Chinese Medicinal Herbs for Tubal Subfertility: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

HE Haojie ¹ , LI Shangwei ¹ , XU Liangzhi ¹ , CHEN Yao ²

1. West China Second University Hospital of Sichuan University; Chengdu 610041; China2. West China Hospital of Sichuan University; Chengdu 610041; China;

Corresponding author：

Keywords：

Chinese medicinal herbs treatment; Tubal subfertility; Randomized controlled trials; Systematic review

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Objective 　To assess the effectiveness and safety of traditional Chinese medicinal herbs for subfertility.
Method 　Databases used including MEDLINE, EMBASE, CBM and the Cochrane Controlled Trial Register (CCTR). Potentially related trials in reference lists of studies were hand searched. Published RCTs in any languages and length whether they were blind or unblind, were included. Treatments were Chinese medicinal herbs (single or compound), and controls were placebo, standard medical intervention, or no intervention. Data were extracted independently by two reviewers and analyzed with Revman 4.2 softeware.
Results 　7 randomized trials, including 1 042 patients met inclusion criteria. Methodological quality of all trials was poor. Chinese medicinal herbs were effective compared with routine antibiotics [RR 1.49, 95％CI (1.37 to1.62), P lt;0.000 01] and resulted in higher pregnancy rate [RR 1.46, 95%CI (1.09 to,1.96), P=0.01]. There were no adverse events reported in treatment group.
Conclusions 　Some Chinese medicinal herbs may be effective for subfertility. However, the evidence is too weak to draw a conclusion. More strictly designed, randomized, double-blind, placebo-controlled trials are required.

Citation： HE Haojie,LI Shangwei,XU Liangzhi,CHEN Yao. Chinese Medicinal Herbs for Tubal Subfertility: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2004, 04(4): 244-248. doi: Copy

