- 1. Key Lab of Transplant Engineering and Immunology (Ministry of Health; China); West China Hospital; Sichuan University; Chengdu; 610041; China2. West China School of Clinical Medicine; Sichan University; Chengdu; 610041; China3. The Chinese Cochrane Center; Sichan University; Chengdu; 610041; China4. Center for Drug Re-evaluation; State Food and Drug Administration of China; Beijing 100038;
Objective This review compared clinical effectiveness, cardiac safety and economics of astemizole, loratadine, cetirizine and terfenadine to provide evidence for adjustment of Essential Drug List in China.
Search strategy We searched Medline, Cochrane Library, Embase and Chinese Biomedical Database. Fourteen databases for drug safety and pharmaceutical economics were additionally searched. Selection Criteria Randomized controlled trials and systematic reviews, published in English and Chinese and comparing two or more of these four antihistamines for allergic rhinitis and urticaria were included for study of effectiveness. Non-randomized clinical trials were additionally included for economic evaluation. Cardiac safety studies of antihistamines for allergic diseases of any type were included.
Quality Appraisal Jadad scale was primarily applied to randomized controlled trials. Allocation concealment and intention-to-treat analysis were also appraised. The QUOROM statement was applied to systematic reviews and meta-analysis.
Data extraction and analyses For the study of effectiveness, composite data were primarily extracted and analyzed by fixed effect model. Sensitivity analysis was done to explore the heterogeneity. For the study of cardiac safety, cases of adverse drug reactions and death were summarized. Difference of occurrence rate in sex and age were analyzed if possible.Electrocardiography and clinical symptoms were summarized.
Results No studies on economic evaluation were identified. 27 and 6 randomized controlled trials, including 3 227 participants, for allergic rhinitis and urticaria were identified. Cetirizine was superior to loratadine (n=709) in symptom score and onset of action, superior to terfenadine (n=645) in Quality of Life and superior to astemizole (n=498) in patient satisfaction and onset of action. 73 h-ADR cases were identified in astemizole, 27 cases in terfenadine, 1 case in loratadine and none in cetirizine. No deaths were identified. Combination of terfenadine plus grapefruit juice (n=l8), itraconazole (n=6), nefazodone (n=67), and loratadine administration concomitant with cemitidine (n=30) significantly prolonged QTc interval.
Conclusions Cetirizine was superior to other three antihistamines in terms of clinical effectiveness and drug safety. Astemizole and terfenadine could cause significantly more cardiac-related adverse reactions than cetirizine and loratadine.
Citation: SUN Xin,CAO Liya,MA Tao,LAN Fen,LI Xia,XIAO Aili,CHEN Xinzu,LI Youping. Health technology assessment of four non-sedating antihistamines for allergic diseases. Chinese Journal of Evidence-Based Medicine, 2003, 03(3): 195-206. doi: Copy
1. | [1]Andrew’ s Diseases of the Skin[M]. 4 edition, 160. |
2. | [2]Bellanti JA; Wallerstedt DB. Allergic rhinitis update: Epidemiology and natural history[J]. Allergy-Asthma-Proc 2000; 21(6): 367-370. |
3. | [3]Stempel DA; Woolf R. The cost of treating allergic rhinitis[J]. CurrAllergy-Asthma-Rep. 2002; 2(3): 223-230. |
4. | [4]Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis[J]. J-Allergy-Clin-Immunol. 2001 Jul;108(1 Suppl): S2-S8. |
5. | [5]Monroe EW. Loratadine in the treatment of urticaria[J]. Clin-Ther 1997; 19(2): 232-242. |
6. | [6]Merk HF. Standard treatment: the role of antihistamines[J]. JInvestig-Dermatol-Symp-Proc 2001; 6(2): 153-156. |
7. | [7]Woosley RL. Cardiac actions of antihistamines[J]. Ann Rev Pharmacol Toxicol 1996;36:233-252. |
8. | [8]Lacerda AE, Roy ML, Lewis EW, Rampe D. Interaction of the nonsedating antihistmine loratadine with a Kv1.5-type potassium channel cloned from human heart[J]. Mol Pharmacol 1997; 52:314-322. |
9. | [9]Delpon E, Valenzuela C, Pilar G, Franqueza L, Snyders DJ, Tamargo J. Block of human cardiac Kv1.5 channels by loratadine: voltage-,time-, and use-dependant block at concentrations above therpeutic levels[J]. Cardiovasc Res 1997; 35: 341-350. |
10. | [10]Pratt CM, Hertz RP, Ellis BE, Crowell SP, Louv W, Moye L. Risk of developing life-threatening ventricular arrhythmia associated with terfenadine in comparison with over-the counter anithistaminess,inbuprofen and clematine[J]. Am J Cardiol 1994; 73: 346-352. |
11. | [11]Howarth PH, Holgate ST. Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever[J]. Thorax 1984; 39: 668-672;. |
12. | [12]Novembre E, Bernardini R, Marano EA, vergallo IG, Vierucci A.Comparative efficacy and tolerability of terfenadine versus astemizole in the treatment of seasonal allergic rhino-conjunctivitis in children[J]. Current Therapeutic Research 1990; 47 (5). |
13. | [13]Boland N. A double-blind study of astemizole and terfenadine in the treatment of perennial rtinitis[J]. Annals of Allergy 1988; 61. |
14. | [14]Girard JP, Sommacal-Schopf D, Bigliardi P, Henauer SA. Doubleblind comparison of astemizol, terfenadine and placebo in hay fever with special regard to onset of action[J]. J Int Med Res 1985; 13(102). |
15. | [15]Wood SF. Astemizole and terfenadine compared in hay fever[J]. The pratitioner 1986; 230. |
16. | [16]Oei HD. Double-blind comparison of loratadine (SCH29851),Astemizole, and placebo in hay fever with special regaid to onset of action[J]. Annals of Allergy 1988; 61. |
