Analysis of Adverse Drug Reaction in 680 Patients with SARS in Xiao Tang Shan Hospital_Chinese Journal of Evidence-Based Medicine

Authors：

ZHOU Xiaoqing ¹ , WANG Rui ¹ , DONG Jun ¹ , WEI Rong ² , ZHOU Jian ¹ , ZHOU Yachun ² , WANG Jiesong ² , CHEN Kun ¹ , LIANG Beibei ¹ , CAO Xiutang ¹ , GUO Daihong ¹ , WANG Jin ¹ , XU Yanping ¹ , ZHU Xiumei ² , XU Hongmin ¹ , ZHOU Zhe ² , LIU Jianfeng ² , LI Youping ³ , XIONG Ying ³ , SUN Xin ³

1.Chinese PLA General Hospital; Beijing 100853; China2.Xiao Tang Shan Hospital; Beijing 100000; China3.Chinese Evidence-Based Medicine Center; West China Hospital; Sichuan University; Chengdu 610041;

Corresponding author：

Keywords：

Severe acute respiratory syndrome; Adverse drug reactions

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Objective 　To investigate the adverse drug reactions (ADRs) of patients with SARS in Xiao Tang Shan Hospital.
Methods 　We developed and distributed Drug Use Handbook and established ADRs monitoring group to guide resaonable drug use. We followed up the process and collected clinical report on ADRs. We retrospectively analyzed the data on ADRs by the classification and grade of ADRs according to WHO and Hospital Information Sysytem (HIS) of Chinese PLA General Hospital.
Results 　We collected 193 (87 males and 106 females) patients with ADRs among 680 SARS patients with incidence rate of ADRs of 28.38%. The ADRs incidence rate was higher in females and elders. Critical SARS patients and SARS patients with diabetes were more susceptible to ADRs. Large dosage and combination of drugs may induce ADRs. Steroids may be a main cause of ADRs. The ADRs incidence rate induced by injection was higher than that induced by all kinds of oral drugs. ADRs mainly happened in hematological, endocrine and digestive systems.
Conclusion 　SARS patients are prescribed many kinds of medications. Large dosage of so many medications may lend to high incidence rate of ADRs. Steroid should be cautiously used in the treatment of SARS.

Citation： ZHOU Xiaoqing,WANG Rui,DONG Jun,WEI Rong,ZHOU Jian,ZHOU Yachun,WANG Jiesong,CHEN Kun,LIANG Beibei,CAO Xiutang,GUO Daihong,WANG Jin,XU Yanping,ZHU Xiumei,XU Hongmin,ZHOU Zhe,LIU Jianfeng,LI Youping,XIONG Ying,SUN Xin. Analysis of Adverse Drug Reaction in 680 Patients with SARS in Xiao Tang Shan Hospital. Chinese Journal of Evidence-Based Medicine, 2004, 04(10): 700-706. doi: Copy

1.	［1］Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ; SARS Working Group. A novel coronavirus associated with severe acute respiratory syndrome[J]. N Engl J Med,2003;348(20):1 953-1 966.
2.	［2］Update: Outbreak of severe acute respiratory syndrome-worldwide, 2003[J]. MMWR Morb Mortal Wkly Rep, 2003; 52(12): 241-246, 248.
3.	［3］Diagnosis standard of SARS. 2003传染性非典型肺炎诊断标准(试行). 2003.
4.	［4］Interpretation of ADRs supervise software edited by WHO WHO.
5.	国际药品不良反应监察计算机软件说明.
6.	［5］Liu ZY, Li TS, Wang Z, Xu ZJ, Wang HL, Yu Y, Du TK, Bai Y, Qiu ZF, Lv W, Fan HW, Ma XJ, Zhou, BT, Wang AX, Cai BQ, Deng GH, Ni AP. Clinical features and therapy of 106 cases of severe acute respiratory syndrome[J]. Chin J Intern Med, 2003; 42(6): 373-377.
7.	刘正印, 李太生, 王仲, 徐作军, 王焕玲, 于莺, 杜铁宽, 白彦, 邱志峰, 吕玮, 范洪伟, 马小军, 周宝桐, 王爱霞, 蔡柏蔷, 邓国华, 倪安平. 106例重症急性呼吸综合征患者的临床特征与治疗总结[J]. 中华内科杂志, 2003; 42(6): 373～377.
8.	［6］Wang R, Zhou XQ, Dong J, Cao X T, Zhou YC, Wang J, Guo DH, Chen K, Zhou J, Wang JS, Zhu XM, Liang BB, Xu YP, Z hou XZ, LI YP, Sun X, Xiong Y. Utilization analysis of drug efficacy of the 680 cases SARS of patients in Xiao Tang Shan hospital of PLA[J]. Chinese J Evidence-Based Medicine, 2004; 4(7): 474-481.
9.	王睿, 周筱青, 董军, 魏荣, 曹秀堂, 周亚春, 王瑾, 郭代红, 陈騉, 周践, 王洁松, 朱秀美, 梁蓓蓓, 徐艳萍, 周先志, 李幼平, 孙鑫, 熊鹰. 小汤山680例SARS患者药物利用分析[J]. 中国循证医学杂志, 2004; 4(7): 474～481.
10.	［7］Chen XQ, editor-in-chief. New pharmacology[M]. 15th ed. Beijing: People sanitation publishing company. 2003. p.564.
11.	陈新谦, 主编. 新编药物学[M]. 第15版. 北京:人民卫生出版社. 2003. p.564.
12.	［8］Song YJ, Shi LY. Analyze of interaction of common drugs[J]. Journal of Xizang Medicine, 1999; 20(4): 42-43.
13.	宋荣杰, 史连英. 常见的药物相互作用实例浅析[J]. 西藏医药杂志, 1999; 20(4): 42～43.
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15.	马晓岚, 陈可冀院士:中西医联手阻击SARS[EB/OL]. http://www.cas.ac.cn/html/Dir/2003/05/21/3669.htm, 2003-05-21.

