Multi-Centre Randomized Controlled Trial of Bi Yuan Shu Liquid on Patients with Chronic Nasal Sinusitis or Nasal Polyp after Endosoopic Sinus Surgery_Chinese Journal of Evidence-Based Medicine

Authors：

LIANG Chuanyu ¹ , WEN Pei ² , ZHEN Yan ¹ , HE Gang ² , FAN Ming ³ , LI Wanrong ⁴ , TANG Siquan ⁵ , PENG Tao ⁶ , LIANG Guoqing ⁷ , WANG Jie ⁸ , ZHANG Yuping ⁹

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Keywords：

Bi Yuan Shu Liquid; Chronic nasal sinusitis/nasal polyp; Integrated west and Chinese medical treatment; Randomized controlled trial

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Objective 　To study the effect of Bi Yuan Shu Liquid on melioration of clinical symptoms and signs of chronic nasal sinusitis or nasal polyp patients after Functional Endosoopic Sinus Surgery (FESS), and discuss the effectiveness of Chinese composite medicine in the overall treatment after FESS.
Methods 　A total of 340 patients were randomly allocated to treatment group (n =170) and control group (n =170) according to simple randomization procedure. Patients in treatment group were administrated with quinolone, steroid, and Bi Yuan Shu Liquid, which were compared with those in control group who were given quinolone and steroid.
Results 　The apparent effect of treatment group and control group were 30.6% and 42.4% of 42.4% of ITT. Results by Wilcoxon signed rank test indicated that there was a statistically significant difference.
Conclusions 　Bi Yuan Shu Liquid may improve the effectiveness of sinus surgery, reduce the time course of antibiotics and hormones, and with out toxicity and side-effect.

Citation： LIANG Chuanyu,WEN Pei,ZHEN Yan,HE Gang,FAN Ming,LI Wanrong,TANG Siquan,PENG Tao,LIANG Guoqing,WANG Jie,ZHANG Yuping. Multi-Centre Randomized Controlled Trial of Bi Yuan Shu Liquid on Patients with Chronic Nasal Sinusitis or Nasal Polyp after Endosoopic Sinus Surgery. Chinese Journal of Evidence-Based Medicine, 2004, 04(6): 377-381. doi: Copy

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8.	陈绿琦.鼻渊舒治疗鼻炎鼻窦炎疗效观察[J].中国中西医结合耳鼻咽喉科杂志,2001;12(9专刊):23～24.

1. ［1］Zhang NZ, Xia LJ. Observe after FESS for adult and children who suffer from chronic sinusitis by using Bi Yuan Shu Liquid[J ]. China J Otolaryngol Ingegrat Trad&West Medi (special publication), 2001; 12(9): 10-12.
2. 张念祖,夏立军.鼻渊舒对成人、儿童慢性鼻窦炎与内窥镜鼻窦手术后的应用观察[J].中国中西医结合耳鼻咽喉科杂志,2001;12(9专刊):10～12.
3. ［2］Multi-center, random,parallel and contrast Clinical research staard for treating nose-Antral inflammation with GG ( glucocorticoid) and evaluating its effect and safty [ R]. ENT department of CMA (China Medical Association). 2001.
4. 鼻用糖皮质激素治疗鼻--鼻窦炎疗效和安全性评价之多中心、随机、平行对照临床研究标准[R].中华医学会耳鼻咽喉科分会.2001.
5. ［3］ENT department of CMA ( China Medical Association), Editorial Committee of China J Otolaryngol Medi. Clinical type and period of chronic sinusitis and nasal polyp &stadard of FESS (functional endoscopic sinus surgery) evaluation [J]. China J Otolaryngol Medicine, 1998; 33 (2): 133.
6. 中华医学会耳鼻咽喉科分会,中华耳鼻咽喉科杂志编辑委员会.慢性鼻窦炎鼻息肉临床分型分期及内窥镜鼻窦手术疗效评定标准[J].中华耳鼻咽喉科杂志,1998;33(2):133.
7. ［4］Chen LQ. Curative effectual observation of rhinitis and sinusits by using Bi Yuan Shu Liquid [ J ]. China J Otolaryngol Ingegrat Trad&West Medi ( special publication), 2001; 12 ( 9 ):23-24.
8. 陈绿琦.鼻渊舒治疗鼻炎鼻窦炎疗效观察[J].中国中西医结合耳鼻咽喉科杂志,2001;12(9专刊):23～24.

Chinese Journal of Evidence-Based Medicine

Multi-Centre Randomized Controlled Trial of Bi Yuan Shu Liquid on Patients with Chronic Nasal Sinusitis or Nasal Polyp after Endosoopic Sinus Surgery

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