Quasi-Randomized Controlled Trial of Integrated Traditional Chinese with Western Medicine for Acute Episodes of Withdrawal in Alcoholism_Chinese Journal of Evidence-Based Medicine

Authors：

DU Wanjun

National Drug Dependence Treatment Center; Beijing Anding Hospital Affiliated to Capital University of Medical Sciences; Beijing 100088; China;

Corresponding author：

Keywords：

Alcohol dependence; Integrated traditional Chinese with Western medicine

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Objective 　To compare the effectiveness of integrated traditional Chinese medicine (TCM) with Western medicine and Western medicine alone for acute episodes of withdrawal in alcoholism.
Methods 　According to the criteria of alcohol dependence and acute alcochol withdrawal syndrome of Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-Ⅳ) , 62 consecutive patients were divided into two groups: 31 patients with odd numbers were allocated to the treatment group (4 patients were excluded because they left hospital early), 31 patients with even numbers were allocated to the control group. According to the four diagnostic methods of TCM, all patients in the treatment group were further divided into 4 types. The treatment group received valium, tiopronin, transfusion therapy and herbs (potion per day). The control group received the same therapy as the treatment group did but without oral herbs.
Results 　Liver function, especially the difference between before and after treatment of GOT and γ-GT,the treatment group showed more improvement than the control group (P=0.046 and 0.001). The scores of anxiety and depression test, especially the HAMD, the treatment group showed more improvement than the control group (t=3.165, P=0.003). The treatment group used significantly less time than the control group (P=0.01), but no statistically significant difference was seen in the dosage of valium between the two groups (P=0.434).
Conclusions 　The efficacy of integrated TCM with Western medicine is better than Western medicine alone for acute episodes of withdrawal in alcoholism.

Citation： DU Wanjun. Quasi-Randomized Controlled Trial of Integrated Traditional Chinese with Western Medicine for Acute Episodes of Withdrawal in Alcoholism. Chinese Journal of Evidence-Based Medicine, 2004, 04(8): 541-544. doi: Copy

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4.	郭松,杜万君,王援朝,姜佐宁.酒依赖者认知功能障碍的事件相关电位研究[J].中国药物依赖性杂志,2001;10(4):271～273,314.
5.	［3］Chi Y, Guo S, Jiang ZN. The clinical characteristic, treatment and prognosis of 851 cases diagnosed as alcoholism [J].Chinese Journal of Drug Dependence, 2004; 13 ( 1 ): 41 - 45.
6.	迟勇,郭松,姜佐宁.851例住院酒相关精神障碍患者的临床特征及治疗转归[J].中国药物依赖性杂志,2004;13(1):41～45.
7.	［4］Ye YA,Tian DL. Explore the understand of traditional Chinese medicine about alcoholic liverish[J]. Transaction of Chinese Medicine, 1997; 5 (12): 8-10.
8.	叶永安,田德录.酒精性肝病中医认识初探[J].中国医药学报,1997;5(12):8～10.
9.	［5］Du WJ, Guo S. Advance of treatment of delirium tremens [J]. Chinese Journal of Drug Dependence, 2000; 9 (4) 246- 248.
10.	杜万君,郭松.震颤性谵妄的治疗进展[J].中国药物依赖性杂志,2000;9(4):246～248.
11.	［6］Linnoila MI. Pharmacological therapies of alcohol addiction [J]. J Psychiatry Research, 1990; 24: 121 - 127.

1. ［1］Jiang ZN, chief editor. Alcohol abuse and dependence [A].Contemporary psychiatry[M]. Beijing: Publishing House of Science, 1999: 528 - 533.
2. 姜佐宁,主编.酒滥用与酒依赖[A]现代精神病学[M].北京:科学出版社,1999:528～533.
3. ［2］Guo S, Du WJ, Wang YC, Jiang ZN. A study of cognitive impairment of alcoholics assessed by event related potential P300[J] . Chinese Journal of Drug Dependence, 2001; 10(4): 271-273, 314.
4. 郭松,杜万君,王援朝,姜佐宁.酒依赖者认知功能障碍的事件相关电位研究[J].中国药物依赖性杂志,2001;10(4):271～273,314.
5. ［3］Chi Y, Guo S, Jiang ZN. The clinical characteristic, treatment and prognosis of 851 cases diagnosed as alcoholism [J].Chinese Journal of Drug Dependence, 2004; 13 ( 1 ): 41 - 45.
6. 迟勇,郭松,姜佐宁.851例住院酒相关精神障碍患者的临床特征及治疗转归[J].中国药物依赖性杂志,2004;13(1):41～45.
7. ［4］Ye YA,Tian DL. Explore the understand of traditional Chinese medicine about alcoholic liverish[J]. Transaction of Chinese Medicine, 1997; 5 (12): 8-10.
8. 叶永安,田德录.酒精性肝病中医认识初探[J].中国医药学报,1997;5(12):8～10.
9. ［5］Du WJ, Guo S. Advance of treatment of delirium tremens [J]. Chinese Journal of Drug Dependence, 2000; 9 (4) 246- 248.
10. 杜万君,郭松.震颤性谵妄的治疗进展[J].中国药物依赖性杂志,2000;9(4):246～248.
11. ［6］Linnoila MI. Pharmacological therapies of alcohol addiction [J]. J Psychiatry Research, 1990; 24: 121 - 127.

Chinese Journal of Evidence-Based Medicine

Quasi-Randomized Controlled Trial of Integrated Traditional Chinese with Western Medicine for Acute Episodes of Withdrawal in Alcoholism

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