Objective To investigate the cognitive functions in people at high risk for schizophrenia.
Methods Two hundred and twenty-two people at high risk for schizophrenia and 331 normal controls were assessed with 14 neuropsychological tests.
Results The results of some neuropsychological tests in people at high risk for schizophrenia were worse than those in the normal controls. These tests included information, arithmetic, digital symbol, block design, logical memory, visual memory, Stroop test, verbal fluency, tower of Hanoi, WCST and CPT (P lt;0.01). The time for trail making test A in was longer in the group at high risk for schizophrenia than in the control group (P lt;0.05).
Conclusion People at high risk for schizophrenia have general cognitive deficits. Attention and executive function may represent the genetic endophenotype for schizophrenia.
Citation：
YAO Jing,GUO Lanting,SUN Jinhua,ZHOU Wei,WANG Qiang,MA Xiaohong,LIU Xiehe,HUANG Xuanyin,LI Tao. A Study of Cognitive Functions in People at High Risk for Schizophrenia. Chinese Journal of Evidence-Based Medicine, 2006, 06(8): 563-566. doi:
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- 1. Byrne M, Clafferty BA, Cosway R, et al. Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia. J Abnorm Psychol, 2003; 112(1): 38-48.
- 2. Gottesman II, McGue M. Mixed and mixed-up models for the transmission of schizophrenia. Minneapolis: University of Minnesota Press.1991.
- 3. Compton DM，Bachman LD，Brand D, et al. Age-associated changes in cognitive function in highly educated adults：emerging myths and realities．Int J Geriatr Psychiatry, 2000; 15(1): 75-85.
- 4. Archila A, Moreno S. Neuropsychological test performance in Auuaco Indians：an exploratory study．J Int Neuropsychol Soc, 2001; 7(4): 510-515.
- 5. Georgopoulos AP, Whang K, Georgopoulos MA, et al. Functional magnetic resonance imaging of visual object construction and shape discrimination: relations among task, hemispheric lateralization and gender. J Cogn Neurosci, 2001; 13(1): 72-89.
- 6. Chen WJ, Faraone SV. Sustained attention deficits as markers of genetic susceptibility to schizophreia. Am J Med Genet, 2000; 97: 52-57.
- 7. Hoff AL, Svetina C, Maurizio AM, et al. Familial cognitive deficits in schizophrenia. Am. J. Med. Genet., 2005; 133B: 43-49.
- 8. Akdede B, Alptekin K, Kiti A, et al. Effects of quetiapine on cognitive functions in schizophrenia.Prog. Neuropsychopharmacol. Biol. Psychiatry, 2005; 29: 233-238.
- 9. Bustini M, Stratta P, Daneluzzo E, et al. Tower of Hanoi and WCST performance in schizophrenia: problem-solving capacity and clinical correlates. J Psychiatr Res, 1999; 33(3): 285-290.