17. | [17]Lee STS, Amin MJ. Efficacy and safety of loratadine compared with astemizole in malaysion patients with allergic rhinitis[J]. Singapore MedJ 1994; 35:591-594. |
18. | [18]The LASAR Study Group. Double-blind comparison of the efficacy and safety of astemizole and loratadine in the treatment of seasonal allergic rhinitis[J]. Drug Invest. 1992; 4 (4):336-345. |
19. | [19]Muhaimeed HA1. Aparallel-group comparison of astemizole and loratadine for the treatment of perennial allergic rhinitis[J]. The Journal of International Medical Research 1997; 25: 175-181. |
20. | [20]Chervinsky P, Georgitis J, Banov C, Boggs P, Vande Stouwe R, and Greenstein S. Once daily loratadine versus astemizole once daily[J].Annals of Allergy 1994; 73. |
21. | [21]Harcup JW, Hawkes G, Saul PA, Dr Harcup JW .The efficacy and sedative profile of Astemizole and Cetirizine in the treatment of grass pollen hayfever in general practice. General Practitioner, The Surgery, Court Road, Malvern, Walvern, Worcs, WR14 3BL. |
22. | [22]Berkowitz RB, Dockhorn R, Lockey R, Findlay S, Howland WC,Mitchell DQ, Woehler T. Comparison of efficacy, safety, and skin test inhibition of cetirizine and astemizole[J]. Ann Allergy Asthma Immunol1996; 76: 363-368. |
23. | [23]Carpio JD, Kabbash L, Turenne Y, Prevost M, Hebert J, Bedard PM,Nedilsk MI, Gutkowski A, Schulz J. Efficacy and safety of loratadine (10 mg once daily), terfenadine (60 mg twice daily), and placebo in the treatment of seasonal allergic rhinitis[J]. J Allergy Clin Immunol 1989; 5 (84): 742-746. |
24. | [24]Horak F , Bruttmann G, Pedrali P, Weeke B, Frolund L, Wolff H,Christtophers E. A Multicentric Study of Loratadine, Terfenadine and Placebo in Patients with Seasonal Allergic Rhinitis. |
25. | [25]Gutkowski P, Bedard J, Carpio D, Hebert J, Prevost M, Schulz J,Turenne Y, Yeadon C. Comparison of the efficacy and safety of loratadine, terfenadine, and placeb in the treatment of seasonal allergic rhinitis[J]. JAllergy Clin Immuno 1998; 5(81): 902-907. |
26. | [26]Estelle F ,Simons R, Frcpc , Janice L, Lukowskl BN, Becker AB,Keith JS. Comparison of the effects of single doses of the new H1receptor antagonists loratadine and terfenddine versus placebo in children. Clinical and laboratory observations[J]. The Journal of Pediatrics 1991. |
27. | [27]Estelle F ,Simons R, Janice L, Lukowskl BN, Becker AB, Keith JS .Comparison of the effects of single doses the new H1-receptor antagonists loratadine and terfenadine versus placebo in childen[J].The Journal of Pediatrics 1991. |
28. | [28]Day JH, Briscoe M, Widlitzm MD, Cetirizine , loratadine, or placebo in subjects with seasonal allergic rhinitis: Effects after corrolled ragweed pollen challenge in an environmental ecposure unit[J]. J Allergy Clin Immunol 1998; 5 (101): 638-645. |
29. | [29]Persl L, Demoly P, Alan G, Bernard H, Francois T, Michel B,Bousquet J. Comparison between nasal provocation tests and skin tests in patients treated with lortadine and cetirizine[J]. J Allergy Clin Immunol 1999; 103: 591-594. |
30. | [30]Meltzer EO, Weiler JM, Widlitz MD. Comparative outdoor study of the efficacy, onset and duration of action, and safety of cetirizine,loratadine, and placebo for seasonal allergic rhinitis[J]. J Allergy Clin Immunol 1996; 97; 617-626. |
31. | [31]Chaweewan B, Jareonchai P ,Dhorranintra B. A Clinical Comparison of cetirizine versus astemizole in perennial allergic rhinitis[J]. Drug Invest. 1993; 5 (4); 222-228. |
32. | [32]Rijntjes E, Ghys L, Rihoux JR Astemizole and cetirizine in the treatment of seasonal allergic rhinitis: a comparative double-blind, multicentre study[J]. The Journal of International Medical Research 1990; 18:219-224. |
33. | [33]Lockey RF, Widlitz MD, Mitchell DQ, Lumry W, Dockhorn R,Woehler T, Grossman J. Comparative study of cetirizine and terfenadine versus placebo in the symptomatic management of seasonal allergic rhinitis[J]. Annals of Allergy, Asthma, & Immunology 1996;76: 448-454. |
34. | [34]Renton R, Fidler C, RosenbergR. Multicenter, crossover study of the efficacy and tolerability of terfenadine, 120 mg, versus cetirizine, 10mg, in perennial allergic rhinitis[J]. Annals of Allergy 1991; 67. |
35. | [35]Backhouse CI, Renton R, Fidler C, Rosenberg RM. Multicentre, double-blind comparison of terfenadine and cetirizine in patients with seasonal allergic rhinitis[J]. BJCP 1990; 44 (3). |
36. | [36]Andri G, Senna E, Betteli C, Givanni S, Andri G, Lombardi C,Mezzelani P. A comparison of the efficacy of cetirizine and terfenadine[J]. Allergy 1993; 48: 358-365. |
37. | [37]Bruuttmann G, Charpin D, Germouty J, Horak F, Grenoble GW.Evaluation of the efficacy and safety of loratadine in perennial allergic rhinitis[J]. JAllergy Clin Immunol 1989; 83:411-416. |
38. | [38]Macchia L, Maria FC, Paola RD, Michele GD, Bariletto G. Secondgeneration antihistamines in the treatment of seasonal allergic rhinitis due to parietaria and cypress pollen[J]. Pharmacological Research 2001; 1 44 (6). |
39. | [39]Harvet RP, Coner C, Sanders B, Westley R, Marsh W, Shapiro H,Phd, Wiener M, Pharmd. Model for outcomes assessment of antihistamine use for seasonal allergic rhinitis[J]. J Allergy Clin Immunol 1996; 97: 1233-1241. |
40. | [40]Day JH, Briscoe MP, Reginald HC, Ellis AK, Gervais P. Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis[J]. Ann Allergy Asthma Immunol 1997; 79:163-172. |
41. | [41]Ciprandi G, Pronzato C, Ricca V, Danzig P M, Canonica GW.Loratadine treatment of rhinitis due too pollen allergy reduces epithelial ICAM-1 espression[J]. Clinical and Experimental Allergy 1996;27: 1175-1183. |
