Assessment of clinical effects of naloxone in treating patients with acute cerebral infarction_Chinese Journal of Evidence-Based Medicine

Authors：

WEI Yongsheng , YANG Yousong , LUO Yongjie , XIAO Jun , SUN Hongbin , GUO Fuqiang , DAI Hongyuan

Department of Neurology Sichuan Provincial Hospital; Chengdu 610031; China;

Corresponding author：

Keywords：

Naloxone; acute cerebral infarction; randomized controlled trial

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Objective 　To assess the effect of naloxone in treating the disease of acute cerebral infarction.
Methods 　Sixty patients of acute cerebral infarction were randomly divided into two groups. One group received routine therapy and the other routine therapy plus naloxone. Neuroprotective effect of naloxone were measured by using NIH stroke scale and Bathel-Index. Adverse effect of the drug was also observed.
Results 　There were 27 patients (90%) improved with clinical manifestations in experiment group, and 20 patients (67%) improved in control group. There is a significant difference between the two groups (P lt;0.05).There is no adverse reactions of naxloxone observed.
Conclusion 　Naloxone might protect the nervous cells and restore the function of the nervous system in patients with acute cerebral infraction.

Citation： WEI Yongsheng,YANG Yousong,LUO Yongjie,XIAO Jun,SUN Hongbin,GUO Fuqiang,DAI Hongyuan. Assessment of clinical effects of naloxone in treating patients with acute cerebral infarction. Chinese Journal of Evidence-Based Medicine, 2003, 03(3): 178-180. doi: Copy

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1. ［1］宋扬,沈洪纳络酮脑保护作用的研究现状[J].脑血管疾病杂志2002,2(2):95-97.
2. ［2］吴波,刘鸣脑卒中临床试验疗效判定现状及趋势[J].中华神经科杂志2002,35(3):177-179.
3. ［3］潘涛,张龙,等,急性脑梗死病人血清中Mg2+浓度变化的研究[J].卒中与神经疾病2002,9(6):370-371.
4. ［4］全国第四届脑血管病学术会议,脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志1996:12(6):381-383.
5. ［5］Tseng EE, Brock MV, Kwon CC, et al. Increased intracerbral excitatory amino acids and nitric oxide after hypothermic circulatory arrest[J].Ann Thorac Surg 1999;67:371-376.
6. ［6］Chen C J, Cheng FC, Liao SL, et al. Effects of naloxone on lactate,pyruvate metabolism and antioxidant enzyme activity in rat cerebral ischemia/reperfusion[J]. Neurosucience Letters 2000;287:113- 116.
7. ［7］Tymianski M, Tator CH. Normal and abnormal calcium homeostasis in neurons:a basis for the pathophysiology of traumatic and ischemic central nervous system injury[J].Neurosurg 1996;38:1176-1195.

Chinese Journal of Evidence-Based Medicine

Assessment of clinical effects of naloxone in treating patients with acute cerebral infarction

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