Evidence for Anaphylaxis Induced by Intramuscular Injection of Vitamin K1_Chinese Journal of Evidence-Based Medicine

Authors：

LI Zi , FU Ping , ZHOU Li , LIU Xianrong , HUANG Songmin

Department of Nephrology; West China Hospital; Sichuan University; Chengdu 610041; China;

Corresponding author：

Keywords：

Vitamin K1; Adverse effect; Hypersensitivity; Clinical evidence

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Although anaphylaxis induced by vitamin K1 seldom happens, 4 allergic cases were observed in the patients we treated recently who were given intramuscular injection of vitamin K1 before renal biopsy. To provide the best clinical evidence, we searched MEDLINE （-May 2005） and evaluated the studies. The studies were only case reports and retrospective reviews which showed the anaphylaxis were mainly allergic dermatitis with different manifestation and reaction time. The serious reactions such as allergic shock was very rare. We conclude that although vitamin K1 anaphylaxis is rare, strict indications should be followed and the drug surveillance on adverse events should be strengthened.

Citation： LI Zi,FU Ping,ZHOU Li,LIU Xianrong,HUANG Songmin. Evidence for Anaphylaxis Induced by Intramuscular Injection of Vitamin K1. Chinese Journal of Evidence-Based Medicine, 2005, 05(8): 641-643. doi: Copy

1.	Riegert-Johnson DL, Volcheck GW. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review[J]. Ann Allergy Asthma Immunol, 2002; (4): 400-406.
2.	Sommer S, Wilkinson SM, Peckham D, Wilson C. Type IV hypersensitivity to vitamin K [J]. Contact Dermatitis, 2002 ; 46(2): 94-96.
3.	Gettler SL, Fung MA. Off-center fold: indurated plaques on the arms of a 52-year-old man. Diagnosis: Cutaneous reaction to phytonadione injection [J]. Arch Dermatol, 2001; 137(7): 957-962.
4.	Wilkins K, DeKoven J, Assaad D.Cutaneous reactions associated with vitamin K1 [J]. J Cutan Med Surg, 2000; 4(3): 164-168.
5.	Wong DA, Freeman S. Cutaneous allergic reaction to intramuscular vitamin K1 [J]. Australas J Dermatol, 1999; 40(3): 147-152.
6.	Balato N, Cuccurullo FM, Patruno C, Ayala F. Adverse skin reactions to vitamin K1: report of 2 cases [J]. Contact Dermatitis, 1998; 38(6): 341-342.
7.	Moreau-Cabarrot A, Giordano-Labadie F, Bazex J. Cutaneous hypersensitivity at the site of injection of vitamin K1 [J]. Ann Dermatol Venereol, 1996; 123(3): 177-179.
8.	Bruynzeel I, Hebeda CL, Folkers E, Bruynzeel DP.Cutaneous hypersensitivity reactions to vitamin K: 2 case reports and a review of the literature [J]. Contact Dermatitis, 1995; 32(2): 78-82.
9.	Guidetti MS, Vincenzi C, Papi M, Tosti A.Sclerodermatous skin reaction after vitamin K1 injections[J]. Contact Dermatitis, 1994; 31(1): 45-46.
10.	Lemlich G, Green M, Phelps R, Lebwohl M, Don P, Gordon M.Cutaneous reactions to vitamin K1 injections [J]. J Am Acad Dermatol, 1993; 28(2 Pt 2): 345-347.
11.	Tuppal R, Tremaine R. Cutaneous eruption from vitamin K1 injection [J]. J Am Acad Dermatol, 1992; 27(1): 105-106.
12.	Martinez-Abad M, Delgado F, Palop V, Morales-Olivas FJ. Vitamin K1 and anaphylactic shock[J]. DICP, 1991; 25(7-8): 871-872.
13.	Allue Bellosta L, Iniguez Navarro D, Peyri Rey J.A localized skin reaction caused by intramuscular vitamin K1 [J]. Rev Clin Esp, 1989; 185(4): 217-218.
14.	de la Rubia J, Grau E, Montserrat I, Zuazu I, Paya A. Anaphylactic shock and vitamin K1 [J]. Ann Intern Med, 1989; 110(11): 943.
15.	Anderson TH, Hindsholm KB, Fallingborg J. Severe complication to phytomenadione after intramuscular injection in woman in labor. Case report and review of literature [J]. Acta Obstet Gynecol Scand, 1989; 68(4): 381-382.
16.	Finkelstein H, Champion MC, Adam JE. Cutaneous hypersensitivity to vitamin K1 injection[J]. J Am Acad Dermatol, 1987; 16(3 Pt 1): 540-545.
17.	Havel M, Muller M, Graninger W, Kurz R, Lindemayr H. Tolerability of a new vitamin K1 preparation for parenteral administration to adults: one case of anaphylactoid reaction [J]. Clin Ther, 1987; 9(4): 373-379.
18.	Janin-Mercier A, Mosser C, Souteyrand P, Bourges M.Subcutaneous sclerosis with fasciitis and eosinophilia after phytonadione injections [J]. Arch Dermatol, 1985; 121(11): 1421-1423.
19.	Robison JW, Odom RB. Delayed cutaneous reaction to phytonadione[J]. Arch Dermatol, 1978; 114(12): 1790-1792.
20.	Fiore LD, Scola MA, Cantillon CE, Brophy MT. Anaphylactoid reactions to vitamin K [J]. J Thromb Thrombolysis, 2001; 11(2): 175-183.