42. | [42]Saviuc P, Danel V, Dixmerias F. Prolonged QT interval and Torsade de pointes following Astemizole overdose[J]. Clinical Toxicology 1993;31(1):121-125. |
43. | [43]Broadhurst P, Nathan AW. Cardiac arrest in a young woman with the long QT syndrome and concomitant astemizole ingestion[J]. BRHEART-J 1993; 70: 469-470. |
44. | [44]Sakemi H, VanNatta B, Beach L. Torsade de points induced by astemizole in a patient with prolongation of the QT interval.American HeartJounal 1993 May; 125(5): 1436-1438. |
45. | [45]Clark A, Love H. Astemizole-induced ventricular arrhythmias: an unexpected cause of convulsions[J]. Intetnal Journal of Cardiology 1991; 33: 164-165. |
46. | [46]Tobin JR, Doyle TP, Ackerman AD, Brenner JI. Astemizole-induced cardiac conduction disturbances in a child[J]. JAMA 1991; 266(19):2737-2740. |
47. | [47]ZHOU YU-lang(周于浪),ZOU Qin(邹勤).1 case severe allergy caused by astemizole(息斯敏致严重过敏1例)[J].The InternedicateMedicalJournal(中级医刊)1995;30(4):59. |
48. | [48]TAI Chang-yun(太昌允),JIN En-shi(金恩实).One case of one-degree atrioventricular block with bradycardia caused by astemizole(阿司咪唑致Ⅰ度房室传导阻滞伴严重心动过缓1例)[J]ChineseJournal of New Drugs(中国新药杂志)1995;4(1):49. |
49. | [49]ZHAO Hui-ping(赵惠平)One case of hematuria caused by astemizole(阿司咪唑致血尿1例)[J].YAOWU LIUXINGBINGXUEZAZHI(药物流行病学杂志)1994;3(3):169. |
50. | [50]TIAN Ren-fa(田仁发)One case of allergic shock by astemizole (阿司咪唑致过敏性休克1例)[J].Chinese Journal of Hospital pharmacy(中国医院药学杂志)1995;15(1):522. |
51. | [51]WANG Chun-ming(王春明),WEI Tie-ming(韦铁民).One case of QTc prolongation and tosade de pointes caused by astemizole (阿司咪唑致QT间期延长伴尖端扭转型室性心动过速一例)[J].Chinese Journal of Cardiac Pacing and Electrophysiology (中国心脏起博与心电生理杂志)2000;14(4):249. |
52. | [52]XU Cheng-wen (徐成文) . One successful salvage of cardiac arrest caused by astemizole intoxication(阿司咪唑中毒致心跳骤停抢救成功1例)[J].Chinese Journal of Hospitalpharmacy(中国医院药学杂志)1995;15(10):476477. |
53. | [53]YIN Li-xin(殷立新),ZHAOZhi(赵智),KANGZe-kun(亢泽h ) .52 case series of adverse drug reactions by astemizole ( 阿司咪唑不良反应52例分析)[J].China Pharmacist(中国药师)2000;3(6):358-359. |
54. | [54]YANG Hua (杨华) . One case of torsade de pointes caused by overdose Hi smanal(息斯敏中毒致尖端机转型室速一例)[J].Medical Research Proceedings(医学研究通讯)1996;25(4):31-32. |
55. | [55]CHI Jun-ling(迟军玲),YI Zhong-zhi(仪忠直),ZHANG Rui ( 张蕊 ) . One case of epilepsy like episode caused by overdos of hismanl(息斯敏过量致癫痫样发作1例报告)[J].Journal of Clinical Neurological Electrophysiology(临床神经电生理学杂志)2001 ,2; 10( 1 ). |
56. | [56]ZHENG Hou-lin (郑厚林),LU Xiao-feng(鲁小峰),WAN Bin(万斌)One case of allergic shock caused by astemizole(阿司咪唑致过敏性休克1例)[J].Ning Bo Medicine(宁波医学)1 999;9(4). |
57. | [57]PAN Ming-kang(潘明康)One case oftorsade de pointes cuased bylarge dose astemizole(大剂量阿司咪唑诱发尖端扭转型室性心动过速1例)[J].Tie Dao Medicine(铁道医学)1996 10;24(5). |
58. | [58]GAO Xiang(高翔),LIU Hong-qin(刘鸿琴),ZHAO Li一mei (肇丽梅)One case of allergie shock by astemizole(阿司咪唑引起过敏性休克1例)[J].YAOWULIUXINGBINGXUEZAZHI(药物流行病学杂志)1996;5(3). |
59. | [59]GU Ai-ming(顾爱明)Astemizoleinduced QTc prolongation.two cases(阿司咪唑致心电图Q-T间期延长一附2例报告)[J].Journal of Clinical Dermatology(临床皮肤科杂志)1998;27(4). |
60. | [60]YANG Chuan Ying(杨传英),Duan Zhi-rong(段志荣).One case of angina pectoris caused by astemizole(阿司咪唑诱发心绞痛1例)[J].CapitalMedicine(技术交流学术研究)1998;5(11):36. |
61. | [61]Wang Yong(王勇),WANG Hong-Lin(王洪林),DU Ling-yun (杜凌云).Severe low potassium syndrome caused by astemizole (阿司咪唑致严重低钾血症1例)[J].Chinese Journal of New Drug and Clinical Medicines(中国新药与临床杂志)1999;18(1):63. |
62. | [62]ZHANG Yuan(张媛),FU Xia(付霞),WANG Rui-ru(王瑞儒),ZHAO Ming-wu(赵鸣武)Two cases of torsade de pointes by astemizole(阿司咪唑致尖端扭转性室性心动过速二例)[J].Chinese Journal of Internal Medicine(中华内科杂志)1995;34(7):484-485. |
63. | [63]Goss JE, Ramo BW, Albuquerque BK. Torsades de points associated with Astemixole (hismanal) therapy[J]. ARCH-INTERN-MED 1993.13:153. |
64. | [64]LIU Guang-hui(刘光辉)One case oftorsade de pointes caused by overdose of hismanal(息斯敏中毒致扭转型室速1例报告)[J].Journal of Xi’an Medical College(西安医科大学学报).17:162. |
65. | [65]ZONG Wei-zhen(宗卫珍)One case of supraventriculartachycardia caused by hismanal(息斯敏致室上性心动过速1例)[J].Journal ofClinical Dermatology(临床皮肤科杂志)1997;5:343. |
66. | [66]SONG Wei-zhen(宋卫珍)Supraventricular tachycardia caused by hismanal(息斯敏致室上性心动过速1例)[J].Chinese J Derm Venereol(中国皮肤性病学杂志)1999;13(2):120. |
67. | [67]WU Fang-ping(吴芳萍),ZHOU Ling(周玲).LI Shi-yin(李世滢).One case of epilepsylike episode caused by overdosof hismanal(息斯敏过量致癫痫样发作1例报告)[J].Journal of Clinical Elctroencephaloly(临床脑电学杂志)2000;9(4):224. |
68. | [68]TANG Yan-hong(唐艳红)One case of torsade de pointes caused by overdose of hismanal(息斯敏药物中毒致尖端扭转型室速一例报告)[J].Chinese Medicine of Factory and Mine(中国厂矿医学)1996;4:285. |
69. | [69]TIAN Ji-xian(国继先)LIE Deng-shan(雷登山),ZHANG Jiajie(张家界).One case of torsade de pointes caused by Hismanal (息斯敏中毒致尖端扭转型室速1例)[J].Journal of Internal Intensive Medicine(内科急危重症杂志)4;(4):183. |
70. | [70]Sintonen SP, Vitasalo M, Toivonen L, Neuvonen P. Itraconazole prevents tefernadine metabolism and increases risk of torsades de pointes ventricular tachycardia[J]. BMJ-CLIN-PHARMACOL 1993;45: 191-193. |
71. | [71]Feroze H, Suri R, Siverman DI. Torsades de points from tefernadine and sotalol given in combination[J]. PACE 1996; 19:1519-1521. |
72. | [72]Koh K K, Faca F, Rim MS, Yoon J, Kim S S. Torsade de pointes induced by tefernadine in a patient with long QT syndrome[J].Journal of Electrocardiology 1994; 27(4): 343-346. |