1. ［1］Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ; SARS Working Group. A novel coronavirus associated with severe acute respiratory syndrome[J]. N Engl J Med,2003;348(20):1 953-1 966.
2. ［2］Update: Outbreak of severe acute respiratory syndrome-worldwide, 2003[J]. MMWR Morb Mortal Wkly Rep, 2003; 52(12): 241-246, 248.
3. ［3］Diagnosis standard of SARS. 2003传染性非典型肺炎诊断标准(试行). 2003.
4. ［4］Interpretation of ADRs supervise software edited by WHO WHO.
5. 国际药品不良反应监察计算机软件说明.
6. ［5］Liu ZY, Li TS, Wang Z, Xu ZJ, Wang HL, Yu Y, Du TK, Bai Y, Qiu ZF, Lv W, Fan HW, Ma XJ, Zhou, BT, Wang AX, Cai BQ, Deng GH, Ni AP. Clinical features and therapy of 106 cases of severe acute respiratory syndrome[J]. Chin J Intern Med, 2003; 42(6): 373-377.
7. 刘正印, 李太生, 王仲, 徐作军, 王焕玲, 于莺, 杜铁宽, 白彦, 邱志峰, 吕玮, 范洪伟, 马小军, 周宝桐, 王爱霞, 蔡柏蔷, 邓国华, 倪安平. 106例重症急性呼吸综合征患者的临床特征与治疗总结[J]. 中华内科杂志, 2003; 42(6): 373～377.
8. ［6］Wang R, Zhou XQ, Dong J, Cao X T, Zhou YC, Wang J, Guo DH, Chen K, Zhou J, Wang JS, Zhu XM, Liang BB, Xu YP, Z hou XZ, LI YP, Sun X, Xiong Y. Utilization analysis of drug efficacy of the 680 cases SARS of patients in Xiao Tang Shan hospital of PLA[J]. Chinese J Evidence-Based Medicine, 2004; 4(7): 474-481.
9. 王睿, 周筱青, 董军, 魏荣, 曹秀堂, 周亚春, 王瑾, 郭代红, 陈騉, 周践, 王洁松, 朱秀美, 梁蓓蓓, 徐艳萍, 周先志, 李幼平, 孙鑫, 熊鹰. 小汤山680例SARS患者药物利用分析[J]. 中国循证医学杂志, 2004; 4(7): 474～481.
10. ［7］Chen XQ, editor-in-chief. New pharmacology[M]. 15th ed. Beijing: People sanitation publishing company. 2003. p.564.
11. 陈新谦, 主编. 新编药物学[M]. 第15版. 北京:人民卫生出版社. 2003. p.564.
12. ［8］Song YJ, Shi LY. Analyze of interaction of common drugs[J]. Journal of Xizang Medicine, 1999; 20(4): 42-43.
13. 宋荣杰, 史连英. 常见的药物相互作用实例浅析[J]. 西藏医药杂志, 1999; 20(4): 42～43.
14. ［9］Ma XL, Chen KJ academician: Integrated traditional Chinese medicine with western medicine for SARS[EB/OL]. http://www.cas.ac.cn/html/Dir/2003/05/21/3669.htm, 2003-05-21.
15. 马晓岚, 陈可冀院士:中西医联手阻击SARS[EB/OL]. http://www.cas.ac.cn/html/Dir/2003/05/21/3669.htm, 2003-05-21.

Chinese Journal of Evidence-Based Medicine

Analysis of Adverse Drug Reaction in 680 Patients with SARS in Xiao Tang Shan Hospital

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