窄波成像在膀胱癌早期诊断中的应用进展_West China Medical Journal

Authors：

何宗海 ¹ ,  卢一平 ²

Corresponding author：

卢一平, Email: he.yao.2008@163.com

Keywords：

膀胱癌; 窄波成像; 膀胱镜; 研究进展

Video：

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膀胱癌是泌尿系统最常见的恶性肿瘤、具有多发、易复发、复发后恶性程度提高等特点。虽然膀胱镜检查仍然是早期诊断膀胱癌的主要手段，但是目前常用的普通膀胱镜不易发现膀胱黏膜的细微病变，可能导致漏诊或手术治疗不彻底。窄波成像（NBI）是21世纪初新研发的全新诊断技术，其能够显著增强膀胱镜检查的对比度和清晰度，能够更加清楚地显示黏膜表层的毛细血管和腺管开口，不仅可以提高膀胱癌的早期诊断水平，还可以有效地为经尿道膀胱肿瘤电切术手术提供指导。尽管对NBI应用的远期效果以及能否减少膀胱癌患者术后膀胱灌注和膀胱镜检查的次数还有待进一步研究和观察，但是NBI技术所具有的独特优势为膀胱癌的早期诊断和治疗提供了新的契机。

Citation： 何宗海,卢一平. 窄波成像在膀胱癌早期诊断中的应用进展. West China Medical Journal, 2012, 27(10): 1575-1581. doi: Copy

1.	顾方六. 尿路上皮肿瘤的诊断和治疗[M]∥吴阶平. 吴阶平泌尿外科学. 济南: 山东科学技术出版社, 2004: 965-966.
2.	虞颂庭, 臧美孚, 夏湣. 尿路上皮肿瘤概论[M]//吴阶平. 吴阶平泌尿外科学. 济南: 山东科学技术出版社, 2004: 919-942.
3.	Messing EM. Urothelial tumors of the urinary tract[M]//Wash PC, Retik AB, Vaughan ED Jr, et al. Capbell’s urology. 8th ed. Philadelphia (PA): W.B. Saunders, 2002: 2732-2784.
4.	van der Meijden AP, Sylvester R, Oosterlinck W, et al. EAU guidelines on the diagnosis and treatment of urothelial carcinoma in situ[J]. Eur Urol, 2005, 48(3): 363-371.
5.	Lamm DL. Carcinoma in situ[J]. Urol Clin North Am, 1992, 19(3): 499-508.
6.	俞天麟, 金锡御. 手术学全集: 泌尿外科卷[M]. 北京: 人民军医出版社, 1994: 306-307.
7.	Brausi M, Collette L, Kurth K, et al. Variability in the recurrence rate at first follow-up cystoscopy after TUR in stage Ta T1 transitional cell carcinoma of the bladder: a combined analysis of seven EORTC studies[J]. Eur Urol, 2002, 41(5): 523-531.
8.	廖勇, 阎洪涛, 王东, 等. 膀胱移行细胞癌中微血管密度检测的临床意义[J]. 现代泌尿外科杂志, 2006, 11(2): 81-82.
9.	Volm M, Koomagi R, Kaufmann M, et al. Microvessel density, expression of proto-oncogenes, resistance-related proteins and incidence of metastases in primary ovarian carcinomas[J]. Clin Exp Metastasis, 1996, 14(3): 209-214.
10.	Hollingeworth HC, Kohn EC, Steinberg SM, et al. Tumor angiogenesis in advanced stage ovarian carcinoma[J]. Am J Pathol, 1996, 147(1): 33-35.
11.	付娅, 郭梅梅, 贺克俭. 窄带成像内镜的原理及临床应用现状[J]. 医学综述, 2009, 15(5): 754-758.
12.	Loidl W, Schmidbauer J, Susani M, et al. Flexible cystoscopy assisted by hexaminolevulinate induced fluorescence: a new approach for bladder Cancer detection and surveillance?[J]. Eur Urol, 2005, 47(3): 323-326.
