The Value of SPIO-Enhanced MR Imaging in the Focal Hepatic Lesion Detection: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

SHUAI Dan dan , LIU Rong bo , ZHOU Xiang ping

Department of Radiology; West China Hospital; Sichuan University; Chengdu 610041; China;

Corresponding author：

Keywords：

Focal hepatic lesions; SPIO-enhanced MRI; Systematic review

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To evaluate the sensitivity and accuracy of SPIO-enhanced MR Imaging in the detection of focal hepatic lesions.
Methods 　We searched MEDLINE (1966 to 2004), EMBSAE (1984 to 2004), The Cochrane Library (Issue 1, 2004), CBMdisc (Jan.1978 to Jul. 2004), CMCC (1994 to 2004), “Radiology”, “AJR” and “European Radiology” database. Data from pharmaceutical companies and our research were also added. Related journals published from 1985 to 2003 were handsearched. Participants were clinically suspected of focal hepatic lesions. The quality of studies was assessed, and descriptive systematic review was applied to evaluate the detection sensitivity and accuracy of the imaging modality.
Results　 Ten studies (418 patients with 1 037 focal hepatic lesions) were included. Because the data of sensitivity and specificity could not be extracted from any of the 10 included studies, it was impossible to do the meta-analysis using SROC curve. The sensitivity of SPIO-enhanced MRI ranged from 66% to 100%; accuracy ranged from 76% to 97%.
Conclusions 　At present, there is no evidence to ascertain that SPIO-enhanced MRI has a considerably high accuracy in the detection of focal hepatic lesions. More studies with good methodology are needed.

Citation： SHUAI Dan dan,LIU Rong bo,ZHOU Xiang ping. The Value of SPIO-Enhanced MR Imaging in the Focal Hepatic Lesion Detection: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2005, 05(3): 237-241. doi: Copy

1.	王莉, 田建明, 陆建平. 不同场强和序列的超顺磁性氧化铁磁共振增强扫描在肝癌检出中的比较[J]. 中国医学计算机成像杂志, 2002; 8(3): 177～182.
2.	Ward J, Guthrie JA, Scott DJ, Achley J, Wilson D, Davies MH, Wyatt JI, Robinson PJ. Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis[J]. Radiology, 2000; 216(1): 154-162.
3.	Wang L, Tian JM, Lu JP. Comparative study with different field strength and sequences in detect hepatic carcinoma using superparamagnetic iron oxide enhanced MR imaging[J]. Chinese Journal of Medical Computed Imaging, 2002; 8(3):177-182.
4.	Takahama K, Amano Y, Hayashi H, Ishihara M, Kamazaki T. Detection and characterization of focal liver lesions using superparamagnetic iron oxide-enhanced magnetic resonance imaging: comparison between ferumoxides-enhanced T1-weighted imaging and delayed-phase gadolinium-enhanced T1-weighted imaging[J]. Abdom-Imaging, 2003; 28(4): 525-530.
5.	Kim YK, Kim CS, Lee YH, Kwak HS, Lee JM. Comparison of superparamagnetic iron oxide-enhanced and gadobenate dimeglumine-enhanced dynamic MRI for detection of small hepatocellular carcinomas[J]. AJR Am J Roentgenol, 2004; 182(3):1 217-1 223.
6.	Ssalamah AB, Peer GH, Schima W. Detection of focal hepatic lesions: comparison of unenhanced and SHU 555 A-enhanced MR imaging versus biphasic helical CTAP[J]. J-Magn-Reson-Imaging, 2000 ; 11(6): 665-672.
7.	Blakeborough A, Ward J, Wilson D. Hepatic lesion detection at MR imaging: a comparative study with four sequences[J]. Radiology, 1997; 203(3):759-765.
8.	Kim MJ, Kim JH, Chung JJ, Park MS, Lim JS, Oh YT. Focal hepatic lesions: detection and characterization with combination gadolinium- and superparamagnetic iron oxide-enhanced MR imaging[J]. Radiology, 2003; 228(3):719-726.
9.	Ward J, Naik KS, Guthrie JA, Wilson D, Robinson PJ. Hepatic lesion detection: comparison of MR imaging after the administration of superparamagnetic iron oxide with dual-phase CT by using alternative-free response receiver operating characteristic analysis[J]. Radiology, 1999; 210(2): 459-466.
10.	Hori M, Murakami T, Kim T, Tsuda K, Takahashi S, Okada A, Takamura M, Nakamura H. Detection of hypervascular hepatocellular carcinoma: comparison of SPIO-enhanced MRI with dynamic helical CT[J]. J Comput Assist Tomogr, 2002;26(5):701-710.

1. 王莉, 田建明, 陆建平. 不同场强和序列的超顺磁性氧化铁磁共振增强扫描在肝癌检出中的比较[J]. 中国医学计算机成像杂志, 2002; 8(3): 177～182.
2. Ward J, Guthrie JA, Scott DJ, Achley J, Wilson D, Davies MH, Wyatt JI, Robinson PJ. Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis[J]. Radiology, 2000; 216(1): 154-162.
3. Wang L, Tian JM, Lu JP. Comparative study with different field strength and sequences in detect hepatic carcinoma using superparamagnetic iron oxide enhanced MR imaging[J]. Chinese Journal of Medical Computed Imaging, 2002; 8(3):177-182.
4. Takahama K, Amano Y, Hayashi H, Ishihara M, Kamazaki T. Detection and characterization of focal liver lesions using superparamagnetic iron oxide-enhanced magnetic resonance imaging: comparison between ferumoxides-enhanced T1-weighted imaging and delayed-phase gadolinium-enhanced T1-weighted imaging[J]. Abdom-Imaging, 2003; 28(4): 525-530.
5. Kim YK, Kim CS, Lee YH, Kwak HS, Lee JM. Comparison of superparamagnetic iron oxide-enhanced and gadobenate dimeglumine-enhanced dynamic MRI for detection of small hepatocellular carcinomas[J]. AJR Am J Roentgenol, 2004; 182(3):1 217-1 223.
6. Ssalamah AB, Peer GH, Schima W. Detection of focal hepatic lesions: comparison of unenhanced and SHU 555 A-enhanced MR imaging versus biphasic helical CTAP[J]. J-Magn-Reson-Imaging, 2000 ; 11(6): 665-672.
7. Blakeborough A, Ward J, Wilson D. Hepatic lesion detection at MR imaging: a comparative study with four sequences[J]. Radiology, 1997; 203(3):759-765.
8. Kim MJ, Kim JH, Chung JJ, Park MS, Lim JS, Oh YT. Focal hepatic lesions: detection and characterization with combination gadolinium- and superparamagnetic iron oxide-enhanced MR imaging[J]. Radiology, 2003; 228(3):719-726.
9. Ward J, Naik KS, Guthrie JA, Wilson D, Robinson PJ. Hepatic lesion detection: comparison of MR imaging after the administration of superparamagnetic iron oxide with dual-phase CT by using alternative-free response receiver operating characteristic analysis[J]. Radiology, 1999; 210(2): 459-466.
10. Hori M, Murakami T, Kim T, Tsuda K, Takahashi S, Okada A, Takamura M, Nakamura H. Detection of hypervascular hepatocellular carcinoma: comparison of SPIO-enhanced MRI with dynamic helical CT[J]. J Comput Assist Tomogr, 2002;26(5):701-710.

Chinese Journal of Evidence-Based Medicine

The Value of SPIO-Enhanced MR Imaging in the Focal Hepatic Lesion Detection: A Systematic Review

Abstract Full text Figures/Tables Video References Cited by

Format

Content