蜂毒主动免疫对预防蜂蜇伤严重毒效应的研究进展_West China Medical Journal

Authors：

刘鹏 , 倪芬 , 许树云 ,  曹钰

Corresponding author：

曹钰, Email: ttdd7441@163.com

Keywords：

蜂蜇伤; 速发型过敏反应; 蜂毒液主动免疫; 疗效

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蜂蜇伤属于常见动物致伤病，伤后轻者可出现局部红肿热痛，部分患者中毒症状明显，甚至因感染或多脏器功能不全而死亡。目前国内对蜂蜇伤的治疗基本局限于对症治疗和支持治疗，很少采取主动免疫方式防患于未然。蜂毒液主动免疫即是将少量蜂毒提取液对高危人群进行注射，以使其获得主动免疫的方法，效果确切，安全性高，已成为国外防治蜂蜇伤严重中毒反应的最主要方法。现就蜂毒液主动免疫的应用机制、安全性、应用范围、使用方法等作一阐述。

Citation： 刘鹏,倪芬,许树云,曹钰. 蜂毒主动免疫对预防蜂蜇伤严重毒效应的研究进展. West China Medical Journal, 2012, 27(10): 1575-1577. doi: Copy

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6.	Roy M, Chatterjee M, Deb S, et al. Encephalitis following wasp sting[J]. Indian J Pediatr, 2010, 77(10): 1193-1194.
7.	Mondal N, Krishnamurthy S, Narayanan P, et al. Bilateral Ptosis in a child following massive attack by a swarm of wasps[J]. J Child Neurol, 2011, 26(10): 1322-1324.
8.	邹翎, 李峥艳, 孙家瑜, 等. 磁共振成像在蜂蜇伤致横纹肌溶解诊断中的应用[J].华西医学, 2010, 25(5): 898-900.
9.	陈懿, 秦敏, 洪芸. 连续性血液净化治疗蜂蜇伤致急性肾功能衰竭的临床观察与护理体会[J]. 华西医学, 2009, 24(6): 1526-1564.
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12.	Hamilton RG. Diagnosis and treatment of allergy to hymenoptera venoms[J]. Curr Opin Allergy Clin Immunol, 2010, 10(4): 323-329.
13.	Sabatos-Peyton CA, Verhagen J, Wraith DC. Antigen-specific immunotherapy of autoimmune and allergic diseases[J]. Curr Opin Immunol, 2010, 22(5): 609-615.
14.	Brathwaite N, du Toit G, Lloydhope K, Sinnott L, et al. The RCPCH care pathway for children with venom allergies: an evidence and consensus based national approach[J]. Arch Dis Child, 2011, 96(Suppl 2): 38-40.
15.	何韶衡, 刘志刚. 基础过敏反应学[M].北京: 科学出版社, 2009: 877-878.
16.	Jackola DR, Pierson-Mullany LK, Liebeler CL, et al. Variable binding affinities for allergen suggest a ‘selective competition’ among immunoglobulins in atopic and non-atopic humans[J]. Mol Immunol, 2002, 39(5-6): 367-377.
17.	Pierson-Mullany LK, Jackola D, Blumenthal M, et al. Altered allergen binding capacities of Amb 1- specific IgE and IgG4 from ragweed-sensitive patiens receiving immunotherapy[J]. Ann Alergy Asthma Immunol, 2000, 84(2): 241-243.
18.	Freeman TM.. Clinical practice. Hypersensitivity to hymenoptera stings[J]. N Engl J Med, 2004, 351(19): 1978-1984.
19.	Roll A, Hofbauer G, Ballmer-Weber BK, et al. Safety of specific immunotherapy using a four-hour ultra-rush induction scheme in bee and wasp allergy [J]. J Investig Allergol Immunol, 2006, 16(2): 79-85.
20.	Goldberg A, Conﬁno-Cohen R. Bee venom immunotherapy—how early is it effective?[J]. Allergy, 2010, 65(3): 391-395 .
21.	Golden DB, Kelly D, Hamilton RG, et al. Venom immunotherapy reduces large local reactions to insect stings[J]. J Allergy Clin Immunol, 2009, 123(6): 1371-1375.

