A Meta-analysis of Parkin Gene S/N167 Polymorphism in the Risks of Parkinson’s Disease_Chinese Journal of Evidence-Based Medicine

Authors：

ZOU Haiqiang ¹ , CHEN Biao ¹ , PENG Xiaoxia ² , FENG Xiuli ¹ , DONG Xiumin ¹

1. Department of Neurology; Beijing Geriatrics Institute; Xuanwu Hospital of Capital University of Medical Sciences; Beijing 100053; China2. Public Health Statistics Center; Department of Epidemiology; Capital University of Medical Sciences; Beijing 100053; China;

Corresponding author：

Keywords：

Parkinson’s disease; Parkin gene; S/N167; Polymorphism; Meta-analysis

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To investigate the association between parkin gene S/N167 polymorphism and the risk for Parkinson’s Disease (PD) using the methods of meta-analysis.
Method 　References were retrieved through the computerized Medline, Cochrane Library and CBM search from 1998 to 2003. Similar search strategies were applied to each of these databases. The unpublished data of our study were also included.Studies eligible for this meta-analysis should meet the following inclusion criterias: ① presentation of original data and a cross-sectional design. ② PD as the outcome of interest. ③ an odds ratio (or enough information to calculate it) reported to quantify the association between the frequencies of genotypes and alleles of parkin gene S/N167 polymorphism and the risk for PD. All analyses were conducted with ’Review Manager’ Version 4.2 software.
Results 　A total of 1 239 PD patients and 1 168 control studies were studied. The combined data statistics revealed the frequencies of the genotypes and alleles were higher, but showed no statistically difference, for the total PD group from that ofthe control group (Z=1.57, P=0.12). After stratification according to eastern or western origin, the frequencies of G/A+A/A genotype and a allele of eastern origin were significantly higher [test for overall effect: P=0.01, OR=1.41, 95%CI= (1.08 to1.83); P=0.01, OR=1.25, 95%CI= (1.08 to1.44), respectively] in the PD group than that in the control group. After including our unpublished data, the results remained constant, and the trend was much more pronounced. Conversely, there was no difference [test for overall effect: P=0.08, OR=0.55, 95%CI= (0.30 to1.02); P=0.08, OR=0.55, 95%CI= (0.28 to1.08)] in the frequencies of allele and genotype of western origin between the PD patients and the controls.
Conclusions 　The meta-analysis suggests that the parkin gene S/N167 polymorphism might be a genetic risk factor for PD of eastern origin, but not a definite risk for PD of western origin.

Citation： ZOU Haiqiang,CHEN Biao,PENG Xiaoxia,FENG Xiuli,DONG Xiumin. A Meta-analysis of Parkin Gene S/N167 Polymorphism in the Risks of Parkinson’s Disease. Chinese Journal of Evidence-Based Medicine, 2004, 04(3): 157-163. doi: Copy

