行病学调查. 中华流行病学杂志, 1999; 20(2): 88~90.
14.	蔡琳, 俞顺章, 张作风. 幽门螺杆菌感染与胃癌的关系. 肿瘤防治研究, 1999; 26(4): 247~249.
15.	蒋咏文, 王润田, 王涛, 等. 幽门螺杆菌感染与胃癌及胃部病变的多组病例对照研究. 北京大学学报 (医学版), 2001; 33(2): 160~163.
16.	方积乾. 卫生统计学. 第5版. 北京: 人民卫生出版社; 2000. 399~416.
17.	Marshall BJ, Warren JR . Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet, 1984; 1(8390): 1311–1315.
18.	Xia HHX, Wong BCY, Lam SK. Helicobacter pylori infection and gastric cancer. Asian J Surg, 2001; 24: 217–222.
19.	Wong, Shiu Kum Lam, Wai ManWong, et al. Helicobacter pylori eradication to prevent gastric cancer in a high region of China.JAMA, 2004; 291: 187–194.
20.	Pakin DM, Bray F, Ferlay J, et al. Estimating the world cancerburden: Globocan 2000. Int J cancer, 2001; 94(2): 153–156.
21.	Sun XD, Mu R, Zhou YS, et al. Analysis of mortality rate of stomach cancer and its trend in twenty years in China. Chinese Journal of Cancer Prevention and Treatment, 2004; 26(1): 4–9.
22.	Li C, Xia B, Yang Y, et al. Association of TNF gene polymorphism with Helicobacter pylori infection in Chinese patients with gastroduodenal diseases. Chinese Journal of Immunology, 2005; 21(11): 860–863.
23.	Wu Y, Zhang WD, Yang HT, et al. Relationship between HP infection and the locations and histological types of gastric carcinoma. World Chinese Journal of Digestology, 1997; 5(8): 524–525.
24.	Li DG, Gao YH, Guan HW, et al. Helicobacter pylori infection and other factors in diffuse-and intestinal type stomach carcinomas. Chinese Journal of Epidemiology, 1995; 16(5): 299–302.
25.	Xu SP, Wang MW, You WD. Study on the association between Helicobacter pylori infection and human gastric cancer. Chinese Journal of Digestion, 1997; 17(4): 211–212.
26.	Sun J, Deng CS, Huang MF. Study on Relationship between Helicobacterium pylori infection and gastric cancer. Journal of New Medicine, 1998; 8(1): 8–10.
27.	Yao WQ, Lu XB, et al. A serological case-control study of gastric cancer in Shenyang area. Bulletin of Chinese Cancer, 2000; 9(6): 281–283.
28.	Ding JH, Li SP, Wu J, et al. A study on the interactions between Helicobacter pylori and other risk factors for gastric cancer. Bulletin of Chinese Cancer, 2002; 11(5): 267–269.
29.	Lan CH, Leng ER. Clinical research on occurrence of gastric cancer and infection of helicobacter pylori. Sichuan Medical Journal, 2000; 21(1): 22–23.
30.	Chen SY, Wang JY, Liu TS. The relationship between Helicobacter pylori infection and gastric cancer: A case-control study. Chinese Journal of Gastroenterology and Hepatology, 1998; 7(3): 227–229.
31.	Yang J, Hu ZW, Xu YC, et al. Relationship between polymorphisms interleukin-1B-31 and interleukin-1 receptor antagonist gene and susceptibility to gastric cancer. Chinese Journal of Digestology, 2004; 12(8): 1769–1773.
32.	Yu SZ, Zhang ZF, Yu GP, et al. Epidemiological study of the influence of drinking green tea on gastric cancer and chronic gastritis incidence. China Oncology, 2001; 11(1): 41–45.
33.	Li ZY, Gao CM, Ding JH, et al. Study on seroprevalence of Helicobacter Pylori infection among upper digestive tract cancer patients and their kindreds. Chinese Journal of Epidemiology, 1999; 20(2): 88–90.