1.	［1］Gao DL, Chen XF. Investigation of primary pregnancy rate and subfertility rate about 60 000 newly married women [ J ].Chin J 0bstet Gyneco , 1989 ;24(4) :234-235.
2.	高道利,陈霞飞六万新婚妇女初孕率和不孕率调查[J].中华妇产科杂志,1989;24(4):234～235.
3.	［2］Neville F. Hacker, J. George Moore. Essentials of obstetrics and gonaecology. See: David R. Meldrum: Infertility[M]. 3rd Ed.Philadelphia: W.B. Saunders Company,1998. 610-611.
4.	［3］Tang GL. Clinical analysis of tubal subfertility treated with Chinese traditional medicine[J]. Beijing J TCM, 2001 ;20(2) :36 ～37.
5.	唐桂兰.中药综合治疗输卵管炎性不孕症35例临床观察[J]北京中医,2001;20(2):36～37.
6.	［4］Wang TG, Feng DJ. Chinese traditional medicine for subfertility due to fallopian tube obstruction compared with western medicine (128cases) [J]. Hebei J TCM, 1995;17(4) :16-17.
7.	王廷国,冯冬菊中医辨证与西医对照治疗输卵管阻塞性不孕128例小结[J]河北中医,1995;17(4):16～17.
8.	［5］Lin J, Li KX, Zhang Y. Clinical analysis of Subfertility (58cases) due to fallopian tube obstruction treated with TCM[J].New Journal of Traditional Chinese Medicine, 1999; 31 ( 3 ):42-43.
9.	林洁,李克湘,张烨中药内外合治输卵管炎性不孕56例临床分析[J]新中医,1999;31(3):42～43.
10.	［6］Wang BP. Subfertility (300 cases) due to fallopian tube obstruction treated with Tong-Xiao-San [ J ]. Shandong J TCM, 1999 ;21 (2) :74-75.
11.	王本鹏.通消散冲剂治疗输卵管阻塞性不孕症300例[J].山东中医杂志,2002;21(2):74～75.
12.	［7］Kang JL, Xia W. Clinical study of fallopian tube obstruction treated with integrated traditional and western medicine [J ].Chinese Journal of Integrated Traditional and Western medicine,2001 ;21(6): 416-418.
13.	康佳丽,夏葳中西医结合治疗输卵管阻塞的临床研究[J].中国中西医结合杂志,2001;21(6):416～418.
14.	［8］Chen X. Sterility (68 cases) due to fallopian tube obstruction treated with TCM and Western medicine [J ]. Heilongjiang J TCM, 1997;20(4) :19.
15.	陈翔中西医结合治疗输卵管阻塞性不孕68例[J]黑龙江中医药,1997;20(4):19.
16.	［9］Liu YY. Analysis of effect on 102 infertile cases of nonspecific inflammation and oviduct obstruction with integrated traditional Chinese and western medicine [ J ]. Modern Journal of Integrated Traditional and Western Medicine , 2001; 10 ( 9 ):796-797.
17.	刘贻玉.中西医结合治疗非特异性炎症输卵管阻塞性不孕102例疗效分析[J]现代中西医结合杂志,2001;10(9):796～797.
18.	［10］Sui P. Subfertility (47 cases) due to chronic pelvic inflammation treated with TCM and Western medicine[J]. Liaoning J of TCM, 2001 ;20(5) :300.
19.	隋蓬.中西医结合治疗慢性盆腔炎性不孕47例[J].辽宁中医杂志,2001;20(5):300.
20.	［11］Peng SF, Li SF, Cai PJ. Blood-activating and Heat-clearing as a Main Therapy for Tubal Infertility[J]. Shanghai Journal of Traditional Chinese Medicine, 2000 ;34 ( 9 ) :23-25.
21.	彭少芳,李少芬,蔡佩君.活血清热法为主治疗输卵管阻塞性不孕症[J]上海中医药杂志,2000;34(9):23～25.
22.	［12］Liang Y. Medicine combined with acupuncture as the therapy for tubal subfertility[J]. Liaoning J of TCM, 2001 ;28(5) :294.
23.	梁燕针药并举治疗输卵管阻塞性不孕36例[J].辽宁中医杂志,2001;28(5):294.
24.	［13］Li M, Wu T. Clinical analysis of integrated traditional and western medicine for tubal inflammatory subfertility [ J ]. Chinese Journal of Information and Traditional Medicine, 2001 ;8 (2):57-58.
25.	李梅,吴霆.中西药内外合治输卵管炎性不孕临床分析[J].中国中医药信息杂志,2001;8(2):57～58.
26.	［14］Tu GC, Zhou Y. Report of injection in acupuncture point for fallopian obstruction (130 cases)[J]. Journal of Guiyang College of Traditional Chinese Medicine, 1997; 19 ( 4 ): 37-38.
27.	屠国春,周艳.穴位注射治疗输卵管阻塞130例报告[J].贵阳中医学院学报,1997;19(4):37～38.
28.	［15］Chen WY, Qin Y. Integrated traditional and western medicine for tubal subfertility [J ]. Chinese Journal of Information and Traditional Medicine, 2001 ;8 ( 6 ) :55.
29.	陈文英,覃怡.中西医结合治疗输卵管梗阻性不孕[J]中国中医药信息杂志,2001;8(6):55.
30.	［16］Yuan YM . Clinical observation of integrated traditional and western medicine for tubal subfertility[J]. Jiangxi J of TCM,2001 ;32(6) :53.
31.	袁悦明.中西医结合治疗输卵管阻塞临床观察[J].江西中医药,2001;32(6):53.
32.	［17］Zhou DQ. Blood-activating and coagulation-clearing for tubal infertility (56 cases) [J]. Guangming Zhongyi, 1997; (2):32-33.
33.	周端求.活血化瘀法治疗输卵管阻塞不孕症56例[J].光明中医,1997;(2):32～33.
34.	［18］Schulz KF, Chalmers l, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials[J]. JAMA, 1995; 273(5):408-412.
35.	［19］Vickers A, Goyal N, Harland R, Rees R Do certain countries produce only posifve results? A systematic review of controlled trials[J]. Control Clin Trials, 1998;19(2) :159-166.