1. 　Bilò BM, Bonifazi F. Epidemiology of insect – venomanaphylaxis[J]. Curr Opin Allergy Clin Immunol, 2008, 8(4): 330-337.
2. 　Przybilla B, Ruëff F. Desensitization of allergy to hymenoptera venoms[J]. Wien Med Wochenschr, 1999, 149(14-15): 421-428.
3. 　Golden D. Stinging insect allergy[J]. Am Fam Physician, 2003, 67 (12): 2541-2546.
4. 　Prado M, Quirós D, Lomonte B. Mortality due to hymenoptera stings in Costa Rica, 1985-2006[J]. Rev Panam Salud Publica, 2009, 25(5): 389-393.
5. 　Blacklow B, Escoubas P, Nicholson GM. Characterisation of theheterotrimeric presynaptic hospholipaseA(2) neurotoxin complex from the venom of the common death adder (Acanthophis antarcticus) [J]. Biochem Pharmacol, 2010, 80(2): 277-287.
6. 　Roy M, Chatterjee M, Deb S, et al. Encephalitis following wasp sting[J]. Indian J Pediatr, 2010, 77(10): 1193-1194.
7. 　Mondal N, Krishnamurthy S, Narayanan P, et al. Bilateral Ptosis in a child following massive attack by a swarm of wasps[J]. J Child Neurol, 2011, 26(10): 1322-1324.
8. 　邹翎, 李峥艳, 孙家瑜, 等. 磁共振成像在蜂蜇伤致横纹肌溶解诊断中的应用[J].华西医学, 2010, 25(5): 898-900.
9. 　陈懿, 秦敏, 洪芸. 连续性血液净化治疗蜂蜇伤致急性肾功能衰竭的临床观察与护理体会[J]. 华西医学, 2009, 24(6): 1526-1564.
10. 　Rebecca S, Gruchalla. Immunotherapy in allergy to insect stings in children[J]. N Engl J Med, 2004, 351(7): 707-709.
11. 　Celikel S, Karakaya G, Yurtsever N, et al. Bee and bee products allergy in Turkish beekeepers: determination of risk factors for systemic reactions[J]. Allergol Immunopathol (Madr), 2006, 34(5): 180-184.
12. 　Hamilton RG. Diagnosis and treatment of allergy to hymenoptera venoms[J]. Curr Opin Allergy Clin Immunol, 2010, 10(4): 323-329.
13. 　Sabatos-Peyton CA, Verhagen J, Wraith DC. Antigen-specific immunotherapy of autoimmune and allergic diseases[J]. Curr Opin Immunol, 2010, 22(5): 609-615.
14. 　Brathwaite N, du Toit G, Lloydhope K, Sinnott L, et al. The RCPCH care pathway for children with venom allergies: an evidence and consensus based national approach[J]. Arch Dis Child, 2011, 96(Suppl 2): 38-40.
15. 　何韶衡, 刘志刚. 基础过敏反应学[M].北京: 科学出版社, 2009: 877-878.
16. 　Jackola DR, Pierson-Mullany LK, Liebeler CL, et al. Variable binding affinities for allergen suggest a ‘selective competition’ among immunoglobulins in atopic and non-atopic humans[J]. Mol Immunol, 2002, 39(5-6): 367-377.
17. 　Pierson-Mullany LK, Jackola D, Blumenthal M, et al. Altered allergen binding capacities of Amb 1- specific IgE and IgG4 from ragweed-sensitive patiens receiving immunotherapy[J]. Ann Alergy Asthma Immunol, 2000, 84(2): 241-243.
18. 　Freeman TM.. Clinical practice. Hypersensitivity to hymenoptera stings[J]. N Engl J Med, 2004, 351(19): 1978-1984.
19. 　Roll A, Hofbauer G, Ballmer-Weber BK, et al. Safety of specific immunotherapy using a four-hour ultra-rush induction scheme in bee and wasp allergy [J]. J Investig Allergol Immunol, 2006, 16(2): 79-85.
20. 　Goldberg A, Conﬁno-Cohen R. Bee venom immunotherapy—how early is it effective?[J]. Allergy, 2010, 65(3): 391-395 .
21. 　Golden DB, Kelly D, Hamilton RG, et al. Venom immunotherapy reduces large local reactions to insect stings[J]. J Allergy Clin Immunol, 2009, 123(6): 1371-1375.

West China Medical Journal

蜂毒主动免疫对预防蜂蜇伤严重毒效应的研究进展

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