Effect of Dengzhanhua Injection for Angina Pectoris: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

1. West China Medical School, Sichuan University, Chengdu 610041,China2. Department of Clinical Epidemiology & Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu 610041,China;

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Keywords：

Dengzhanhua Injection; Angina pectoris; Effectiveness; Systematic review

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Objective 　To assess the effect of Dengzhanhua Injection for angina pectoris.
Methods 　We performed an electronic search for MEDLINE (1966 to 2004), EMBASE (1974 to 2004), The Cochrane Library (Issue 4, 2004), CBM and CNKI (1980 to 2004). We included randomized controlled trials that met the inclusion and exclusion criteria and evaluated the quality of those trials and performed the meta-analysis by RevMan 4.2.7.
Results 　Eight trials were included involving 634 patients. However, they were of poor quality. The results of meta-analysis indicated that there were statistical difference on symptoms and electrocardiogram (ECG) improvements between Dengzhanhua and control group (Breviscarpine≥30 mg) with RR 1.26, 95%CI 1.11 to 1.44 and RR 1.30, 95%CI 1.14 to 1.49, respectively. However, Dengzhanhua Injection (Breviscarpine lt;30 mg) vs. basic therapy showed no statistical difference in either symptom improvement (RR 1.03, 95%CI was 0.90 to 1.18) or ECG improvement (RR 1.01, 95%CI 0.86 to 1.20). In addition, Dengzhanhua decreased the myocardial infarction attacks in one year following up (OR 0.06, 95%CI 0.01 to 0.29).
Conclusions 　Little evidence shows that Dengzhanhua is superior to simple basic therapy in the symptoms and ECG improvements as an auxiliary drug. However, this systematic review can not draw a conclusion about the effectiveness of Dengzhanhua Injection compared to simple basic therapy in the treatment of angina pectoris due to the poor quantity of included trials.

Citation： CAO Wenzhai,LAN De,ZHANG Ting,TANG Chao,WU Taixiang,LIU Guanjian. Effect of Dengzhanhua Injection for Angina Pectoris: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2005, 05(4): 317-322. doi: Copy

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20.	Chen YY, Wang ST, Zeng WS. Dengzhanhua Su relaxes the muscular ring of rat aorta[J]. New Chinese Herbal &Clinical Pharmacology,1994; 5(2): 15-19.
21.	Cardiovascular Group of the First National Internal Medical Academic Conference. Proposition on Nomination and Diagnosis of Coronary Heart Disease[J]. Chinese Journal of Cardiology, 1981; 9(1): 75.
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27.	Yang J, Li Y, Shao GY. Clinical observation on Dengzhanhua for 62 cases coronary heart disease and angina pectoris[J]. Heinongjiang Medical Journal, 2001; 25(6): 447.
28.	Nie YW, Xing TG. Clinical observation on Dengzhanhua for coronary heart disease and angina pectoris[J]. Journal of Heze Medical College, 2002; 14(2): 36-37.
29.	Tang YP, Liu Y. Clinical observation on Dengzhanhua Injection and Danshen Injection for angina pectoris[J]. Journal of Guangxi Chinese Medical College, 2001; 18(1): 33-34.
30.	Xu TW, Wang LC. Dengzhanhua Injection for UAP 17 cases[J]. Shangdong Medical Journal, 2001(6); 8: 71.
31.	Yu HW, Zhao L, Cao MR. Dengzhanhua Injection for UAP[J]. Chinese Herbal Medicine Information Journal, 2001; 8(9): 68.
32.	Wang LN, Cheng JL. Clinical observation on Dengzhanhua injection for angina pectoris[J]. Modern Combination of Chinese and Western Medicine Journal, 1999; 8(7): 1 072.
33.	Liu JP, Heather M, Lin H. Chinese medicinal herbs for chronic hepatitis B: a systematic review[J]. Chinese Journal of Evidence-Based Medicine, 2001; 1(1): 16-24.

