Objective To explore the risk factors of carotid artery atherosclerotic plaque in ischemic stroke patients.
Methods One hundred and forty-eight patients with ischemic stoke were allocated into two groups by ultrasonographic testing (80 with plaque and 68 without plaque). The carotid artery acoustic densitometry (IMT), blood pressure, blood glucose , blood lipid, fibriongen (FIB), c-reactive protein (CRP) were tested. First, single variable analysis was conducted and then multivariate non-condition stepwise logistic model analysis was conducted.
Results Carotid IMT, age , total cholesterol (TC), low density lipoprotein (LDL)-CH, FIB, CRP level and the incidence of hypertension and diabetes were significantly higher in ischemic stroke patients with carotid artery plaques than patients without plaques (P≤0.05); Multiple logistic regression analysis showed the most important risk factors of plaques were CRP (OR=3.546, P=0.035) and FIB (OR=1.074, P=0.012) level.
Conclusion The main risk factors of carotid atherosclerosis plaque are almost the same as atherosclerosis, such as age , hypertension ,diabetes, hyperlipidemia , high FIB and CRP level and increase in carotid IMT. CRP and FIB may play a crucial role in the development of carotid artery atherosclerosis plaque.
Citation：
LI Meng,CHEN Yangmei. Risk Factors of Carotid Artery Atherosclerosis: Plaque in Ischemic Stroke Patients. Chinese Journal of Evidence-Based Medicine, 2006, 06(5): 385-389. doi:
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Copyright © the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
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Schmidt H, Schmidt R, Niederkorn K et al. Horner S, Becsagh P, Reinhart B, Schumacher M, Weinrauch V, Kostner GM. Beta-fibrinogen gene polymorphism (C148-->T) is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study. Arterioscler Thromb Vase Biol, 1998; 18(3): 487-492.
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Smith EB, Thompson WD. Fibrin as a factor in atherogenesis. Thromb Res, 1994; 73(1): 1-19.
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Folsom AR, Eckfeldt JH, Weitzman S et al. Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Stroke, 1994; 25(1): 66-73.
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Delcker A, Diener HC, Wilhelm H. Influence of vascular risk factors for atherosclerotic carotid artery plaque progression. Stroke, 1995; 26(11): 2016-2022.
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Howard G, Burke GL, Evans GW et al. Relations of intimal-medial thickness among sites within the carotid artery as evaluated by B-mode ultrasound. Stroke, 1994; 25(8): 1581-1587.
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Fabris F, Zanocchi M, Bo M et al. Carotid plaque, aging, and risk factors. A study of 457 subjects. Stroke, 1994; 25(6): 1133-1140.
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- 1. 华杨, 主编. 实用颈动脉与颅脑血管超声诊断学. 北京: 科学出版社; 2002. 179.
- 2. Hua Y, Chief Editor. Arteria cervicalis and intracalvarium blood vessel ultrasonographic diagnosis.Beijing: Science Press; 2002. 179.
- 3. Lowe GD. The relationship between infection, inflammation, and cardiovascular disease: an overview, Ann Periodontol. 2001; 6(1): 1-8.
- 4. Chambless LE, Folsom AR, Clegg LX et al. Carotid wall thickness is predictive of incident clinical stroke; the Arteriosclerosis Risk in Communities (ARIC) Study. Am J Epidenmiol, 2000; 151(5): 478-487.
- 5. O’Leary DH, Polak JF, Kronmal RA et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med, 1999; 340(1): 14-22.
- 6. Mazoyer E, Drouet L, Soria C et al. Risk factors and outcomes for atherothrombotic disease in French patients: the RIVAGE study. RIsque VAsculaire Group d’Etude. Thromb Res, 1999; 95(4): 163-176.
- 7. Tataru MC, Schulte H, von Eckardstein A et al. Plasma fibrinogen in relation to the severity of arteriosclerosis in patients with stable angina pectoris after myocardial infarction. Coron Artery Dis, 2001; 12(3): 157-165.
- 8. Schmidt H, Schmidt R, Niederkorn K et al. Horner S, Becsagh P, Reinhart B, Schumacher M, Weinrauch V, Kostner GM. Beta-fibrinogen gene polymorphism (C148-->T) is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study. Arterioscler Thromb Vase Biol, 1998; 18(3): 487-492.
- 9. Smith EB, Thompson WD. Fibrin as a factor in atherogenesis. Thromb Res, 1994; 73(1): 1-19.
- 10. Folsom AR, Eckfeldt JH, Weitzman S et al. Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Stroke, 1994; 25(1): 66-73.
- 11. Delcker A, Diener HC, Wilhelm H. Influence of vascular risk factors for atherosclerotic carotid artery plaque progression. Stroke, 1995; 26(11): 2016-2022.
- 12. Howard G, Burke GL, Evans GW et al. Relations of intimal-medial thickness among sites within the carotid artery as evaluated by B-mode ultrasound. Stroke, 1994; 25(8): 1581-1587.
- 13. Fabris F, Zanocchi M, Bo M et al. Carotid plaque, aging, and risk factors. A study of 457 subjects. Stroke, 1994; 25(6): 1133-1140.