1. ［1］Gao DL, Chen XF. Investigation of primary pregnancy rate and subfertility rate about 60 000 newly married women [ J ].Chin J 0bstet Gyneco , 1989 ;24(4) :234-235.
2. 高道利,陈霞飞六万新婚妇女初孕率和不孕率调查[J].中华妇产科杂志,1989;24(4):234～235.
3. ［2］Neville F. Hacker, J. George Moore. Essentials of obstetrics and gonaecology. See: David R. Meldrum: Infertility[M]. 3rd Ed.Philadelphia: W.B. Saunders Company,1998. 610-611.
4. ［3］Tang GL. Clinical analysis of tubal subfertility treated with Chinese traditional medicine[J]. Beijing J TCM, 2001 ;20(2) :36 ～37.
5. 唐桂兰.中药综合治疗输卵管炎性不孕症35例临床观察[J]北京中医,2001;20(2):36～37.
6. ［4］Wang TG, Feng DJ. Chinese traditional medicine for subfertility due to fallopian tube obstruction compared with western medicine (128cases) [J]. Hebei J TCM, 1995;17(4) :16-17.
7. 王廷国,冯冬菊中医辨证与西医对照治疗输卵管阻塞性不孕128例小结[J]河北中医,1995;17(4):16～17.
8. ［5］Lin J, Li KX, Zhang Y. Clinical analysis of Subfertility (58cases) due to fallopian tube obstruction treated with TCM[J].New Journal of Traditional Chinese Medicine, 1999; 31 ( 3 ):42-43.
9. 林洁,李克湘,张烨中药内外合治输卵管炎性不孕56例临床分析[J]新中医,1999;31(3):42～43.
10. ［6］Wang BP. Subfertility (300 cases) due to fallopian tube obstruction treated with Tong-Xiao-San [ J ]. Shandong J TCM, 1999 ;21 (2) :74-75.
11. 王本鹏.通消散冲剂治疗输卵管阻塞性不孕症300例[J].山东中医杂志,2002;21(2):74～75.
12. ［7］Kang JL, Xia W. Clinical study of fallopian tube obstruction treated with integrated traditional and western medicine [J ].Chinese Journal of Integrated Traditional and Western medicine,2001 ;21(6): 416-418.
13. 康佳丽,夏葳中西医结合治疗输卵管阻塞的临床研究[J].中国中西医结合杂志,2001;21(6):416～418.
14. ［8］Chen X. Sterility (68 cases) due to fallopian tube obstruction treated with TCM and Western medicine [J ]. Heilongjiang J TCM, 1997;20(4) :19.
15. 陈翔中西医结合治疗输卵管阻塞性不孕68例[J]黑龙江中医药,1997;20(4):19.
16. ［9］Liu YY. Analysis of effect on 102 infertile cases of nonspecific inflammation and oviduct obstruction with integrated traditional Chinese and western medicine [ J ]. Modern Journal of Integrated Traditional and Western Medicine , 2001; 10 ( 9 ):796-797.
17. 刘贻玉.中西医结合治疗非特异性炎症输卵管阻塞性不孕102例疗效分析[J]现代中西医结合杂志,2001;10(9):796～797.
18. ［10］Sui P. Subfertility (47 cases) due to chronic pelvic inflammation treated with TCM and Western medicine[J]. Liaoning J of TCM, 2001 ;20(5) :300.
19. 隋蓬.中西医结合治疗慢性盆腔炎性不孕47例[J].辽宁中医杂志,2001;20(5):300.
20. ［11］Peng SF, Li SF, Cai PJ. Blood-activating and Heat-clearing as a Main Therapy for Tubal Infertility[J]. Shanghai Journal of Traditional Chinese Medicine, 2000 ;34 ( 9 ) :23-25.
21. 彭少芳,李少芬,蔡佩君.活血清热法为主治疗输卵管阻塞性不孕症[J]上海中医药杂志,2000;34(9):23～25.
22. ［12］Liang Y. Medicine combined with acupuncture as the therapy for tubal subfertility[J]. Liaoning J of TCM, 2001 ;28(5) :294.
23. 梁燕针药并举治疗输卵管阻塞性不孕36例[J].辽宁中医杂志,2001;28(5):294.
24. ［13］Li M, Wu T. Clinical analysis of integrated traditional and western medicine for tubal inflammatory subfertility [ J ]. Chinese Journal of Information and Traditional Medicine, 2001 ;8 (2):57-58.
25. 李梅,吴霆.中西药内外合治输卵管炎性不孕临床分析[J].中国中医药信息杂志,2001;8(2):57～58.
26. ［14］Tu GC, Zhou Y. Report of injection in acupuncture point for fallopian obstruction (130 cases)[J]. Journal of Guiyang College of Traditional Chinese Medicine, 1997; 19 ( 4 ): 37-38.
27. 屠国春,周艳.穴位注射治疗输卵管阻塞130例报告[J].贵阳中医学院学报,1997;19(4):37～38.
28. ［15］Chen WY, Qin Y. Integrated traditional and western medicine for tubal subfertility [J ]. Chinese Journal of Information and Traditional Medicine, 2001 ;8 ( 6 ) :55.
29. 陈文英,覃怡.中西医结合治疗输卵管梗阻性不孕[J]中国中医药信息杂志,2001;8(6):55.
30. ［16］Yuan YM . Clinical observation of integrated traditional and western medicine for tubal subfertility[J]. Jiangxi J of TCM,2001 ;32(6) :53.
31. 袁悦明.中西医结合治疗输卵管阻塞临床观察[J].江西中医药,2001;32(6):53.
32. ［17］Zhou DQ. Blood-activating and coagulation-clearing for tubal infertility (56 cases) [J]. Guangming Zhongyi, 1997; (2):32-33.
33. 周端求.活血化瘀法治疗输卵管阻塞不孕症56例[J].光明中医,1997;(2):32～33.
34. ［18］Schulz KF, Chalmers l, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials[J]. JAMA, 1995; 273(5):408-412.
35. ［19］Vickers A, Goyal N, Harland R, Rees R Do certain countries produce only posifve results? A systematic review of controlled trials[J]. Control Clin Trials, 1998;19(2) :159-166.

Chinese Journal of Evidence-Based Medicine

Chinese Medicinal Herbs for Tubal Subfertility: A Systematic Review

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