1. Riegert-Johnson DL, Volcheck GW. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review[J]. Ann Allergy Asthma Immunol, 2002; (4): 400-406.
2. Sommer S, Wilkinson SM, Peckham D, Wilson C. Type IV hypersensitivity to vitamin K [J]. Contact Dermatitis, 2002 ; 46(2): 94-96.
3. Gettler SL, Fung MA. Off-center fold: indurated plaques on the arms of a 52-year-old man. Diagnosis: Cutaneous reaction to phytonadione injection [J]. Arch Dermatol, 2001; 137(7): 957-962.
4. Wilkins K, DeKoven J, Assaad D.Cutaneous reactions associated with vitamin K1 [J]. J Cutan Med Surg, 2000; 4(3): 164-168.
5. Wong DA, Freeman S. Cutaneous allergic reaction to intramuscular vitamin K1 [J]. Australas J Dermatol, 1999; 40(3): 147-152.
6. Balato N, Cuccurullo FM, Patruno C, Ayala F. Adverse skin reactions to vitamin K1: report of 2 cases [J]. Contact Dermatitis, 1998; 38(6): 341-342.
7. Moreau-Cabarrot A, Giordano-Labadie F, Bazex J. Cutaneous hypersensitivity at the site of injection of vitamin K1 [J]. Ann Dermatol Venereol, 1996; 123(3): 177-179.
8. Bruynzeel I, Hebeda CL, Folkers E, Bruynzeel DP.Cutaneous hypersensitivity reactions to vitamin K: 2 case reports and a review of the literature [J]. Contact Dermatitis, 1995; 32(2): 78-82.
9. Guidetti MS, Vincenzi C, Papi M, Tosti A.Sclerodermatous skin reaction after vitamin K1 injections[J]. Contact Dermatitis, 1994; 31(1): 45-46.
10. Lemlich G, Green M, Phelps R, Lebwohl M, Don P, Gordon M.Cutaneous reactions to vitamin K1 injections [J]. J Am Acad Dermatol, 1993; 28(2 Pt 2): 345-347.
11. Tuppal R, Tremaine R. Cutaneous eruption from vitamin K1 injection [J]. J Am Acad Dermatol, 1992; 27(1): 105-106.
12. Martinez-Abad M, Delgado F, Palop V, Morales-Olivas FJ. Vitamin K1 and anaphylactic shock[J]. DICP, 1991; 25(7-8): 871-872.
13. Allue Bellosta L, Iniguez Navarro D, Peyri Rey J.A localized skin reaction caused by intramuscular vitamin K1 [J]. Rev Clin Esp, 1989; 185(4): 217-218.
14. de la Rubia J, Grau E, Montserrat I, Zuazu I, Paya A. Anaphylactic shock and vitamin K1 [J]. Ann Intern Med, 1989; 110(11): 943.
15. Anderson TH, Hindsholm KB, Fallingborg J. Severe complication to phytomenadione after intramuscular injection in woman in labor. Case report and review of literature [J]. Acta Obstet Gynecol Scand, 1989; 68(4): 381-382.
16. Finkelstein H, Champion MC, Adam JE. Cutaneous hypersensitivity to vitamin K1 injection[J]. J Am Acad Dermatol, 1987; 16(3 Pt 1): 540-545.
17. Havel M, Muller M, Graninger W, Kurz R, Lindemayr H. Tolerability of a new vitamin K1 preparation for parenteral administration to adults: one case of anaphylactoid reaction [J]. Clin Ther, 1987; 9(4): 373-379.
18. Janin-Mercier A, Mosser C, Souteyrand P, Bourges M.Subcutaneous sclerosis with fasciitis and eosinophilia after phytonadione injections [J]. Arch Dermatol, 1985; 121(11): 1421-1423.
19. Robison JW, Odom RB. Delayed cutaneous reaction to phytonadione[J]. Arch Dermatol, 1978; 114(12): 1790-1792.
20. Fiore LD, Scola MA, Cantillon CE, Brophy MT. Anaphylactoid reactions to vitamin K [J]. J Thromb Thrombolysis, 2001; 11(2): 175-183.

Chinese Journal of Evidence-Based Medicine

Evidence for Anaphylaxis Induced by Intramuscular Injection of Vitamin K1

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