Effect of Vitamin A Supplementation on Morbidity and Mortality in Children with Infectious Diseases_Chinese Journal of Evidence-Based Medicine

Authors：

YANG Huiming , WAN Chaomin

Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China Pediatrics Department, West China Second University Hospital, Sichuan University;

Corresponding author：

Keywords：

Vitamin A; Infectious disease; Morbidity; Mortality; Children; Clinical evidence

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Objective 　To evaluate the effect of vitamin A (Vit A) supplementation on the morbidity and mortality in children with infectious diseases.
Methods 　We searched Cochrane Library (Issue 1, 2004), MEDLINE (1966-2004.3) and The PedsCCM Evidence-Based Journal Club (1992-2002). Relevant systematic reviews and randomized controlled trials (RCTs) of Vit A supplementation on morbidity and mortality in children with infectious diseases were obtained.
Results 　We collected 107 studies and identified 13 systematic reviews or RCTs. The evidence showed that the effect of Vit A supplementation on morbidity and mortality was affected by the nutritional status of the children. Vit A supplementation given to Vit A deficient children could reduce the morbidity of diarrhea and mortality of measles. However, Vit A supplementation would increase the morbidity of diarrhoea and respiratory infections in children with sufficient nutrition.
Conclusions 　The nutritional status of children correlates with morbidity and mortality of some infectious diseases, and the nutritional status and serum Vit A level should be evaluated before Vit A supplementation applied.

Citation： YANG Huiming,WAN Chaomin. Effect of Vitamin A Supplementation on Morbidity and Mortality in Children with Infectious Diseases. Chinese Journal of Evidence-Based Medicine, 2004, 04(9): 644-647. doi: Copy

1.	［1］Chowdhury S, Kumar R, Ganguly NK, Kumar L, Walia BN. Effect of vitamin A supplementation on childhood morbidity and mortality[J]. Indian Journal of Medical Sciences, 2002; 56 (6): 259-264.
2.	［2］Sommer A, Tarwotjo I, Djunaedi E, West KP Jr, Loeden AA, Tilden R, Mele L. Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial[J]. Lancet, 1986; 1 (8491): 1 169-1 173.
3.	［3］Rahmathullah L,Underwood BA,Thulasiraj RD, Milton RC, Ramaswamy K, Rahmathullah R, Babu G. Reduced mortality among children in Southern India receiving a small weekly dose of vitamin A[J]. The New England Journal of Medicine, 1990; 323 (14): 929-935.
4.	［4］Stansfield SK, Pierre-Louis M, Lerebours G,Augustin A. Vitamin A supplementation and increased prevalence of childhood diarrhoea and acute respiratory infections[J]. Lancet, 1993; 342 (8871): 578-582.
5.	［5］Herrera MG, Nestel P, El Amin A, Fawzi WW, Mohamed KA, Weld L. Vitamin A supplementation and child survival[J]. Lancet, 1992; 340 (8814): 267-271.
6.	［6］Barreto ML, Santos LM, Assis AM, Araujo MP, Farenzena GG, Santos PA, Fiaccone RL. Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil[J]. Lancet, 1994; 344 (8917): 228-231.
7.	［7］Dibley MJ, Sadjimin T, Kjolhede CL, Moulton LH. Vitamin A supplementation fails to reduce incidence of acute respiratory illness and diarrhea in preschool-age Indonesian children[J]. The Journal of Nutrition, 1996; 126 (2): 434-442.
8.	［8］Semba RD, Akib A, Beeler J, Munasir Z, Permaesih D, Muherdiyantiningsih, Komala, Martuti S, Muhilal. Effect of vitamin A supplementation on measles vaccination in nine-month-old infants[J]. Public Health, 1997; 111 (4): 245-247.
9.	［9］Coutsoudis A, Adhikari M, Pillay K, Kuhn L, Coovadia HM. Effect of vitamin A supplementation on morbidity of low-birth-weight neonates[J]. South African Medical Journal, 2000; 90 (7): 730-736.
10.	［10］D’Souza RM, D’Souza R. Vitamin A for treating measles in children (Cochrane Review) [M/CD]. In: The Cochrane Library, Issue 1, 2004.
11.	［11］Mahalanabis D, Lahiri M, Paul D, Gupta S, Gupta A, Wahed MA, Khaled MA. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection[J]. American Journal of Clinical Nutrition, 2004; 79 (3): 430-436.
12.	［12］West KP Jr, Pokhrel RP, Katz J, LeClerq SC, Khatry SK, Shrestha SR, Pradhan EK, Tielsch JM, Pandey MR, Sommer A. Efficacy of vitamin A in reducing preschool child mortality in Nepal[J]. Lancet, 1991; 338 (8759): 67-71.
13.	［13］Ghana VAST Study Team. Vitamin A supplementationin northern Ghana: effects on clinic attendances, hospital admissions, and child mortality[J]. Lancet, 1993; 342 (8 862): 7-12.