13.	Tatsugami K, Kuroiwa K, Kamoto T, et al. Evaluation of narrow-band imaging as a complementary method for the detection of bladder cancer[J]. J Endourol, 2010, 24(11): 1807-1811.
14.	Carlo I, Francesco G. NBI improves the detection rate of bladder cancer and leaves the bladder more receptive to the BCG topic treatment[J]. J Endourol, 2011, 25(Suppl 1): A130-A131.
15.	Cauberg EC, Kloen S, Visser M, et al. Narrow band imaging cystoscopy improves the detection of non-muscle-invasive bladder cancer[J]. Urology, 2010, 76(3): 658-663.
16.	陈光富, 王保军, 马鑫, 等. NBI技术结合电子软膀胱镜在膀胱肿瘤早期诊断中的应用研究[J]. 临床泌尿外科杂志, 2009, 24(8): 603-605.
17.	宋晓东, 叶章群, 包世新, 等. 窄带光成像在膀胱癌早期诊断及复发监测中的应用研究[J]. 现代泌尿生殖肿瘤杂志, 2009, 1(6): 325-327.
18.	Bryan RT, Billingham LJ, Wallace DM. Narrow-band imaging flexible cystoscopy in the detection of recurrent urothelial cancer of the bladder[J]. BJU Int, 2008, 101(6): 702-705.
19.	Naselli A, Introini C, Bertolotto F, et al. Narrow band imaging for detecting residual/recurrent cancerous tissue during second transurethral resection of newly diagnosed non-muscle-invasive high-grade bladder Cancer[J]. BJU Int, 2010, 105(2): 208-211.
20.	Herr HW, Donat SM. Reduced bladder tumour recurrence rate associated with narrow-band imaging surveillance cystoscopy[J]. BJU Int, 2011, 107(3): 396-398.
21.	张大宏, 张琦, 刘峰. 窄光成像膀胱镜在膀胱肿瘤诊断中的应用[J]. 中华泌尿外科杂志, 2010, 31(3): 182-184.
22.	那彦群. 中国泌尿外科疾病诊断治疗指南手册（2011版）[M]. 北京: 人民卫生出版社, 2011: 25-26.
23.	Grossman HB, Gomella L, Fradet Y, et al. A phase III, multicenter comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of superficial papillary lesions in patients with bladder Cancer[J]. J Urol, 2007, 178(1): 62-67.
24.	Machida H, Sano Y, Hamamoto Y, et al. Narrow-band imaging in the diagnosis of colorectal mucosal lesions: a pilot study[J]. Endoscopy, 2004, 36(12): 1094-1098.
25.	Ren H, Park KC, Pan R, et al. Early detection of carcinoma in situ of the bladder: a comparative study of white light cystoscopy, narrow band imaging, 5-ALA fluorescence cystoscopy and 3-dimensional optical coherence tomography[J]. J Urol, 2012, 187(3): 1063-1070.
26.	沈益君, 朱一平, 叶定伟, 等. 窄波成像电子膀胱软镜在膀胱肿瘤诊断中的应用价值[J]. 中华泌尿外科杂志, 2010, 31(6): 383-385.
27.	Herr H, Donat M, Dalbagni G, et al. Narrow-band imaging cystoscopy to evaluate bladder tumours--individual surgeon variability[J]. BJU Int, 2010, 106(1): 53-55.

