Association of Human Leukocyte Antigen-DRs With Pre-eclampsia/Eclampsia: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

LIN Li ¹ , XIONG Qing ¹ , LI Youping ² , XlAO Bin ¹

1. Sichuan Provincial Hospital for Women and Children, Chengdu 610031, China2. Chinese Evidence-Based Medicine Centre, Cheng du 610041, China;

Corresponding author：

Keywords：

Pre-eclampsia/eclampsia; HLA-DR antigens; Systematic review

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Objective　 To investigate the relation of Human Leukocyte Antigen-DRs to Pre-eclampsia/eclampsia （PE/E） by reviewing the observational studies on PE/E.
Methods 　We searched the MEDLINE/PubMed, EMBASE, The Cochrane Library and CBMdisc to July 2005, by combining free text with MeSH words. We assessed the quality of included studies, extracted and analyzed data.
Results 　The odds ratio of fetal-maternal HLA-DR4 antigen frequency in case group versus control group was 2. 60 （95% CI 1.87 to 3.60） with statistical significance. The antigen frequencies of＇other fetal-maternal HLA-DRs in case and control groups were not statistically significant. The antigen frequencies of the couple HLA DRs were not statistically significant between case and control groups. We found that neither the HLA-DR sharing between the couples nor between fetus and mothers in case and control groups were statistically significant.
Conclusions 　The antigen frequencies of HLA-DRs between the couples may have no association with the development of PE/E. The fetal gene types may be related to the development of PE/E. The HLA-DR sharing in mothers and fetus and the couples may have no association with the development of PE/E.

Citation： LIN Li,XIONG Qing,LI Youping,XlAO Bin. Association of Human Leukocyte Antigen-DRs With Pre-eclampsia/Eclampsia: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2006, 06(2): 117-123. doi: Copy