1. ［1］Chowdhury S, Kumar R, Ganguly NK, Kumar L, Walia BN. Effect of vitamin A supplementation on childhood morbidity and mortality[J]. Indian Journal of Medical Sciences, 2002; 56 (6): 259-264.
2. ［2］Sommer A, Tarwotjo I, Djunaedi E, West KP Jr, Loeden AA, Tilden R, Mele L. Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial[J]. Lancet, 1986; 1 (8491): 1 169-1 173.
3. ［3］Rahmathullah L,Underwood BA,Thulasiraj RD, Milton RC, Ramaswamy K, Rahmathullah R, Babu G. Reduced mortality among children in Southern India receiving a small weekly dose of vitamin A[J]. The New England Journal of Medicine, 1990; 323 (14): 929-935.
4. ［4］Stansfield SK, Pierre-Louis M, Lerebours G,Augustin A. Vitamin A supplementation and increased prevalence of childhood diarrhoea and acute respiratory infections[J]. Lancet, 1993; 342 (8871): 578-582.
5. ［5］Herrera MG, Nestel P, El Amin A, Fawzi WW, Mohamed KA, Weld L. Vitamin A supplementation and child survival[J]. Lancet, 1992; 340 (8814): 267-271.
6. ［6］Barreto ML, Santos LM, Assis AM, Araujo MP, Farenzena GG, Santos PA, Fiaccone RL. Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil[J]. Lancet, 1994; 344 (8917): 228-231.
7. ［7］Dibley MJ, Sadjimin T, Kjolhede CL, Moulton LH. Vitamin A supplementation fails to reduce incidence of acute respiratory illness and diarrhea in preschool-age Indonesian children[J]. The Journal of Nutrition, 1996; 126 (2): 434-442.
8. ［8］Semba RD, Akib A, Beeler J, Munasir Z, Permaesih D, Muherdiyantiningsih, Komala, Martuti S, Muhilal. Effect of vitamin A supplementation on measles vaccination in nine-month-old infants[J]. Public Health, 1997; 111 (4): 245-247.
9. ［9］Coutsoudis A, Adhikari M, Pillay K, Kuhn L, Coovadia HM. Effect of vitamin A supplementation on morbidity of low-birth-weight neonates[J]. South African Medical Journal, 2000; 90 (7): 730-736.
10. ［10］D’Souza RM, D’Souza R. Vitamin A for treating measles in children (Cochrane Review) [M/CD]. In: The Cochrane Library, Issue 1, 2004.
11. ［11］Mahalanabis D, Lahiri M, Paul D, Gupta S, Gupta A, Wahed MA, Khaled MA. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection[J]. American Journal of Clinical Nutrition, 2004; 79 (3): 430-436.
12. ［12］West KP Jr, Pokhrel RP, Katz J, LeClerq SC, Khatry SK, Shrestha SR, Pradhan EK, Tielsch JM, Pandey MR, Sommer A. Efficacy of vitamin A in reducing preschool child mortality in Nepal[J]. Lancet, 1991; 338 (8759): 67-71.
13. ［13］Ghana VAST Study Team. Vitamin A supplementationin northern Ghana: effects on clinic attendances, hospital admissions, and child mortality[J]. Lancet, 1993; 342 (8 862): 7-12.

Chinese Journal of Evidence-Based Medicine

Effect of Vitamin A Supplementation on Morbidity and Mortality in Children with Infectious Diseases

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