73. | [73]Crane J K, Shih HT. Syncope and cardiac arrhythmia due to an interaction between itraconazole and tefernadine[J]. The American Journal of Medicine 1993; 95: 445-446. |
74. | [74]Kamisako T, Adachi Y, Nkagawa H, Yamamoto T.Torsades de pointes associated with tefernadine in a case of liver cirrhosis and hepatocellular carcinoma[J]. INTERNAL MEDICINE 1995; 34(2):92-95. |
75. | [75]Peter K.Honig, D C. Hull W R, Zamani K, Smith J E., Cantilena L R.. Itraconazole affects single-dosa tefernadine pharmacokinetics and cardiac repolarization pharmacodynamics[J]. J-CLIN-PHAR 1993;33: 1201-1206. |
76. | [76]June RA, Nasr I.Torsades de pointes with tefernadine ingestion. |
77. | [77]ZHANG Feng-ru(张凤如),SHEN Wei-feng(沈卫峰)One case oftorsade de pointes caused bytefernadine(特非那丁引起扭转型室速1例)[J].Jounal of Clinical Electrocardiology(临床心脏电生理学杂志)1995;4(3):120. |
78. | [78]ZHANG S u-ping(章素萍)Repeated syncopal episodes withtorsade de poonted caused by astemziole,case report(阿司咪唑中毒致尖端扭转型室速反复发作性晕厥1例)[J].Chinese Journal of New Drugs(中国新药杂志)1996;5(3):215. |
79. | [79]XU Cheng-wen(徐成文)One case of successful salvage of car diac arrest caused by hismanal mtoxicaton(息斯敏中毒心跳骤停抢救成功1例)[J].Jiang Su Medicine(江苏医药)1995;2(10):672. |
80. | [80]XU Xing-shu(徐性述),WANG Xiao-ping(王晓萍)one caseof allergic shock caused by hismanal(抢救息斯敏致过敏性休克一例)[J].Chinese Journal of Pediatrics(中华儿科杂志)1995;33(6):383. |
81. | [81]WANGXin-yi(汪新义)Two cases of severe headache byteferna-dine(特非那丁引起剧烈头痛2例)[J].The Chinese Journal ofDermatovenereology(中国皮肤性病学杂志)1995;9(3):186. |
82. | [82]DU Xiu-ying(杜秀英),DUAN Shu-lan(段淑兰)One case of allergic shock caused by hismanal(息斯敏致过敏性休克一例报告)[J].MedicalJournal of Qinghai(青海医药杂志)1996;161:8. |
83. | [83]XIANG Chun-Tao(向春桃)One case of epilepsy-like episode caused by oral hismanal(口服息斯敏引起癫痫样发作1例)[J].Medical Theoryand Practice(医学理论与实践)1998;11(2):562. |
84. | [84]HUANG Jian-ming(黄建明)Two cases of Paroxysmal ventriculartachycardia caused by teldane(特非那定致阵发性心动过速2例报告).NewMedicine(新医学)1999;30(3):145. |
85. | [85]LIU Zhao-ying(刘兆英),LUO Yan-hong(罗延宏),WANG Ying-zhong(王应忠)One case of Torsade de pointes(特非那丁致扭转性心动过速1例)[J].JournalofClinical Cardiology(China)(临床心脏病学杂志)1999;1 5(1):20. |
86. | [86]CHEN Lian-zhen(陈莲珍)Death case caused by combinationof terfeandine and grapefruitjuice(特非那定与葡萄水果汁相互作用致死1例)[J].Chinese Journal of Clinical Pharmacy(中国临床药学杂志) 1999;8(1):42. |
87. | [87]HUANG Wen-hui(黄文辉),ZHAN Xue-bing(詹学斌).One case of torsade de pointes caused by terfeandine(特非那丁诱发尖端扭转型室速1例)[J].ZHE JIANG ZHONG XI YI JIE HE ZA ZHI(浙江中西医结合杂志)1999;9(4):272. |
88. | [88]WANYu-ming(万雨明),LI Ming(李明)One case of ventricular bradycardia with arrhythmia caused by teldane(特非那定致窦性心动过缓伴心律不齐1例)[J].Journal of Pharmaceutical Practice(中国临床药学杂志)1999;17(6):369. |
89. | [89]LI Zhen-ying(李振瑛)One case of atrio-ventricular fibrillation caused of oral teldane(口服特非那丁致心房纤颤1例)[J].Tian Jin Pharmacy(天津药学)1994;6(3):40-41. |
90. | [90]HAN Xiao-hong(韩晓虹),ZHANG hong(张弘).One case of severe heart toxicity casued by terfeandien(特非那丁致严重心脏毒性反应一例)[J].Chinese Journal of Dermatology(中华皮肤科杂志)1999;32(4):278-279. |
91. | [91]WANG Xiao-xia(王晓霞)One case of severe arryhthmia caused by tefernadine(阿司咪唑片中毒引起严重心律失常1例)[J].Journal of Clinical Cardiology(临床心血管病杂志)1997;13(1):11. |
92. | [92]XU Mei-hua(许美华),HOU Jia-ping(候加平).One case of completely right bundle branch block caused by teldane (特非那丁诱发完全性右束支传导阻滞1例)[J].J Clin Dermatol(临床皮肤病学杂志)1998;27(1):60. |
93. | [93]ZHAO Yong-qing(赵永清)One case of supraventricular tachycardia caused by loratadine(克敏能致室上性心动过速1例).Si Chuan Medicine(四川医学)2001;22(2):129. |
94. | [94]SUN Yu(孙宇),DIAO Shu-ling(刁树玲)、WANG Wen-ying (王文英).One case of torsade de pointes caused by tefernadine(特非那定致尖端扭转性室性心动过速一例).Chinese Journal of CardiacArrhythmias(中华心律失常学杂志)2001,2;5(1),43. |
95. | [95]LI Xiao-li(李肖莉).Two cases of severe arrhythmia caused by tefernadine(特非那丁致严重心律失常2例)[J].Journal of Heng Yang Medical College(衡阳医学院学报)2001;29(1):86. |
96. | [96]XIE Xiao-min(谢晓敏).Emergency nursing of patients withtorsade de pointes caused bytefernadine and Ketoconazole(1例特非那丁和酮康唑合用所致尖端扭转性室速的急救与护理)[J].HeilongjiangNursingJournal(黑龙江护理杂志)2000;6(10):30. |
97. | [97]LI Zhan-ping(李战平),HUANG Ai-hao(黄爱好)One case of ventriculartachycardia caused byteldane anditraconazole(里素劳与特非那丁合用致室性心动过速1例)[J]Chinese Journal of HospitalPharmacy(中国医院药学杂志)1998;18(10):478. |
98. | [98]CHENG Jing(陈静),ZHOU Mao-rong(周茂荣)One caseo of arrhythmia caused byteldane(特非那丁与红霉素合用致心律失常1例)[J].The Chinese Journal of Dermatovenereology(中国皮肤性病学杂志)1999;13(1):59. |
99. | [99]Abernethy DR, Barbey JT, Franc J, Brown KS, Feirrera I, Ford N,Salazar DE. Pharmacokinetics and drug disposition--loratadine: both antihistamines are associated with QTc prolongation[J]. Clinical Pharrmacilogy & Therapeutics.2001; 69(3): 96-103. |
100. | [100]Ahaj FJD, Rodriguez LAE Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs[J]. BLACKWELL SCIENCE LTD BR J-CLIN-PHAR 1999; 47:307-313. |
101. | [101]Kosoglo T, Lim JM, Batra VK, Cayen & Alfrime MB. Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole of cimetidine[J]. BR-J-CLIN-PHAR 2000; 50:581-589. |
102. | [102]Clifford CP, Adams DA, Murray S, Taylor GW, Wilkins MR, Boobis AR, Davies DS. The cardiac effects of tefernadine after inhibition of its metabolism by grapefruit juice[J]. J-CLIN-PHAR 1997; 52:311-315. |
103. | [103]Benton RE, Honig PK, Zamani K, Cantilena LR, Raymond L.Woosley. Grapefruit juice alters tefernadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardigram[J].Clinical Pharmacology & Therapeutics 1996; 59(4): 383-388. |
- 1. [1]Andrew’ s Diseases of the Skin[M]. 4 edition, 160.