34.	Cai L, Yu SZ, Zhang ZF. Relationship between Helicobacter pylori infection and gastric cancer. Cancer Research on Prevention and Treatment, 1999; 26(4): 247–249.
35.	Jang YW, Wang RT, Wang T, et al. Multi groups controled study on the association of Helicobacter pylori infection with gastric cancer and stomach diseases. Journal of Beijing University (Health Sciences), 2001; 33(2): 160–163.
36.	Fang JQ. Health Statistics. 5th ed. Beijing: People’s Health Publishing House; 2000. 399–416.
37.	Eslick GD, Lim LL, Byles JE, et al. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol, 1999; 94(9): 2373–2379.
38.	Huang JQ, Sridhar S, Chen Y, et al. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology, 1998; 114(6): 1169~1179.

1. 孙秀娣, 牧人, 周有尚, 等. 中国胃癌死亡率20年变化情况分析及其发展趋势预测. 中华肿瘤杂志, 2004; 26(1): 4~9.
2. 李春, 夏冰, 杨艺, 等. TNF基因多态性与胃十二指肠疾病幽门螺杆菌感染的相关性研究. 中国免疫学杂志, 2005; 21(11): 860~863.
3. 吴炎, 张万岱, 杨海涛, 等. 幽门螺杆菌感染与胃癌部位组织类型的关系. 世界华人消化杂志, 1997; 5(8): 524~525.
4. 李东光, 高艳红, 关宏伟, 等. 幽门螺杆菌感染及其他因素在弥散型和肠型胃癌发病中的意义. 中华流行病学杂志, 1995; 16(5): 299~302.
5. 徐世平, 王孟薇, 尤纬缔. 幽门螺杆菌感染与人胃癌相关性研究. 中华消化杂志, 1997; 17(4): 211~212.
6. 孙洁, 邓长生, 黄梅芳. 幽门螺杆菌感染与胃癌的关系研究. 医学新知杂志, 1998; 8(1): 8~10.
7. 姚文庆, 逯晓波, 等. 沈阳地区胃癌血清标记物病例对照研究. 中国肿瘤, 2000; 9(6): 281~283.
8. 丁建华, 李苏平, 吴建, 等. 幽门螺杆菌与其它危险因素交互作用致胃癌关系的研究. 中国肿瘤, 2002; 11(5): 267~269.
9. 兰春慧, 冷恩仁. 幽门螺杆菌感染与胃癌发生的临床研究. 四川医学, 2000; 21(1): 22~23.
10. 陈世耀, 王吉耀, 刘天舒. 幽门螺杆菌感染与胃癌 (一项病例对照研究). 胃肠病学和肝病学杂志, 1998; 7(3): 227~229.
11. 杨婕, 胡志斌, 徐耀初, 等. IL-1B及IL-1RN基因多态性与胃癌易感性的关系. 世界华人消化杂志, 2004; 12(8): 1769~1773.
12. 俞顺章, 张作风, 俞国培, 等. 饮绿茶对胃癌、慢性胃炎发病影响的流行病学调查. 中国癌症杂志, 2001; 11(1): 41~45.
13. 李忠佑, 高长明, 丁建华, 等. 上消化道癌及亲属中幽门螺杆菌感染的流行病学调查. 中华流行病学杂志, 1999; 20(2): 88~90.
14. 蔡琳, 俞顺章, 张作风. 幽门螺杆菌感染与胃癌的关系. 肿瘤防治研究, 1999; 26(4): 247~249.
15. 蒋咏文, 王润田, 王涛, 等. 幽门螺杆菌感染与胃癌及胃部病变的多组病例对照研究. 北京大学学报 (医学版), 2001; 33(2): 160~163.
16. 方积乾. 卫生统计学. 第5版. 北京: 人民卫生出版社; 2000. 399~416.
17. Marshall BJ, Warren JR . Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet, 1984; 1(8390): 1311–1315.
18. Xia HHX, Wong BCY, Lam SK. Helicobacter pylori infection and gastric cancer. Asian J Surg, 2001; 24: 217–222.
19. Wong, Shiu Kum Lam, Wai ManWong, et al. Helicobacter pylori eradication to prevent gastric cancer in a high region of China.JAMA, 2004; 291: 187–194.
