Effect and Safety of Yinzhihuang Injection for Icteric Viral Hepatitis: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

CHEN Jun ¹ , CHEN Huiyang ¹ , LIU Zhichen ¹ , WU Taixiang ²

1. Department of Pharmacy; Shenzhen Hospital of TCM; Shenzhen 518033; China 2. Chinese Evidence-Based Medicine Center; West China Hospital; Sichuan University; Chengdu 610041; China;

Corresponding author：

Keywords：

Yinzhihuang injection; Viral hepatitis; Icterus; Systematic Review

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Objective 　To evaluate the effect and safety of Yinzhihuang injection for icteric viral hepatitis.
Methods 　We searched MEDLINE (1966 to 2005), The Cochrane Library (Issue1, 2005), CBMdisk (1978 to 2004), CMCC (1994 to 2005), CMAC (1994 to 2005), CNKI (1994 to 2005), VIP (1989 to 2004). Data were extracted by two reviewers using a designed extraction form. The quality of included trials was critically assessed. RevMan 4.2.7 was used for data analysis.
Results 　Four randomized controlled trials were included. It showed that Yinzhihuang injection could abate jaundice better than or the same as controlled western medicine in patients with hepatitis (WMD 19.70, 95%CI 32.69 to 6.71 and WMD 1.27, 95%CI 3.08 to 0.54, respectively), but less than S-adeanosyl methionine in patients with chronic hepatitis (WMD 106.00, 95%CI 189.05 to 22.95). There may be a dose-effect relationship in Yinzhihuang injection, higher doses had better effect (WMD 11.50, 95%CI 16.53 to 6.47). No fatal side effects were reported.
Conclusions 　It is noted that Yinzhihuang injection can abate jaundice of icteric viral hepatitis. Due to low statistical power and high risk of selection bias, performance bias and measurement bias of the included trials, these conclusions need to be treated cautiously.

Citation： CHEN Jun,CHEN Huiyang,LIU Zhichen,WU Taixiang. Effect and Safety of Yinzhihuang Injection for Icteric Viral Hepatitis: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2005, 05(6): 461-465. doi: Copy

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13.	China Medical Association. Prevention and cure of virus hepatitis[J]. Chinese Journal Intern Medicine, 2001; 40(1): 62.
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15.	State drug evaluation center. National essentional drugs (Chinese traditional patent medicine)[M]. Beijing: People Medicine Press House, 2003; 417-418.
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1. 石理兰, 张琳, 窦晓光. 病毒性肝炎的诊断[J]. 辽宁药物与临床, 2002; 7(2): 64.
2. 中华医学会传染病与寄生虫病学分会、肝病学分会. 病毒性肝炎防治方案[J]. 中华内科杂志, 2001; 40(1): 62.
3. 史天陆, 陶中原, 黄家伦. 茵栀黄注射液的临床应用与展望[J]. 基层中药志, 2000; 14(3): 58.
4. 国家药品评价中心. 国家基本药物(中成药)[M]. 北京: 人民卫生出版社, 2003; 417～418.
5. 金英爱, 李英顺. 茵栀黄注射液治疗病毒性肝炎疗效观察[J]. 中医药学报, 2002; 30(3): 19.
6. 王辉, 刘俊. 茵栀黄、苦黄、古拉定治疗急性黄疸型肝炎疗效观察[J]. 云南中医学院学报, 2004; 27(1): 31～32.
7. 倪若愚, 张佩弦, 罗端德, 阮峻峰. 茵栀黄注射液治疗急性黄疸型肝炎的临床评价[J]. 医药导报, 1994; 13(3): 106.
8. 谢仕斌, 黄桂梅, 邓云珍, 谢冬英, 陈幼明, 姚集鲁. 腺苷蛋氨酸治疗急、慢性病毒性肝炎的临床疗效[J]. 中国新药杂志, 1999; 8(12): 824～826.
9. 屠德敬, 兰朝廷, 林维进, 刘盛军. 茵栀黄注射液治疗急性黄疸型肝炎56例疗效观察[J]. 中华实用中西医杂志, 2004; 4(17): 7.
10. 崔建华, 赵春红, 吴志敏. 茵栀黄注射液治疗病毒性肝炎高胆红素血症38例疗效观察[J]. 中原医刊, 2003; 30(2): 50.
11. 陈海明, 李方学. 茵栀黄对病毒性肝炎高胆红素血症的影响[J]. 浙江中西医结合杂志, 2003; 13(3): 164.
12. Shi LL, Zhang L, Dou XG. Diagnosis of virus hepatitis[J]. Liaoning Medication and Clinic, 2002; 7(2): 64.
13. China Medical Association. Prevention and cure of virus hepatitis[J]. Chinese Journal Intern Medicine, 2001; 40(1): 62.
14. Shi TL, Tao ZY, Huang JL. Clinic applications and expectation of Yinzhihuang Injection[J]. Primary Journal of Chinese Materia Medica, 2000; 14(3): 58.
15. State drug evaluation center. National essentional drugs (Chinese traditional patent medicine)[M]. Beijing: People Medicine Press House, 2003; 417-418.
16. Jin YA, Li YS. Curative effect observation of Yinzhihuang injection for virus hepatitis[J]. Acta Chinese Medicine and Pharmacology, 2002; 30(3): 19.
17. Wang H, Liu J. Effect observation of Yinzhihuang injection for acute icteric hepatitis[J]. Journal of Yunnan College of Traditional Chinese Medicine, 2004; 27(1): 31-32.
18. Ni RY, Zhang PX, Luo DD, Ruan JF. Clinical evaluation on Yinzhihuang injection for acute icteric hepatitis[J]. Herald of Medicine, 1994; 13(3): 106.
19. Aldeson P, Green S, Higgins JPT editors. Cochrane Reviews Handbook 4.2.2[Updated December 2003] [M/CD]. In: The Cochrane Library, Ossue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
20. Xie SB, Huang GM, Deng YZ, Xie DY, Chen YM, Yao JL. Observation of S-Adeanosyl methionine therapeutic effect on acute and chronic hepatitis[J]. Chinese New Drugs Journal, 1999; 8(12): 824-826.
21. Tu DJ, Lan CT, Lin WJ, Liu SJ. Curative effect observation on treating acute icteric hepatitis in 56 cases[J]. Chinese Journal of the Practical Chinese with Modern Medicine, 2004; 4(17): 7.
22. Cui JH, Zhao CH, Wu ZM. Observation of Yinzhihuang Injection for icteric virus hepatitis in 38 cases[J]. Central Plains Medical Journal, 2003; 30(2): 50.
23. Chen HM, Li FX. Effect of Yinzhihuang injection for icteric virus hepatitis[J]. Zhejiang Journal of Chinese with Modern Medicine, 2003; 13(3): 164.

Chinese Journal of Evidence-Based Medicine

Effect and Safety of Yinzhihuang Injection for Icteric Viral Hepatitis: A Systematic Review

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