- 2. [2]Bellanti JA; Wallerstedt DB. Allergic rhinitis update: Epidemiology and natural history[J]. Allergy-Asthma-Proc 2000; 21(6): 367-370.
- 3. [3]Stempel DA; Woolf R. The cost of treating allergic rhinitis[J]. CurrAllergy-Asthma-Rep. 2002; 2(3): 223-230.
- 4. [4]Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis[J]. J-Allergy-Clin-Immunol. 2001 Jul;108(1 Suppl): S2-S8.
- 5. [5]Monroe EW. Loratadine in the treatment of urticaria[J]. Clin-Ther 1997; 19(2): 232-242.
- 6. [6]Merk HF. Standard treatment: the role of antihistamines[J]. JInvestig-Dermatol-Symp-Proc 2001; 6(2): 153-156.
- 7. [7]Woosley RL. Cardiac actions of antihistamines[J]. Ann Rev Pharmacol Toxicol 1996;36:233-252.
- 8. [8]Lacerda AE, Roy ML, Lewis EW, Rampe D. Interaction of the nonsedating antihistmine loratadine with a Kv1.5-type potassium channel cloned from human heart[J]. Mol Pharmacol 1997; 52:314-322.
- 9. [9]Delpon E, Valenzuela C, Pilar G, Franqueza L, Snyders DJ, Tamargo J. Block of human cardiac Kv1.5 channels by loratadine: voltage-,time-, and use-dependant block at concentrations above therpeutic levels[J]. Cardiovasc Res 1997; 35: 341-350.
- 10. [10]Pratt CM, Hertz RP, Ellis BE, Crowell SP, Louv W, Moye L. Risk of developing life-threatening ventricular arrhythmia associated with terfenadine in comparison with over-the counter anithistaminess,inbuprofen and clematine[J]. Am J Cardiol 1994; 73: 346-352.
- 11. [11]Howarth PH, Holgate ST. Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever[J]. Thorax 1984; 39: 668-672;.
- 12. [12]Novembre E, Bernardini R, Marano EA, vergallo IG, Vierucci A.Comparative efficacy and tolerability of terfenadine versus astemizole in the treatment of seasonal allergic rhino-conjunctivitis in children[J]. Current Therapeutic Research 1990; 47 (5).
- 13. [13]Boland N. A double-blind study of astemizole and terfenadine in the treatment of perennial rtinitis[J]. Annals of Allergy 1988; 61.
- 14. [14]Girard JP, Sommacal-Schopf D, Bigliardi P, Henauer SA. Doubleblind comparison of astemizol, terfenadine and placebo in hay fever with special regard to onset of action[J]. J Int Med Res 1985; 13(102).
- 15. [15]Wood SF. Astemizole and terfenadine compared in hay fever[J]. The pratitioner 1986; 230.
- 16. [16]Oei HD. Double-blind comparison of loratadine (SCH29851),Astemizole, and placebo in hay fever with special regaid to onset of action[J]. Annals of Allergy 1988; 61.
- 17. [17]Lee STS, Amin MJ. Efficacy and safety of loratadine compared with astemizole in malaysion patients with allergic rhinitis[J]. Singapore MedJ 1994; 35:591-594.
- 18. [18]The LASAR Study Group. Double-blind comparison of the efficacy and safety of astemizole and loratadine in the treatment of seasonal allergic rhinitis[J]. Drug Invest. 1992; 4 (4):336-345.
- 19. [19]Muhaimeed HA1. Aparallel-group comparison of astemizole and loratadine for the treatment of perennial allergic rhinitis[J]. The Journal of International Medical Research 1997; 25: 175-181.
- 20. [20]Chervinsky P, Georgitis J, Banov C, Boggs P, Vande Stouwe R, and Greenstein S. Once daily loratadine versus astemizole once daily[J].Annals of Allergy 1994; 73.
- 21. [21]Harcup JW, Hawkes G, Saul PA, Dr Harcup JW .The efficacy and sedative profile of Astemizole and Cetirizine in the treatment of grass pollen hayfever in general practice. General Practitioner, The Surgery, Court Road, Malvern, Walvern, Worcs, WR14 3BL.
- 22. [22]Berkowitz RB, Dockhorn R, Lockey R, Findlay S, Howland WC,Mitchell DQ, Woehler T. Comparison of efficacy, safety, and skin test inhibition of cetirizine and astemizole[J]. Ann Allergy Asthma Immunol1996; 76: 363-368.
- 23. [23]Carpio JD, Kabbash L, Turenne Y, Prevost M, Hebert J, Bedard PM,Nedilsk MI, Gutkowski A, Schulz J. Efficacy and safety of loratadine (10 mg once daily), terfenadine (60 mg twice daily), and placebo in the treatment of seasonal allergic rhinitis[J]. J Allergy Clin Immunol 1989; 5 (84): 742-746.
- 24. [24]Horak F , Bruttmann G, Pedrali P, Weeke B, Frolund L, Wolff H,Christtophers E. A Multicentric Study of Loratadine, Terfenadine and Placebo in Patients with Seasonal Allergic Rhinitis.
- 25. [25]Gutkowski P, Bedard J, Carpio D, Hebert J, Prevost M, Schulz J,Turenne Y, Yeadon C. Comparison of the efficacy and safety of loratadine, terfenadine, and placeb in the treatment of seasonal allergic rhinitis[J]. JAllergy Clin Immuno 1998; 5(81): 902-907.