1.	Ju CY,Cao YL.The comparative study on the indexes of maternaland child health between China and Japan.Journal of ShanXi Medical University,2003; 6(3):217-219.鞠超英,曹玉莲.中国和日本国妇幼保健指标的调查比较山西医科大学学报,2003;6(3):217～219.
2.	Yu ZQ,Ma CS,Chief editor.Practical Hypertensionology.Beijing:Science & Technology Press:2000.余振球,马长生,主编实用高压病学北京:科学技术出版社;2000.
3.	Ding H,Zhou LX,ZhangJP,et al.The changing trend ofeclampsia during 30 years.Chinese Journal of Perinatal Medicine,2003; 6(1):10-12.丁红,周力学,张建平,等三十年子痫的变化趋势.中华围产医学杂志,2003;6(1):10～12.
4.	Yue J.Obstetrics & Gynecology.The 6th edition.Beijing:The People’s Medical Publishing House; 2004.乐杰.妇产科学.第6版.北京:人民卫生出版社;2004.
5.	Yue J.Obstetrics & Gynecology.The 5th edition.Beijing:The People’s Medical Publishing House; 2002.乐杰.妇产科学.第5版.北京:人民卫生出版社;2002.
6.	Kilpatrick DC,Lisston WA,Jaswinka EC,et al.Histocompatibility studies in preeclampsia.J Obstet Gynecol,1993; 13(2):77.
7.	Wu QY,Zhang ZJ,Mao Y,et al.Study on association of PIH with HLA-DRB1 system.Chinese Journal of Immun ology,1997; 13(6):349-352.吴乾渝,张振钧,毛羽,等妊娠高血压综合征与HLA-DRB1关联研究.中国免疫学杂志,1997;13(6):349～352.
8.	Carreiras M,Montagnani S,Layrisse Z.Preeclampsia:a multifactorial disease resulting from the interaction of the feto-maternal HLAgenotype and HCMV infection.Am J Reprod Immunol,2002; 48 (3):176 -183.
9.	Takakuwa K,Honda K,Ishii K,et al.Studies on the HLA-DRB1genotypes in Japanese women with severe pre-eclampsia positive and negative for anticardiolipin antibody using a polymerase chain reaction-restriction fragment length polymorphism method.Hum Reprod,1999; 14(12):2980-2986.
10.	Kilpatrick DC,Liston WA,Jazwinska EC,et al.Histocompatibility studies in pre-eclampsia.Tissue Antigens,1987; 29(5):232 -236.
11.	Kilpatrick DC,Liston WA,Gibson F,et al.Association between susceptibility to pre-eclampsia within families and HLA DR4.Lancet,1989; 2(8671):1063-1065.
12.	Hoff C,Peevy K,Giattina K,et al.Maternal-fetal HLA-DR relationships and pregnancy-induced hypertension.Obstet Gyneeol,1992; 80(6):1007 -1012.
13.	Omu AE,Al-Azemi MK,Al-Qattan F,et al.Connection between human leucocyte antigens D region and T helper cytokines in preeclampsia.Arch Gynecol Obstet,2004; 269(2):79 -84.
14.	Kilpatrick DC,Gibson F,Livingston J,et al.Pre-eclampsia is associated with HLA-DR4 sharing between mother and fetus.Tissue Antigens,1990; 35(4):178-181.
15.	Simon P,Fauchet R,Pilorge M,et al.Association of HLA DR4 with the risk of recurrence of pregnancy hypertension.Kidney IntSuppl,1988; 25:S125-128.
16.	de Luca Brunori I,Battini L,Simonelli M,et al.Increased HLADR homozygosity associated with pre-eclampsia.Hum Reprod,2000; 15(8):1807-1812.
17.	Liu GC,Zhang XL,Gou WL.Study on the relationship between human leucocyte antigen and parents’ antigen sharing rate and the incidence of pregnancy induced hypertension.Chinese Journal of Obstetrics and Gynecology,2002; 37 (12):705-707.刘国成,张秀兰,苟文丽.人类白细胞抗原系统及夫妻抗原共享率与妊娠高血压综合征发病的关系.中华妇产科杂志,2002;37(12):705～707.
18.	Wilton AN,Barendse WJ,Donald JA,et al.HLA-DRB types in pre-eclampsia and eclampsia.Tissue Antigens,1991; 38 (3):137 -141.
19.	Hu X,Zhang ZJ,Yang YQ,et al.The investigation on relationship of human leukocyte antigen immmunogeneity and pregnancy induced hypertension.Chinese Journal of Obstetrics and Gynecology,1994; 29(11):654-656.胡兴,张振钧,杨珏琴,等人类组织相容性抗原免疫遗传与妊高症发病关系的探讨.中华妇产科杂志,1994;29(11):654～656.
20.	ACOG Committee on Practice Bulletins-Obstetrics.ACOG practice bulletin.Diagnosis and management ofpreeclampsia and eclampsia.Obstet Gynecol,2002; 99 (1):159-167.
21.	Dong Y.The progress on classification,diagonsis and treatment in hypertensive disorders complicating pregnancy.Chin J Obstet Gynecol,2003; 38(9):586-588.董悦.妊娠高血压疾病的分类及诊治进展.中华妇产科杂志,2003;38(9):586～588.
22.	Alderson P,Green S,Higgins JPT,editors.Cochrane Reviewers’ Handbook 4.2.2[updated March 2004][M/CD].In:The Cochrane Library,Issue 1,2004.Chichester,UK:John Wiley &Sons,Ltd.
23.	How to use the evidence:assessment and application of scientific evidence.Handbook series on preparing clinical practice guidelines.National Health and Medical Research Council,2000.Available from:URL:www.ausinfo.gov.au/general/gen_hottobuy.htm.
24.	Saftlas AF,Beydoun H,Triche E.Immunogenetic determinants of preeclampsia and related pregnancy disorders:a systematic review.Obstet Gynecol,2005; 106(1):162-172.
25.	Unander AM,Lindholm A,Olding LB.Blood transfusions generate/increase previously absent/weak blocking antibody in women with habitual abortion.Fertil Steril,1985; 44(6):766 -771.
26.	Jv ZL,Fan LA.The relationship between human leukocyte antigen and pathologic pregnancy.Chinese Journal of Obstetrics and Gynecology,1998:33(2):116-118.居中亮,范丽安.人类白细胞抗原系统与病理性妊娠的相关性中华妇产科杂志,1998;33(2):116～118.

