Objective To assess the effectiveness and safety of fukangpian in the treatment of opiate withdrawl symptoms.
Methods We performed an electronic search for Cochrane Library (2004 version of Cochrane Controlled Trials Register), Medline (1966-2004), EMbase (1974-2004), and handsearched some Chinese journals for additional articles (such as CBM disc, VIP, CNKI, CMCC) (1980-2004). The quality of included randomized controlled trials was evaluated and meta-analysis was performed.
Results We collected 31 studies about fukangpian, of which two studies involving 403 patients met the inclusion criteria. These two studies were of poor quality. Cmpared with clonidine, fukangpian showed a greater decrease than Clonidine group in the withdrawal symptom score for day 1 to day 4 (WMD of 9 points at day 4, 95%CI 5.47 to 12.52). Cmpared with placebo, the two studies for change in the withdrawal symptom score, fukangpian showed a greater decrease at day 1 to 3, but not at day 4 (WMD of 4.10 points at day 4, 95%CI -8.36 to 16.56; 1 study).
Conclusions Based on the current evidence fukangpian is an effective and safe drug for abstinence of drug addiction. More high quality randomized controlled trials are required to promote the strength of evidence.
Citation：
WANG Xue,LI SuXia,ZHU Sanping,LI Jin,KUANG Weihong,WU Taixiang. Systematic Review of Effectiveness and Safety of Fukangpian in the Treatment of Opiate Withdrawal Symptoms. Chinese Journal of Evidence-Based Medicine, 2004, 04(8): 545-549. doi:
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［1］Wang YD, Wang X. A study on efficacy of Fukangpian in thetreatment of opiate withdrawal symptoms[J]. Zhejiang Journal of Integrated Traditional with Western Medicine, 2001; 11 (4):204 - 206.
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王有德,王欣.福康片对阿片类戒断症状疗效的研究[J].浙江中西医结合杂志,2001;11(4):204～206.
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［2］Guo S, Jiang ZN, Wang YD, Hu GC, Wu YM, Huang MS.A comparative study of Chinese herbal medicine Fukangpian with clonidine hydrochloride on opiate withdrawal symptoms [J]. Chinses Bulletin of Drug Dependence, 1995; 4(4): 210 -216.
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郭松,姜佐宁,王有德,胡光才,吴艳梅,黄明生.中药福康片与盐酸可乐定治疗阿片类戒断症状的临床对照研究[J].中国药物依赖性通报,1995;4(4):210～216.
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［4］Cohen J. A coefficient of agreement for nominal scales[J ]. Educational and Psychological Measurement, 1960; 20 (1): 37 -46.
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［5］Aldeson P, Green S, Higgins JPT editors. Cochrane Reviews’Handbook 4.2.2 [ Updated December 2003 ] [ M/CD]. In:The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
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［6］Kang L, Li J, Huang MS. Random double blind test study of detoxicated effect of Kangfuxin, Fukangpian & clonidine hydrochloride on opiate withdrawal symptoms[J]. Chinese Journal of Clinical Rehabiliation, 2002; 6(23): 3 586-3 587.
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康林,李静,黄明生.中药康复新、福康片和可乐定对阿片类戒断症状的双盲对照研究[J].中国临床康复,2002;6(23):3 586～3 587.
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| 10. |
［7］Hu GC, Huang MS. Preliminary control study of detoxicated effect of Fukangpian on heroine addicts-clinical investigation of 40 cases [J]. Chinese Bulletin of Drug Dependence, 1995; 4(4): 217 -222.
|
| 11. |
胡光才,黄明生.福康片对海洛因依赖者脱毒的初步对照研究-附40例临床疗效观察[J].中国药物依赖性通报,1995;4(4):217～222.
|
- 1. ［1］Wang YD, Wang X. A study on efficacy of Fukangpian in thetreatment of opiate withdrawal symptoms[J]. Zhejiang Journal of Integrated Traditional with Western Medicine, 2001; 11 (4):204 - 206.
- 2. 王有德,王欣.福康片对阿片类戒断症状疗效的研究[J].浙江中西医结合杂志,2001;11(4):204～206.
- 3. ［2］Guo S, Jiang ZN, Wang YD, Hu GC, Wu YM, Huang MS.A comparative study of Chinese herbal medicine Fukangpian with clonidine hydrochloride on opiate withdrawal symptoms [J]. Chinses Bulletin of Drug Dependence, 1995; 4(4): 210 -216.
- 4. 郭松,姜佐宁,王有德,胡光才,吴艳梅,黄明生.中药福康片与盐酸可乐定治疗阿片类戒断症状的临床对照研究[J].中国药物依赖性通报,1995;4(4):210～216.
- 5. ［3］American Psychiatric Association. Diagnosis and Statistical Manual of mental Disorder[M]. 3rd edi. (revised). Washington DC: American Psychiatric Association Publications, 1987; 153- 154.
- 6. ［4］Cohen J. A coefficient of agreement for nominal scales[J ]. Educational and Psychological Measurement, 1960; 20 (1): 37 -46.
- 7. ［5］Aldeson P, Green S, Higgins JPT editors. Cochrane Reviews’Handbook 4.2.2 [ Updated December 2003 ] [ M/CD]. In:The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
- 8. ［6］Kang L, Li J, Huang MS. Random double blind test study of detoxicated effect of Kangfuxin, Fukangpian & clonidine hydrochloride on opiate withdrawal symptoms[J]. Chinese Journal of Clinical Rehabiliation, 2002; 6(23): 3 586-3 587.
- 9. 康林,李静,黄明生.中药康复新、福康片和可乐定对阿片类戒断症状的双盲对照研究[J].中国临床康复,2002;6(23):3 586～3 587.
- 10. ［7］Hu GC, Huang MS. Preliminary control study of detoxicated effect of Fukangpian on heroine addicts-clinical investigation of 40 cases [J]. Chinese Bulletin of Drug Dependence, 1995; 4(4): 217 -222.
- 11. 胡光才,黄明生.福康片对海洛因依赖者脱毒的初步对照研究-附40例临床疗效观察[J].中国药物依赖性通报,1995;4(4):217～222.