- 26. [26]Estelle F ,Simons R, Frcpc , Janice L, Lukowskl BN, Becker AB,Keith JS. Comparison of the effects of single doses of the new H1receptor antagonists loratadine and terfenddine versus placebo in children. Clinical and laboratory observations[J]. The Journal of Pediatrics 1991.
- 27. [27]Estelle F ,Simons R, Janice L, Lukowskl BN, Becker AB, Keith JS .Comparison of the effects of single doses the new H1-receptor antagonists loratadine and terfenadine versus placebo in childen[J].The Journal of Pediatrics 1991.
- 28. [28]Day JH, Briscoe M, Widlitzm MD, Cetirizine , loratadine, or placebo in subjects with seasonal allergic rhinitis: Effects after corrolled ragweed pollen challenge in an environmental ecposure unit[J]. J Allergy Clin Immunol 1998; 5 (101): 638-645.
- 29. [29]Persl L, Demoly P, Alan G, Bernard H, Francois T, Michel B,Bousquet J. Comparison between nasal provocation tests and skin tests in patients treated with lortadine and cetirizine[J]. J Allergy Clin Immunol 1999; 103: 591-594.
- 30. [30]Meltzer EO, Weiler JM, Widlitz MD. Comparative outdoor study of the efficacy, onset and duration of action, and safety of cetirizine,loratadine, and placebo for seasonal allergic rhinitis[J]. J Allergy Clin Immunol 1996; 97; 617-626.
- 31. [31]Chaweewan B, Jareonchai P ,Dhorranintra B. A Clinical Comparison of cetirizine versus astemizole in perennial allergic rhinitis[J]. Drug Invest. 1993; 5 (4); 222-228.
- 32. [32]Rijntjes E, Ghys L, Rihoux JR Astemizole and cetirizine in the treatment of seasonal allergic rhinitis: a comparative double-blind, multicentre study[J]. The Journal of International Medical Research 1990; 18:219-224.
- 33. [33]Lockey RF, Widlitz MD, Mitchell DQ, Lumry W, Dockhorn R,Woehler T, Grossman J. Comparative study of cetirizine and terfenadine versus placebo in the symptomatic management of seasonal allergic rhinitis[J]. Annals of Allergy, Asthma, & Immunology 1996;76: 448-454.
- 34. [34]Renton R, Fidler C, RosenbergR. Multicenter, crossover study of the efficacy and tolerability of terfenadine, 120 mg, versus cetirizine, 10mg, in perennial allergic rhinitis[J]. Annals of Allergy 1991; 67.
- 35. [35]Backhouse CI, Renton R, Fidler C, Rosenberg RM. Multicentre, double-blind comparison of terfenadine and cetirizine in patients with seasonal allergic rhinitis[J]. BJCP 1990; 44 (3).
- 36. [36]Andri G, Senna E, Betteli C, Givanni S, Andri G, Lombardi C,Mezzelani P. A comparison of the efficacy of cetirizine and terfenadine[J]. Allergy 1993; 48: 358-365.
- 37. [37]Bruuttmann G, Charpin D, Germouty J, Horak F, Grenoble GW.Evaluation of the efficacy and safety of loratadine in perennial allergic rhinitis[J]. JAllergy Clin Immunol 1989; 83:411-416.
- 38. [38]Macchia L, Maria FC, Paola RD, Michele GD, Bariletto G. Secondgeneration antihistamines in the treatment of seasonal allergic rhinitis due to parietaria and cypress pollen[J]. Pharmacological Research 2001; 1 44 (6).
- 39. [39]Harvet RP, Coner C, Sanders B, Westley R, Marsh W, Shapiro H,Phd, Wiener M, Pharmd. Model for outcomes assessment of antihistamine use for seasonal allergic rhinitis[J]. J Allergy Clin Immunol 1996; 97: 1233-1241.
- 40. [40]Day JH, Briscoe MP, Reginald HC, Ellis AK, Gervais P. Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis[J]. Ann Allergy Asthma Immunol 1997; 79:163-172.
- 41. [41]Ciprandi G, Pronzato C, Ricca V, Danzig P M, Canonica GW.Loratadine treatment of rhinitis due too pollen allergy reduces epithelial ICAM-1 espression[J]. Clinical and Experimental Allergy 1996;27: 1175-1183.
- 42. [42]Saviuc P, Danel V, Dixmerias F. Prolonged QT interval and Torsade de pointes following Astemizole overdose[J]. Clinical Toxicology 1993;31(1):121-125.
- 43. [43]Broadhurst P, Nathan AW. Cardiac arrest in a young woman with the long QT syndrome and concomitant astemizole ingestion[J]. BRHEART-J 1993; 70: 469-470.
- 44. [44]Sakemi H, VanNatta B, Beach L. Torsade de points induced by astemizole in a patient with prolongation of the QT interval.American HeartJounal 1993 May; 125(5): 1436-1438.
- 45. [45]Clark A, Love H. Astemizole-induced ventricular arrhythmias: an unexpected cause of convulsions[J]. Intetnal Journal of Cardiology 1991; 33: 164-165.
- 46. [46]Tobin JR, Doyle TP, Ackerman AD, Brenner JI. Astemizole-induced cardiac conduction disturbances in a child[J]. JAMA 1991; 266(19):2737-2740.
- 47. [47]ZHOU YU-lang(周于浪),ZOU Qin(邹勤).1 case severe allergy caused by astemizole(息斯敏致严重过敏1例)[J].The InternedicateMedicalJournal(中级医刊)1995;30(4):59.
- 48. [48]TAI Chang-yun(太昌允),JIN En-shi(金恩实).One case of one-degree atrioventricular block with bradycardia caused by astemizole(阿司咪唑致Ⅰ度房室传导阻滞伴严重心动过缓1例)[J]ChineseJournal of New Drugs(中国新药杂志)1995;4(1):49.
- 49. [49]ZHAO Hui-ping(赵惠平)One case of hematuria caused by astemizole(阿司咪唑致血尿1例)[J].YAOWU LIUXINGBINGXUEZAZHI(药物流行病学杂志)1994;3(3):169.
- 50. [50]TIAN Ren-fa(田仁发)One case of allergic shock by astemizole (阿司咪唑致过敏性休克1例)[J].Chinese Journal of Hospital pharmacy(中国医院药学杂志)1995;15(1):522.
- 51. [51]WANG Chun-ming(王春明),WEI Tie-ming(韦铁民).One case of QTc prolongation and tosade de pointes caused by astemizole (阿司咪唑致QT间期延长伴尖端扭转型室性心动过速一例)[J].Chinese Journal of Cardiac Pacing and Electrophysiology (中国心脏起博与心电生理杂志)2000;14(4):249.
- 52. [52]XU Cheng-wen (徐成文) . One successful salvage of cardiac arrest caused by astemizole intoxication(阿司咪唑中毒致心跳骤停抢救成功1例)[J].Chinese Journal of Hospitalpharmacy(中国医院药学杂志)1995;15(10):476477.