1. Ju CY,Cao YL.The comparative study on the indexes of maternaland child health between China and Japan.Journal of ShanXi Medical University,2003; 6(3):217-219.鞠超英,曹玉莲.中国和日本国妇幼保健指标的调查比较山西医科大学学报,2003;6(3):217～219.
2. Yu ZQ,Ma CS,Chief editor.Practical Hypertensionology.Beijing:Science & Technology Press:2000.余振球,马长生,主编实用高压病学北京:科学技术出版社;2000.
3. Ding H,Zhou LX,ZhangJP,et al.The changing trend ofeclampsia during 30 years.Chinese Journal of Perinatal Medicine,2003; 6(1):10-12.丁红,周力学,张建平,等三十年子痫的变化趋势.中华围产医学杂志,2003;6(1):10～12.
4. Yue J.Obstetrics & Gynecology.The 6th edition.Beijing:The People’s Medical Publishing House; 2004.乐杰.妇产科学.第6版.北京:人民卫生出版社;2004.
5. Yue J.Obstetrics & Gynecology.The 5th edition.Beijing:The People’s Medical Publishing House; 2002.乐杰.妇产科学.第5版.北京:人民卫生出版社;2002.
6. Kilpatrick DC,Lisston WA,Jaswinka EC,et al.Histocompatibility studies in preeclampsia.J Obstet Gynecol,1993; 13(2):77.
7. Wu QY,Zhang ZJ,Mao Y,et al.Study on association of PIH with HLA-DRB1 system.Chinese Journal of Immun ology,1997; 13(6):349-352.吴乾渝,张振钧,毛羽,等妊娠高血压综合征与HLA-DRB1关联研究.中国免疫学杂志,1997;13(6):349～352.
8. Carreiras M,Montagnani S,Layrisse Z.Preeclampsia:a multifactorial disease resulting from the interaction of the feto-maternal HLAgenotype and HCMV infection.Am J Reprod Immunol,2002; 48 (3):176 -183.
9. Takakuwa K,Honda K,Ishii K,et al.Studies on the HLA-DRB1genotypes in Japanese women with severe pre-eclampsia positive and negative for anticardiolipin antibody using a polymerase chain reaction-restriction fragment length polymorphism method.Hum Reprod,1999; 14(12):2980-2986.
10. Kilpatrick DC,Liston WA,Jazwinska EC,et al.Histocompatibility studies in pre-eclampsia.Tissue Antigens,1987; 29(5):232 -236.
11. Kilpatrick DC,Liston WA,Gibson F,et al.Association between susceptibility to pre-eclampsia within families and HLA DR4.Lancet,1989; 2(8671):1063-1065.
12. Hoff C,Peevy K,Giattina K,et al.Maternal-fetal HLA-DR relationships and pregnancy-induced hypertension.Obstet Gyneeol,1992; 80(6):1007 -1012.
13. Omu AE,Al-Azemi MK,Al-Qattan F,et al.Connection between human leucocyte antigens D region and T helper cytokines in preeclampsia.Arch Gynecol Obstet,2004; 269(2):79 -84.
14. Kilpatrick DC,Gibson F,Livingston J,et al.Pre-eclampsia is associated with HLA-DR4 sharing between mother and fetus.Tissue Antigens,1990; 35(4):178-181.
15. Simon P,Fauchet R,Pilorge M,et al.Association of HLA DR4 with the risk of recurrence of pregnancy hypertension.Kidney IntSuppl,1988; 25:S125-128.
16. de Luca Brunori I,Battini L,Simonelli M,et al.Increased HLADR homozygosity associated with pre-eclampsia.Hum Reprod,2000; 15(8):1807-1812.
17. Liu GC,Zhang XL,Gou WL.Study on the relationship between human leucocyte antigen and parents’ antigen sharing rate and the incidence of pregnancy induced hypertension.Chinese Journal of Obstetrics and Gynecology,2002; 37 (12):705-707.刘国成,张秀兰,苟文丽.人类白细胞抗原系统及夫妻抗原共享率与妊娠高血压综合征发病的关系.中华妇产科杂志,2002;37(12):705～707.
18. Wilton AN,Barendse WJ,Donald JA,et al.HLA-DRB types in pre-eclampsia and eclampsia.Tissue Antigens,1991; 38 (3):137 -141.
19. Hu X,Zhang ZJ,Yang YQ,et al.The investigation on relationship of human leukocyte antigen immmunogeneity and pregnancy induced hypertension.Chinese Journal of Obstetrics and Gynecology,1994; 29(11):654-656.胡兴,张振钧,杨珏琴,等人类组织相容性抗原免疫遗传与妊高症发病关系的探讨.中华妇产科杂志,1994;29(11):654～656.
20. ACOG Committee on Practice Bulletins-Obstetrics.ACOG practice bulletin.Diagnosis and management ofpreeclampsia and eclampsia.Obstet Gynecol,2002; 99 (1):159-167.
21. Dong Y.The progress on classification,diagonsis and treatment in hypertensive disorders complicating pregnancy.Chin J Obstet Gynecol,2003; 38(9):586-588.董悦.妊娠高血压疾病的分类及诊治进展.中华妇产科杂志,2003;38(9):586～588.
22. Alderson P,Green S,Higgins JPT,editors.Cochrane Reviewers’ Handbook 4.2.2[updated March 2004][M/CD].In:The Cochrane Library,Issue 1,2004.Chichester,UK:John Wiley &Sons,Ltd.
23. How to use the evidence:assessment and application of scientific evidence.Handbook series on preparing clinical practice guidelines.National Health and Medical Research Council,2000.Available from:URL:www.ausinfo.gov.au/general/gen_hottobuy.htm.
24. Saftlas AF,Beydoun H,Triche E.Immunogenetic determinants of preeclampsia and related pregnancy disorders:a systematic review.Obstet Gynecol,2005; 106(1):162-172.
25. Unander AM,Lindholm A,Olding LB.Blood transfusions generate/increase previously absent/weak blocking antibody in women with habitual abortion.Fertil Steril,1985; 44(6):766 -771.
26. Jv ZL,Fan LA.The relationship between human leukocyte antigen and pathologic pregnancy.Chinese Journal of Obstetrics and Gynecology,1998:33(2):116-118.居中亮,范丽安.人类白细胞抗原系统与病理性妊娠的相关性中华妇产科杂志,1998;33(2):116～118.

Chinese Journal of Evidence-Based Medicine

Association of Human Leukocyte Antigen-DRs With Pre-eclampsia/Eclampsia: A Systematic Review

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