胃癌肿瘤干细胞研究现状及相关问题_West China Medical Journal

Authors：

张明鸣 , 夏霖 , 杨平 ,  伍晓汀

Corresponding author：

伍晓汀, Email: mmzhangmd@163.com

Keywords：

肿瘤干细胞; 胃癌; 胃癌干细胞

Video：

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Abstract Full text Figures/Tables Video References Cited by

肿瘤干细胞学说是近年来快速发展和备受关注的一个理论，根据该学说，具有自我更新、多向分化、无限生长和很强成瘤能力的癌干细胞可能是肿瘤发生、发展、侵袭和复发转移的根源。当前，已有多种类型的癌干细胞被证实或探讨，然而胃癌干细胞的研究尚存在困难，相关报道很少。现就国内外近年来关于癌干细胞和胃癌干细胞的相关研究进展进行综述，探讨胃癌干细胞的培养、分离、确认鉴定及其复杂的生物学特征研究中尚面临的一些亟待解决的问题。

Citation： 张明鸣,夏霖,杨平,伍晓汀. 胃癌肿瘤干细胞研究现状及相关问题. West China Medical Journal, 2012, 27(3): 452-454. doi: Copy

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1. 　Bhattacharyya S, Khanduja KL. New hope in the horizon: cancer stem cells[J]. Acta Biochim Biophys Sin (Shanghai), 2010, 42(4): 237-242.
2. 　Velasco-Velázquez MA, Popov VM, Lisanti MP, et al. The role of breast cancer stem cells in metastasis and therapeutic implications[J]. Am J Pathol, 2011, 179(1): 2-11.
3. 　Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells[J]. Nature, 2001, 414(6859): 105-111.
4. 　Scopelliti A, Cammareri P, Catalano V, et al. Therapeutic implications of cancer iitiating cells[J]. Expert Opin Biol Ther, 2009, 9(8): 1005-1016.
5. 　Subramaniam D, Ramalingam S, Houchen CW, et al. Cancer stem cells: a novel paradigm for cancer prevention and treatment[J]. Mini Rev Med Chem, 2010, 10(5): 359-371.
6. 　Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell[J]. Nat Med, 1997, 3(7): 730-737.
7. 　Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells[J]. Proc Natl Acad Sci USA, 2003, 100(7): 3983-3988.
8. 　Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumor initiating cells[J]. Nature, 2004, 432(7015): 396-401.
9. 　Collins AT, Berry PA, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem cells[J]. Cancer Res, 2005, 65(23): 10946-10951.
10. 　Li C, Lee CJ, Simeone DM. Identification of human pancreatic cancer stem cells[J]. Methods Mol Biol, 2009, 568: 161-173.
11. 　Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells[J]. Nature, 2007, 445(7123): 111-115.
12. 　Guo R, Wu Q, Liu F, et al. Description of the CD133+ subpopulation of the human ovarian cancer cell line OVCAR3[J]. Oncol Rep, 2011, 25(1): 141-146.
13. 　Yu F, Yao H, Zhu P, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells[J]. Cell, 2007, 131(6): 1109-1123.
14. 　Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors[J]. Proc Natl Acad Sci USA, 2003, 100(25): 15178-15183.
15. 　Hiraga T, Ito S, Nakamura H. Side population in MDA-MB-231 human breast cancer cells exhibits cancer stem cell-like properties without higher bone-metastatic potential[J]. Oncol Rep, 2011, 25(1): 289-296.
16. 　Hadnagy A, Gaboury L, Beaulieu R, et al. SP analysis May be used to identify cancer stem cell populations[J]. Exp Cell Res, 2006, 312(19): 3701-3710.
17. 　Triel C, Vestergaard ME, Bolund L, et al. Side population cells in human and mouse epidermis lack stem cell characteristics[J]. Exp Cell Res, 2004, 295(1): 79-90.
18. 　Gaston-Massuet C, Andoniadou CL, Signore M, et al. Increased wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans[J]. Proc Natl Acad Sci USA, 2011, 108(28): 11482-11487.
19. 　Lei Y, Huang K, Gao C, et al. Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells[J]. Mol Cell Proteomics, 2011, 10(10): M110.005397.
20. 　Dolai S, Xu Q, Liu F, et al. Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells[J]. Proteomics, 2011, 11(13): 2683-2692.
21. 　Izumiya M, Okamoto K, Tsuchiya N, et al. Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs[J]. Carcinogenesis, 2010, 31(8): 1354-1359.
22. 　Krutovskikh VA, micrornas HO. As a new class of cancer biomarkers[J]. Bioessays, 2010, 32(10): 894-904.
23. 　张祖斌, 顾振纶, 蒋小岗, 等. miRNA在肿瘤及肿瘤干细胞中作用的研究进展[J]. 中国药理学通报, 2009, 25(3): 297-299.
24. 　Kitade Y, Akao Y. MicroRNAs and their therapeutic potential for human diseases: microRNAs, miR-143 and -145, function as anti-oncomirs and the application of chemically modified miR-143 as an anti-cancer drug[J]. J Pharmacol Sci, 2010, 114(3): 276-280.
25. 　Akao Y, Nakagawa Y, Hirata I, et al. Role of anti-oncomirs miR-143 and -145 in human colorectal tumors[J]. Cancer Gene Ther, 2010, 17(6): 398-408.

West China Medical Journal

胃癌肿瘤干细胞研究现状及相关问题

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