- 53. [53]YIN Li-xin(殷立新),ZHAOZhi(赵智),KANGZe-kun(亢泽h ) .52 case series of adverse drug reactions by astemizole ( 阿司咪唑不良反应52例分析)[J].China Pharmacist(中国药师)2000;3(6):358-359.
- 54. [54]YANG Hua (杨华) . One case of torsade de pointes caused by overdose Hi smanal(息斯敏中毒致尖端机转型室速一例)[J].Medical Research Proceedings(医学研究通讯)1996;25(4):31-32.
- 55. [55]CHI Jun-ling(迟军玲),YI Zhong-zhi(仪忠直),ZHANG Rui ( 张蕊 ) . One case of epilepsy like episode caused by overdos of hismanl(息斯敏过量致癫痫样发作1例报告)[J].Journal of Clinical Neurological Electrophysiology(临床神经电生理学杂志)2001 ,2; 10( 1 ).
- 56. [56]ZHENG Hou-lin (郑厚林),LU Xiao-feng(鲁小峰),WAN Bin(万斌)One case of allergic shock caused by astemizole(阿司咪唑致过敏性休克1例)[J].Ning Bo Medicine(宁波医学)1 999;9(4).
- 57. [57]PAN Ming-kang(潘明康)One case oftorsade de pointes cuased bylarge dose astemizole(大剂量阿司咪唑诱发尖端扭转型室性心动过速1例)[J].Tie Dao Medicine(铁道医学)1996 10;24(5).
- 58. [58]GAO Xiang(高翔),LIU Hong-qin(刘鸿琴),ZHAO Li一mei (肇丽梅)One case of allergie shock by astemizole(阿司咪唑引起过敏性休克1例)[J].YAOWULIUXINGBINGXUEZAZHI(药物流行病学杂志)1996;5(3).
- 59. [59]GU Ai-ming(顾爱明)Astemizoleinduced QTc prolongation.two cases(阿司咪唑致心电图Q-T间期延长一附2例报告)[J].Journal of Clinical Dermatology(临床皮肤科杂志)1998;27(4).
- 60. [60]YANG Chuan Ying(杨传英),Duan Zhi-rong(段志荣).One case of angina pectoris caused by astemizole(阿司咪唑诱发心绞痛1例)[J].CapitalMedicine(技术交流学术研究)1998;5(11):36.
- 61. [61]Wang Yong(王勇),WANG Hong-Lin(王洪林),DU Ling-yun (杜凌云).Severe low potassium syndrome caused by astemizole (阿司咪唑致严重低钾血症1例)[J].Chinese Journal of New Drug and Clinical Medicines(中国新药与临床杂志)1999;18(1):63.
- 62. [62]ZHANG Yuan(张媛),FU Xia(付霞),WANG Rui-ru(王瑞儒),ZHAO Ming-wu(赵鸣武)Two cases of torsade de pointes by astemizole(阿司咪唑致尖端扭转性室性心动过速二例)[J].Chinese Journal of Internal Medicine(中华内科杂志)1995;34(7):484-485.
- 63. [63]Goss JE, Ramo BW, Albuquerque BK. Torsades de points associated with Astemixole (hismanal) therapy[J]. ARCH-INTERN-MED 1993.13:153.
- 64. [64]LIU Guang-hui(刘光辉)One case oftorsade de pointes caused by overdose of hismanal(息斯敏中毒致扭转型室速1例报告)[J].Journal of Xi’an Medical College(西安医科大学学报).17:162.
- 65. [65]ZONG Wei-zhen(宗卫珍)One case of supraventriculartachycardia caused by hismanal(息斯敏致室上性心动过速1例)[J].Journal ofClinical Dermatology(临床皮肤科杂志)1997;5:343.
- 66. [66]SONG Wei-zhen(宋卫珍)Supraventricular tachycardia caused by hismanal(息斯敏致室上性心动过速1例)[J].Chinese J Derm Venereol(中国皮肤性病学杂志)1999;13(2):120.
- 67. [67]WU Fang-ping(吴芳萍),ZHOU Ling(周玲).LI Shi-yin(李世滢).One case of epilepsylike episode caused by overdosof hismanal(息斯敏过量致癫痫样发作1例报告)[J].Journal of Clinical Elctroencephaloly(临床脑电学杂志)2000;9(4):224.
- 68. [68]TANG Yan-hong(唐艳红)One case of torsade de pointes caused by overdose of hismanal(息斯敏药物中毒致尖端扭转型室速一例报告)[J].Chinese Medicine of Factory and Mine(中国厂矿医学)1996;4:285.
- 69. [69]TIAN Ji-xian(国继先)LIE Deng-shan(雷登山),ZHANG Jiajie(张家界).One case of torsade de pointes caused by Hismanal (息斯敏中毒致尖端扭转型室速1例)[J].Journal of Internal Intensive Medicine(内科急危重症杂志)4;(4):183.
- 70. [70]Sintonen SP, Vitasalo M, Toivonen L, Neuvonen P. Itraconazole prevents tefernadine metabolism and increases risk of torsades de pointes ventricular tachycardia[J]. BMJ-CLIN-PHARMACOL 1993;45: 191-193.
- 71. [71]Feroze H, Suri R, Siverman DI. Torsades de points from tefernadine and sotalol given in combination[J]. PACE 1996; 19:1519-1521.
- 72. [72]Koh K K, Faca F, Rim MS, Yoon J, Kim S S. Torsade de pointes induced by tefernadine in a patient with long QT syndrome[J].Journal of Electrocardiology 1994; 27(4): 343-346.
- 73. [73]Crane J K, Shih HT. Syncope and cardiac arrhythmia due to an interaction between itraconazole and tefernadine[J]. The American Journal of Medicine 1993; 95: 445-446.
- 74. [74]Kamisako T, Adachi Y, Nkagawa H, Yamamoto T.Torsades de pointes associated with tefernadine in a case of liver cirrhosis and hepatocellular carcinoma[J]. INTERNAL MEDICINE 1995; 34(2):92-95.
- 75. [75]Peter K.Honig, D C. Hull W R, Zamani K, Smith J E., Cantilena L R.. Itraconazole affects single-dosa tefernadine pharmacokinetics and cardiac repolarization pharmacodynamics[J]. J-CLIN-PHAR 1993;33: 1201-1206.
- 76. [76]June RA, Nasr I.Torsades de pointes with tefernadine ingestion.
- 77. [77]ZHANG Feng-ru(张凤如),SHEN Wei-feng(沈卫峰)One case oftorsade de pointes caused bytefernadine(特非那丁引起扭转型室速1例)[J].Jounal of Clinical Electrocardiology(临床心脏电生理学杂志)1995;4(3):120.
- 78. [78]ZHANG S u-ping(章素萍)Repeated syncopal episodes withtorsade de poonted caused by astemziole,case report(阿司咪唑中毒致尖端扭转型室速反复发作性晕厥1例)[J].Chinese Journal of New Drugs(中国新药杂志)1996;5(3):215.