1.	［1］Chan P, Tanner CM, Zhao L, et al. Prevalence of Parkinson ’s disease in Beijing, China[J]. Neurology, 2000; 54 (Suppl 3): A348.
2.	［2］Dekker MC, Bonifati V, van Duijn CM. Parkinson’s disease:piecing together a genetic jigsaw [ J ]. Brain, 2003; 126 ( Pt 8) :1 722-1 733.
3.	［3］Lim KL, Dawson VL, Dawson TM. The genetics of Parkinson’s disease [ J ]. Curr Neurol Neurosci Rep, 2002; 2 ( 5 ):439-446.
4.	［4］Scott WK, Nance MA, Watts RL, Hubble Jp, Koller WC,Lyons K, Pahwa R, Stem MB, Colcher A, Hiner BC,Jankovic J, Ondo WG, Allen FH Jr, Goetz CG, Small GW,Masterman D, Mastaglia F, Laing NG, Stajich JM,Slotterbeck B, Booze MW, Ribble RC, Rampersaud E,West SG, Gibson RA, Middleton LT, Roses AD, Haines JL, Scott BL, Vance JM, Pericak-Vance MA. Complete genomic screen in Parkinson disease: evidence for multiple genes[J]. JAMA, 2001; 286(18) :2 239-2 244.
5.	［5］Lucking CB, Durr A, Bonifati V, Vaughan J, De Michele G,Gasser T, Harhangi BS, Meco G, Denefle P, Wood NW,Agid Y, Brice A. Association between early-onset Parkinsons disease and mutations in the parkin gene[J]. N Engl J Med,2000; 342(21) :1 560-1 567.
6.	［6］Oliveira SA, Scott WK, Martin ER, Nance MA, Watts RL,Hubble Jp, Koller WC, Pahwa R, Stem MB, Hiner BC,Ondo WG, Allen FH Jr, Scott BL, Goetz CG, Small GW,Mastaglia F, Stajich JM, Zhang F, Booze MW, Winn MP,Middleton LT, Haines JL, Pericak-Vance MA, Vance JM.Parkin mutatons and susceptibility alleles in late-onset Parkinson’s disease[J]. Ann Neurol, 2003; 53(5) :624-629.
7.	［7］Hattoti N, Kitada T, Matsumine H, Asakawa S, Yamamura Y, Yoshino H, Kobayashi T, Yokochi M, Wang M,Yoritaka A, Kondo T, Kuzuhara S, Nakamura S, Shimizu N, Mizuno Y. Molecular genetic analysis of a novel parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: evidence for variable homozygous deletions in the parkin gene in affected individuals [J ]. Ann Neurol, 1998;44(6) :935-941.
8.	［8］Klein C, Schumacher K, Jacob H, Hagenah J, Kis B, Garrels J, Schwinger E, Ozelius L, Pramstaller P, Vieregge P,Kramer PL. Association Studies of Parkinson’s Disease and parkin Polymorphisms [ J ]. Annals of Neurology, 2000; 48( 1 ): 126-127.
9.	［9］Satoh JI, Kuroda Y. Association of codon 167 Ser/Asn heterozygosity in the parkin gene with sporadic Parkinson’s disease[J].Neuroreport, 1999; 10(13): 2 735-2 739.
10.	［10］Hu CJ, Sung SM, Liu HC, Lee CC, Tsai CH, ChangJG.Polymorphisms of the Parkin Gene in Sporadic Parkinson’s Disease among Chinese in Taiwan[J]. European Neurology,2000; 44(2): 90-93.
11.	［11］Wang M, Hattori N, Matsumine H, Kobayashi T, Yoshino H, Morioka A, Kitada T, Asakawa S, Minoshima S, Shimizu N, Mizuno Y. Polymorphism in the Parkin Gene in Sporadic Parkinson’s Disease[J]. Annals of Neurology, 1999; 45(5):655-658.
12.	［12］PengR, Yinru G, Yuan Q, Li T, Latsoudis H, Yuan G,Luo D, Liu X, Collier DA. Mutation screening and association analysis of the parkin gene in parkinson’s disease patients from south-west China [ J ]. European Neurology,2003; 49(2) :85-89.
13.	［13］Mata IF , Alvarez V , Garcia- Moreira V , Guisasola LM ,Ribacoba R, Salvador C, Blazquez M, Sarmiento RG, Lahoz CH, Menes BB, Garcia EC. Single-nucleotide polymorphisms in the promoter region of the PARKIN gene and Parkinson’s disease[J]. Neurosci Lett, 2002,329(2):149-152.
14.	［14］NingYP, Liu ZL, Xu YM, et al. Association study ofparkin gene S/N 167 ploy-morphism with sporadic Parkinson’s disease[J]. Chin J Med Genet. 2001; 19(6): 513-514.
15.	宁玉萍,刘焯霖,徐严明等.parkin基因S/N167多态性与散发性帕金森病关联研究[J].中华医学遗传学杂志,2002;19(6):513-514.
16.	［15］Mellick GD, BuchananDD, HattoriN, Brookes AJ, Mizuno Y, Le Couteur DG, Silbum PA. The parkin gene S/N167polymorphism in Australian Parkinson’s disease patients and controls[J]. Parkinsonism and Related Disorders, 2001; 7(2) :89-91.
17.	［16］Oliveira SA, Scott WK, Nance MA, Watts Ri, Hubble Jp,Koller WC, Lyons KE, Pahwa R, Stem MB, Hiner BC,Jankovic J, Ondo WG, Allen FH Jr, Scott BL, Goetz CG,Small GW, Mastaglia FL, Stajich JM, Zhang F, Booze MW,Reaves JA, Middleton LT, Haines JL, Pericak-Vance MA,Vance JM, Martin ER. Association study of parkin gene polymorphisms with idiopathic Parkinson disease [ J ]. Arch Neurol, 2003 ;60(7 ) :975-980.
18.	［17］Abbas N, Lucking CB, Ricard S, Durr A, Boulfati V, De Michele G, Bouley S, Vaughan JR, Gasser T, Marconi R,Broussolle E, Brefel-Courbon C, Hathangi BS, Oostra BA,Fabrizio E, Bohme GA, Pradier L, Wood NW, Filla A,Meco G, Denefle P, Agid Y, Brice A. A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe[J]. Hum Mol Genet, 1999;8(4) :567-574.
19.	［18］Petitti DB. Meta-analysis, decision analysis and cost-effectiveness[M]. New York :Oxford University Press, 1994; 1-237.