1. 卫生部:2003年慢性疾病患病率[EB/OL]. 中国卫生统计年鉴2004, 2004.4; [引用日期2004.7.28]; 来源: URL http://61.49.18.68/statistics/digest04/s57.htm.
2. 陈一岳, 王胜涛, 曾文珊. 灯盏花素对大鼠主动脉肌环的松弛作用[J]. 中药新药与临床药理, 1994; 5(2): 15～19.
3. 第一届全国内科学术会议心血管病组. 关于冠状动脉性心脏病命名及诊断标准的建议[J]. 中华心血管杂志, 1981; 9(1): 75.
4. 国际心脏病学会和协会及世界卫生组织临床命名标准化联合专题组. 缺血性心脏病的命名及诊断标准[J]. 中华心血管杂志, 1981; 9(1): 75～76.
5. 朱效荣, 王灿东, 郭淑芬. 常规疗法加灯盏花素治疗不稳定性心绞痛疗效观察[J]. 山东医药, 2001; 41(1): 32.
6. 邢赛玲, 张小民, 刘春荣. 灯盏花素治疗不稳定型心绞痛的疗效分析[J]. 中国煤炭工业医学杂志, 2000; 3(9): 934～934.
7. 杨晶, 李颖, 邵桂英. 灯盏花素治疗冠心病心绞痛62 例临床观察[J]. 黑龙江医学, 2001; 25(6): 447.
8. 聂元文, 邢同国. 灯盏花素治疗冠心病心绞痛的疗效观察[J]. 菏泽医专学报, 2002; 14(2): 36～37.
9. 唐耀平, 刘鹰. 灯盏花素注射液、复方丹参液治疗冠心病的临床观察[J]. 广西中医学院学报, 2001; 18(1): 33～34.
10. 徐同文, 王立春. 灯盏花素注射液治疗不稳定心绞痛17 例[J]. 山东医药, 2001(6); 8: 71.
11. 于红伟, 赵亮, 曹茂荣. 灯盏花素注射液治疗不稳定性心绞痛[J]. 中国中医药信息杂志, 2001; 8(9): 68.
12. 王丽娜, 程嘉伦. 灯盏花素注射液治疗冠心病30例疗效观察. 现代中西医结合杂志, 1999; 8(7): 1 072.
13. 刘建平, Heather McIntosh, 林辉. 中草药治疗慢性乙型肝炎随机对照试验的系统评价[J]. 中国循证医学杂志, 2001; 1(1): 16～24.
14. AHA: Angina Pectoris [EB/OL]. Angina Pectoris[serial online]; [cited 2004, July 24]; Avaliable from: URL http://www.americanheart.org/presenter.jhtml?identifier=4472/.
15. Ford ES, Giles WH, Croft JB. Prevalence of nonfatal coronary heart disease among American adults[J]. Am Heart J, 2000; 139(3): 371-377.
16. Ministry of Health P.R. China: Morbidity Rate of Chronic Diseases in 2003[EB/OL]. China Health Statistics Yearbook 2004[serial online] 2004 April; [cited 2004, July 28]; Available from: URL http://61.49.18.68/statistics/digest04/s57.htm.
17. H, Shipley M, Britton A, Page M, Macfarlane P, Marmot M. Prognosis of angina with and without a diagnosis: 11 year follow up in the Whitehall Ⅱ prospective cohort study Prognosis of angina with and without a diagnosis: 11 year follow up in the Whitehall Ⅱ prospective cohort study[J]. BMJ, 2003; 10(327): 895.
18. SIGN. Drug Treatment[EB/OL]. in: Management of Stable Angina. [serial online] 2001 Dec[Cited 2004, August 2]. Available from: URL http://www.sign.ac.uk/guidelines/fulltext/32/.
19. Psaty BM, Koepsell TD, Wagner EH, LoGerfo JP, Inui TS. The relative risk of incident coronary heart disease associated wtih recently stopping the use of beta-blockers[J]. JAMA, 1990; 263(12): 1 653-1 657.
20. Chen YY, Wang ST, Zeng WS. Dengzhanhua Su relaxes the muscular ring of rat aorta[J]. New Chinese Herbal &Clinical Pharmacology,1994; 5(2): 15-19.
21. Cardiovascular Group of the First National Internal Medical Academic Conference. Proposition on Nomination and Diagnosis of Coronary Heart Disease[J]. Chinese Journal of Cardiology, 1981; 9(1): 75.
22. International Society and Association of Cardiology, WHO. Nomination and Diagnosis of Ishemic Heart Disease[J]. Chinese Journal of Cardiology, 1981; 9(1): 75-76.
23. International Conference on Harmonisation Expert Working Group: Internatioal conference on harmonization of technical requirements for registration of pharmaceuticals for human use. Guideline for good clinical practice[Z]. 1997 CFR&ICH Guidelines. 1997: Vol. 1,Barnett International/PAREXEL, PA 19063-2043, USA.
24. Aldeson P,Green S,Higgins JPT editors.Cochrane Reviews Handbook 4.2.2[Updated December 2003][M/CD].In:The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
25. Zhu XR, Wang CD, Guo SF. Study on Dengzhanhua with routine remedy for unstable angina[J]. Shandong Medicine, 2001; 41(1): 32.
26. Xing SL, Zhang XM, Liu CR. Analysis of Dengzhanhua curative effect on UAP[J]. Chinese Coal Industry Medicine Journal, 2000; 3(9): 934-934.
27. Yang J, Li Y, Shao GY. Clinical observation on Dengzhanhua for 62 cases coronary heart disease and angina pectoris[J]. Heinongjiang Medical Journal, 2001; 25(6): 447.
28. Nie YW, Xing TG. Clinical observation on Dengzhanhua for coronary heart disease and angina pectoris[J]. Journal of Heze Medical College, 2002; 14(2): 36-37.
29. Tang YP, Liu Y. Clinical observation on Dengzhanhua Injection and Danshen Injection for angina pectoris[J]. Journal of Guangxi Chinese Medical College, 2001; 18(1): 33-34.
30. Xu TW, Wang LC. Dengzhanhua Injection for UAP 17 cases[J]. Shangdong Medical Journal, 2001(6); 8: 71.
31. Yu HW, Zhao L, Cao MR. Dengzhanhua Injection for UAP[J]. Chinese Herbal Medicine Information Journal, 2001; 8(9): 68.
32. Wang LN, Cheng JL. Clinical observation on Dengzhanhua injection for angina pectoris[J]. Modern Combination of Chinese and Western Medicine Journal, 1999; 8(7): 1 072.
33. Liu JP, Heather M, Lin H. Chinese medicinal herbs for chronic hepatitis B: a systematic review[J]. Chinese Journal of Evidence-Based Medicine, 2001; 1(1): 16-24.

Chinese Journal of Evidence-Based Medicine

Effect of Dengzhanhua Injection for Angina Pectoris: A Systematic Review

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