20. Pakin DM, Bray F, Ferlay J, et al. Estimating the world cancerburden: Globocan 2000. Int J cancer, 2001; 94(2): 153–156.
21. Sun XD, Mu R, Zhou YS, et al. Analysis of mortality rate of stomach cancer and its trend in twenty years in China. Chinese Journal of Cancer Prevention and Treatment, 2004; 26(1): 4–9.
22. Li C, Xia B, Yang Y, et al. Association of TNF gene polymorphism with Helicobacter pylori infection in Chinese patients with gastroduodenal diseases. Chinese Journal of Immunology, 2005; 21(11): 860–863.
23. Wu Y, Zhang WD, Yang HT, et al. Relationship between HP infection and the locations and histological types of gastric carcinoma. World Chinese Journal of Digestology, 1997; 5(8): 524–525.
24. Li DG, Gao YH, Guan HW, et al. Helicobacter pylori infection and other factors in diffuse-and intestinal type stomach carcinomas. Chinese Journal of Epidemiology, 1995; 16(5): 299–302.
25. Xu SP, Wang MW, You WD. Study on the association between Helicobacter pylori infection and human gastric cancer. Chinese Journal of Digestion, 1997; 17(4): 211–212.
26. Sun J, Deng CS, Huang MF. Study on Relationship between Helicobacterium pylori infection and gastric cancer. Journal of New Medicine, 1998; 8(1): 8–10.
27. Yao WQ, Lu XB, et al. A serological case-control study of gastric cancer in Shenyang area. Bulletin of Chinese Cancer, 2000; 9(6): 281–283.
28. Ding JH, Li SP, Wu J, et al. A study on the interactions between Helicobacter pylori and other risk factors for gastric cancer. Bulletin of Chinese Cancer, 2002; 11(5): 267–269.
29. Lan CH, Leng ER. Clinical research on occurrence of gastric cancer and infection of helicobacter pylori. Sichuan Medical Journal, 2000; 21(1): 22–23.
30. Chen SY, Wang JY, Liu TS. The relationship between Helicobacter pylori infection and gastric cancer: A case-control study. Chinese Journal of Gastroenterology and Hepatology, 1998; 7(3): 227–229.
31. Yang J, Hu ZW, Xu YC, et al. Relationship between polymorphisms interleukin-1B-31 and interleukin-1 receptor antagonist gene and susceptibility to gastric cancer. Chinese Journal of Digestology, 2004; 12(8): 1769–1773.
32. Yu SZ, Zhang ZF, Yu GP, et al. Epidemiological study of the influence of drinking green tea on gastric cancer and chronic gastritis incidence. China Oncology, 2001; 11(1): 41–45.
33. Li ZY, Gao CM, Ding JH, et al. Study on seroprevalence of Helicobacter Pylori infection among upper digestive tract cancer patients and their kindreds. Chinese Journal of Epidemiology, 1999; 20(2): 88–90.
34. Cai L, Yu SZ, Zhang ZF. Relationship between Helicobacter pylori infection and gastric cancer. Cancer Research on Prevention and Treatment, 1999; 26(4): 247–249.
35. Jang YW, Wang RT, Wang T, et al. Multi groups controled study on the association of Helicobacter pylori infection with gastric cancer and stomach diseases. Journal of Beijing University (Health Sciences), 2001; 33(2): 160–163.
36. Fang JQ. Health Statistics. 5th ed. Beijing: People’s Health Publishing House; 2000. 399–416.
37. Eslick GD, Lim LL, Byles JE, et al. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol, 1999; 94(9): 2373–2379.
38. Huang JQ, Sridhar S, Chen Y, et al. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology, 1998; 114(6): 1169~1179.

Chinese Journal of Evidence-Based Medicine

Meta-analysis on Relationship Between Helicobacter Pylori Infection and Gastric Cancer

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