1. ［1］Chan P, Tanner CM, Zhao L, et al. Prevalence of Parkinson ’s disease in Beijing, China[J]. Neurology, 2000; 54 (Suppl 3): A348.
2. ［2］Dekker MC, Bonifati V, van Duijn CM. Parkinson’s disease:piecing together a genetic jigsaw [ J ]. Brain, 2003; 126 ( Pt 8) :1 722-1 733.
3. ［3］Lim KL, Dawson VL, Dawson TM. The genetics of Parkinson’s disease [ J ]. Curr Neurol Neurosci Rep, 2002; 2 ( 5 ):439-446.
4. ［4］Scott WK, Nance MA, Watts RL, Hubble Jp, Koller WC,Lyons K, Pahwa R, Stem MB, Colcher A, Hiner BC,Jankovic J, Ondo WG, Allen FH Jr, Goetz CG, Small GW,Masterman D, Mastaglia F, Laing NG, Stajich JM,Slotterbeck B, Booze MW, Ribble RC, Rampersaud E,West SG, Gibson RA, Middleton LT, Roses AD, Haines JL, Scott BL, Vance JM, Pericak-Vance MA. Complete genomic screen in Parkinson disease: evidence for multiple genes[J]. JAMA, 2001; 286(18) :2 239-2 244.
5. ［5］Lucking CB, Durr A, Bonifati V, Vaughan J, De Michele G,Gasser T, Harhangi BS, Meco G, Denefle P, Wood NW,Agid Y, Brice A. Association between early-onset Parkinsons disease and mutations in the parkin gene[J]. N Engl J Med,2000; 342(21) :1 560-1 567.
6. ［6］Oliveira SA, Scott WK, Martin ER, Nance MA, Watts RL,Hubble Jp, Koller WC, Pahwa R, Stem MB, Hiner BC,Ondo WG, Allen FH Jr, Scott BL, Goetz CG, Small GW,Mastaglia F, Stajich JM, Zhang F, Booze MW, Winn MP,Middleton LT, Haines JL, Pericak-Vance MA, Vance JM.Parkin mutatons and susceptibility alleles in late-onset Parkinson’s disease[J]. Ann Neurol, 2003; 53(5) :624-629.
7. ［7］Hattoti N, Kitada T, Matsumine H, Asakawa S, Yamamura Y, Yoshino H, Kobayashi T, Yokochi M, Wang M,Yoritaka A, Kondo T, Kuzuhara S, Nakamura S, Shimizu N, Mizuno Y. Molecular genetic analysis of a novel parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: evidence for variable homozygous deletions in the parkin gene in affected individuals [J ]. Ann Neurol, 1998;44(6) :935-941.
8. ［8］Klein C, Schumacher K, Jacob H, Hagenah J, Kis B, Garrels J, Schwinger E, Ozelius L, Pramstaller P, Vieregge P,Kramer PL. Association Studies of Parkinson’s Disease and parkin Polymorphisms [ J ]. Annals of Neurology, 2000; 48( 1 ): 126-127.
9. ［9］Satoh JI, Kuroda Y. Association of codon 167 Ser/Asn heterozygosity in the parkin gene with sporadic Parkinson’s disease[J].Neuroreport, 1999; 10(13): 2 735-2 739.
10. ［10］Hu CJ, Sung SM, Liu HC, Lee CC, Tsai CH, ChangJG.Polymorphisms of the Parkin Gene in Sporadic Parkinson’s Disease among Chinese in Taiwan[J]. European Neurology,2000; 44(2): 90-93.