1. 　顾方六. 尿路上皮肿瘤的诊断和治疗[M]∥吴阶平. 吴阶平泌尿外科学. 济南: 山东科学技术出版社, 2004: 965-966.
2. 　虞颂庭, 臧美孚, 夏湣. 尿路上皮肿瘤概论[M]//吴阶平. 吴阶平泌尿外科学. 济南: 山东科学技术出版社, 2004: 919-942.
3. 　Messing EM. Urothelial tumors of the urinary tract[M]//Wash PC, Retik AB, Vaughan ED Jr, et al. Capbell’s urology. 8th ed. Philadelphia (PA): W.B. Saunders, 2002: 2732-2784.
4. 　van der Meijden AP, Sylvester R, Oosterlinck W, et al. EAU guidelines on the diagnosis and treatment of urothelial carcinoma in situ[J]. Eur Urol, 2005, 48(3): 363-371.
5. 　Lamm DL. Carcinoma in situ[J]. Urol Clin North Am, 1992, 19(3): 499-508.
6. 　俞天麟, 金锡御. 手术学全集: 泌尿外科卷[M]. 北京: 人民军医出版社, 1994: 306-307.
7. 　Brausi M, Collette L, Kurth K, et al. Variability in the recurrence rate at first follow-up cystoscopy after TUR in stage Ta T1 transitional cell carcinoma of the bladder: a combined analysis of seven EORTC studies[J]. Eur Urol, 2002, 41(5): 523-531.
8. 　廖勇, 阎洪涛, 王东, 等. 膀胱移行细胞癌中微血管密度检测的临床意义[J]. 现代泌尿外科杂志, 2006, 11(2): 81-82.
9. 　Volm M, Koomagi R, Kaufmann M, et al. Microvessel density, expression of proto-oncogenes, resistance-related proteins and incidence of metastases in primary ovarian carcinomas[J]. Clin Exp Metastasis, 1996, 14(3): 209-214.
10. 　Hollingeworth HC, Kohn EC, Steinberg SM, et al. Tumor angiogenesis in advanced stage ovarian carcinoma[J]. Am J Pathol, 1996, 147(1): 33-35.
11. 　付娅, 郭梅梅, 贺克俭. 窄带成像内镜的原理及临床应用现状[J]. 医学综述, 2009, 15(5): 754-758.
12. 　Loidl W, Schmidbauer J, Susani M, et al. Flexible cystoscopy assisted by hexaminolevulinate induced fluorescence: a new approach for bladder Cancer detection and surveillance?[J]. Eur Urol, 2005, 47(3): 323-326.
13. 　Tatsugami K, Kuroiwa K, Kamoto T, et al. Evaluation of narrow-band imaging as a complementary method for the detection of bladder cancer[J]. J Endourol, 2010, 24(11): 1807-1811.
14. 　Carlo I, Francesco G. NBI improves the detection rate of bladder cancer and leaves the bladder more receptive to the BCG topic treatment[J]. J Endourol, 2011, 25(Suppl 1): A130-A131.
15. 　Cauberg EC, Kloen S, Visser M, et al. Narrow band imaging cystoscopy improves the detection of non-muscle-invasive bladder cancer[J]. Urology, 2010, 76(3): 658-663.
16. 　陈光富, 王保军, 马鑫, 等. NBI技术结合电子软膀胱镜在膀胱肿瘤早期诊断中的应用研究[J]. 临床泌尿外科杂志, 2009, 24(8): 603-605.
17. 　宋晓东, 叶章群, 包世新, 等. 窄带光成像在膀胱癌早期诊断及复发监测中的应用研究[J]. 现代泌尿生殖肿瘤杂志, 2009, 1(6): 325-327.
18. 　Bryan RT, Billingham LJ, Wallace DM. Narrow-band imaging flexible cystoscopy in the detection of recurrent urothelial cancer of the bladder[J]. BJU Int, 2008, 101(6): 702-705.
19. 　Naselli A, Introini C, Bertolotto F, et al. Narrow band imaging for detecting residual/recurrent cancerous tissue during second transurethral resection of newly diagnosed non-muscle-invasive high-grade bladder Cancer[J]. BJU Int, 2010, 105(2): 208-211.
20. 　Herr HW, Donat SM. Reduced bladder tumour recurrence rate associated with narrow-band imaging surveillance cystoscopy[J]. BJU Int, 2011, 107(3): 396-398.
21. 　张大宏, 张琦, 刘峰. 窄光成像膀胱镜在膀胱肿瘤诊断中的应用[J]. 中华泌尿外科杂志, 2010, 31(3): 182-184.
22. 　那彦群. 中国泌尿外科疾病诊断治疗指南手册（2011版）[M]. 北京: 人民卫生出版社, 2011: 25-26.
23. 　Grossman HB, Gomella L, Fradet Y, et al. A phase III, multicenter comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of superficial papillary lesions in patients with bladder Cancer[J]. J Urol, 2007, 178(1): 62-67.
24. 　Machida H, Sano Y, Hamamoto Y, et al. Narrow-band imaging in the diagnosis of colorectal mucosal lesions: a pilot study[J]. Endoscopy, 2004, 36(12): 1094-1098.
25. 　Ren H, Park KC, Pan R, et al. Early detection of carcinoma in situ of the bladder: a comparative study of white light cystoscopy, narrow band imaging, 5-ALA fluorescence cystoscopy and 3-dimensional optical coherence tomography[J]. J Urol, 2012, 187(3): 1063-1070.
26. 　沈益君, 朱一平, 叶定伟, 等. 窄波成像电子膀胱软镜在膀胱肿瘤诊断中的应用价值[J]. 中华泌尿外科杂志, 2010, 31(6): 383-385.
27. 　Herr H, Donat M, Dalbagni G, et al. Narrow-band imaging cystoscopy to evaluate bladder tumours--individual surgeon variability[J]. BJU Int, 2010, 106(1): 53-55.

West China Medical Journal

窄波成像在膀胱癌早期诊断中的应用进展

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