- 79. [79]XU Cheng-wen(徐成文)One case of successful salvage of car diac arrest caused by hismanal mtoxicaton(息斯敏中毒心跳骤停抢救成功1例)[J].Jiang Su Medicine(江苏医药)1995;2(10):672.
- 80. [80]XU Xing-shu(徐性述),WANG Xiao-ping(王晓萍)one caseof allergic shock caused by hismanal(抢救息斯敏致过敏性休克一例)[J].Chinese Journal of Pediatrics(中华儿科杂志)1995;33(6):383.
- 81. [81]WANGXin-yi(汪新义)Two cases of severe headache byteferna-dine(特非那丁引起剧烈头痛2例)[J].The Chinese Journal ofDermatovenereology(中国皮肤性病学杂志)1995;9(3):186.
- 82. [82]DU Xiu-ying(杜秀英),DUAN Shu-lan(段淑兰)One case of allergic shock caused by hismanal(息斯敏致过敏性休克一例报告)[J].MedicalJournal of Qinghai(青海医药杂志)1996;161:8.
- 83. [83]XIANG Chun-Tao(向春桃)One case of epilepsy-like episode caused by oral hismanal(口服息斯敏引起癫痫样发作1例)[J].Medical Theoryand Practice(医学理论与实践)1998;11(2):562.
- 84. [84]HUANG Jian-ming(黄建明)Two cases of Paroxysmal ventriculartachycardia caused by teldane(特非那定致阵发性心动过速2例报告).NewMedicine(新医学)1999;30(3):145.
- 85. [85]LIU Zhao-ying(刘兆英),LUO Yan-hong(罗延宏),WANG Ying-zhong(王应忠)One case of Torsade de pointes(特非那丁致扭转性心动过速1例)[J].JournalofClinical Cardiology(China)(临床心脏病学杂志)1999;1 5(1):20.
- 86. [86]CHEN Lian-zhen(陈莲珍)Death case caused by combinationof terfeandine and grapefruitjuice(特非那定与葡萄水果汁相互作用致死1例)[J].Chinese Journal of Clinical Pharmacy(中国临床药学杂志) 1999;8(1):42.
- 87. [87]HUANG Wen-hui(黄文辉),ZHAN Xue-bing(詹学斌).One case of torsade de pointes caused by terfeandine(特非那丁诱发尖端扭转型室速1例)[J].ZHE JIANG ZHONG XI YI JIE HE ZA ZHI(浙江中西医结合杂志)1999;9(4):272.
- 88. [88]WANYu-ming(万雨明),LI Ming(李明)One case of ventricular bradycardia with arrhythmia caused by teldane(特非那定致窦性心动过缓伴心律不齐1例)[J].Journal of Pharmaceutical Practice(中国临床药学杂志)1999;17(6):369.
- 89. [89]LI Zhen-ying(李振瑛)One case of atrio-ventricular fibrillation caused of oral teldane(口服特非那丁致心房纤颤1例)[J].Tian Jin Pharmacy(天津药学)1994;6(3):40-41.
- 90. [90]HAN Xiao-hong(韩晓虹),ZHANG hong(张弘).One case of severe heart toxicity casued by terfeandien(特非那丁致严重心脏毒性反应一例)[J].Chinese Journal of Dermatology(中华皮肤科杂志)1999;32(4):278-279.
- 91. [91]WANG Xiao-xia(王晓霞)One case of severe arryhthmia caused by tefernadine(阿司咪唑片中毒引起严重心律失常1例)[J].Journal of Clinical Cardiology(临床心血管病杂志)1997;13(1):11.
- 92. [92]XU Mei-hua(许美华),HOU Jia-ping(候加平).One case of completely right bundle branch block caused by teldane (特非那丁诱发完全性右束支传导阻滞1例)[J].J Clin Dermatol(临床皮肤病学杂志)1998;27(1):60.
- 93. [93]ZHAO Yong-qing(赵永清)One case of supraventricular tachycardia caused by loratadine(克敏能致室上性心动过速1例).Si Chuan Medicine(四川医学)2001;22(2):129.
- 94. [94]SUN Yu(孙宇),DIAO Shu-ling(刁树玲)、WANG Wen-ying (王文英).One case of torsade de pointes caused by tefernadine(特非那定致尖端扭转性室性心动过速一例).Chinese Journal of CardiacArrhythmias(中华心律失常学杂志)2001,2;5(1),43.
- 95. [95]LI Xiao-li(李肖莉).Two cases of severe arrhythmia caused by tefernadine(特非那丁致严重心律失常2例)[J].Journal of Heng Yang Medical College(衡阳医学院学报)2001;29(1):86.
- 96. [96]XIE Xiao-min(谢晓敏).Emergency nursing of patients withtorsade de pointes caused bytefernadine and Ketoconazole(1例特非那丁和酮康唑合用所致尖端扭转性室速的急救与护理)[J].HeilongjiangNursingJournal(黑龙江护理杂志)2000;6(10):30.
- 97. [97]LI Zhan-ping(李战平),HUANG Ai-hao(黄爱好)One case of ventriculartachycardia caused byteldane anditraconazole(里素劳与特非那丁合用致室性心动过速1例)[J]Chinese Journal of HospitalPharmacy(中国医院药学杂志)1998;18(10):478.
- 98. [98]CHENG Jing(陈静),ZHOU Mao-rong(周茂荣)One caseo of arrhythmia caused byteldane(特非那丁与红霉素合用致心律失常1例)[J].The Chinese Journal of Dermatovenereology(中国皮肤性病学杂志)1999;13(1):59.
- 99. [99]Abernethy DR, Barbey JT, Franc J, Brown KS, Feirrera I, Ford N,Salazar DE. Pharmacokinetics and drug disposition--loratadine: both antihistamines are associated with QTc prolongation[J]. Clinical Pharrmacilogy & Therapeutics.2001; 69(3): 96-103.
- 100. [100]Ahaj FJD, Rodriguez LAE Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs[J]. BLACKWELL SCIENCE LTD BR J-CLIN-PHAR 1999; 47:307-313.
- 101. [101]Kosoglo T, Lim JM, Batra VK, Cayen & Alfrime MB. Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole of cimetidine[J]. BR-J-CLIN-PHAR 2000; 50:581-589.
- 102. [102]Clifford CP, Adams DA, Murray S, Taylor GW, Wilkins MR, Boobis AR, Davies DS. The cardiac effects of tefernadine after inhibition of its metabolism by grapefruit juice[J]. J-CLIN-PHAR 1997; 52:311-315.
- 103. [103]Benton RE, Honig PK, Zamani K, Cantilena LR, Raymond L.Woosley. Grapefruit juice alters tefernadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardigram[J].Clinical Pharmacology & Therapeutics 1996; 59(4): 383-388.