11. ［11］Wang M, Hattori N, Matsumine H, Kobayashi T, Yoshino H, Morioka A, Kitada T, Asakawa S, Minoshima S, Shimizu N, Mizuno Y. Polymorphism in the Parkin Gene in Sporadic Parkinson’s Disease[J]. Annals of Neurology, 1999; 45(5):655-658.
12. ［12］PengR, Yinru G, Yuan Q, Li T, Latsoudis H, Yuan G,Luo D, Liu X, Collier DA. Mutation screening and association analysis of the parkin gene in parkinson’s disease patients from south-west China [ J ]. European Neurology,2003; 49(2) :85-89.
13. ［13］Mata IF , Alvarez V , Garcia- Moreira V , Guisasola LM ,Ribacoba R, Salvador C, Blazquez M, Sarmiento RG, Lahoz CH, Menes BB, Garcia EC. Single-nucleotide polymorphisms in the promoter region of the PARKIN gene and Parkinson’s disease[J]. Neurosci Lett, 2002,329(2):149-152.
14. ［14］NingYP, Liu ZL, Xu YM, et al. Association study ofparkin gene S/N 167 ploy-morphism with sporadic Parkinson’s disease[J]. Chin J Med Genet. 2001; 19(6): 513-514.
15. 宁玉萍,刘焯霖,徐严明等.parkin基因S/N167多态性与散发性帕金森病关联研究[J].中华医学遗传学杂志,2002;19(6):513-514.
16. ［15］Mellick GD, BuchananDD, HattoriN, Brookes AJ, Mizuno Y, Le Couteur DG, Silbum PA. The parkin gene S/N167polymorphism in Australian Parkinson’s disease patients and controls[J]. Parkinsonism and Related Disorders, 2001; 7(2) :89-91.
17. ［16］Oliveira SA, Scott WK, Nance MA, Watts Ri, Hubble Jp,Koller WC, Lyons KE, Pahwa R, Stem MB, Hiner BC,Jankovic J, Ondo WG, Allen FH Jr, Scott BL, Goetz CG,Small GW, Mastaglia FL, Stajich JM, Zhang F, Booze MW,Reaves JA, Middleton LT, Haines JL, Pericak-Vance MA,Vance JM, Martin ER. Association study of parkin gene polymorphisms with idiopathic Parkinson disease [ J ]. Arch Neurol, 2003 ;60(7 ) :975-980.
18. ［17］Abbas N, Lucking CB, Ricard S, Durr A, Boulfati V, De Michele G, Bouley S, Vaughan JR, Gasser T, Marconi R,Broussolle E, Brefel-Courbon C, Hathangi BS, Oostra BA,Fabrizio E, Bohme GA, Pradier L, Wood NW, Filla A,Meco G, Denefle P, Agid Y, Brice A. A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe[J]. Hum Mol Genet, 1999;8(4) :567-574.
19. ［18］Petitti DB. Meta-analysis, decision analysis and cost-effectiveness[M]. New York :Oxford University Press, 1994; 1-237.

Chinese Journal of Evidence-Based Medicine

A Meta-analysis of Parkin Gene S/N167 Polymorphism in the Risks of Parkinson’s Disease

Abstract Full text Figures/Tables Video References Cited by

Format

Content