Prognosis of Male Breast Cancer at A Single Institution_West China Medical Journal

Authors：

HAN Mei ,  ZHENG Hong , LUO Ting , SUN Yu

Oncology Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

ZHENG Hong, Email: hm-leehom@qq.com

Keywords：

男性乳腺癌; 预后; 单因素; 多因素; 生存分析

Video：

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目的　初步探讨影响男性乳腺癌患者预后的因素。　方法　收集2003年1月－2011年12月经病理确诊、接受治疗、临床资料较完整的36例男性乳腺癌患者的临床资料。采用对数秩检验和Cox回归分析影响男性乳腺癌患者预后的因素。结果　36例患者无进展生存期（PFS）为3～95个月，中位PFS为45个月。单因素分析显示：肿瘤直径（P=0.001）、阳性淋巴结（P=0.001）、TNM分期（P＜0.001）、手术方式（P=0.001）是影响预后的因素。多因素分析显示：阳性淋巴结（P=0.024）和TNM分期（P=0.022）是影响预后的主要因素。结论　阳性淋巴结和TNM分期是影响预后的主要因素，以手术为主的综合治疗模式是提高男性乳腺癌患者生存率的重要措施。

Citation： HAN Mei,ZHENG Hong,LUO Ting,SUN Yu. Prognosis of Male Breast Cancer at A Single Institution. West China Medical Journal, 2012, 27(4): 495-500. doi: Copy

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2.	Anderson WF, Althuis MD, Brinton LA, et al. Is male breast cancer similar or different than female breast cancer? [J]. Breast Cancer Res Treat, 2004, 83(1): 77-86.
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10.	Yoney A, Kucuk A, Unsal M. Male breast cancer: a retrospective analysis[J]. Cancer Radiother, 2009, 13(2): 103-107.
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15.	Gioedano SH, Cohen DS, Buzdar AU, et al. Breast carcinoma in men[J]. Cancer, 2004, 101(1): 51-57.
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17.	Zabel A, Milker-Zabel S, Zuna I, et al. External beam radiotherapy in the treatment of male breast carcinoma: patterns of failure in a single institute experience[J]. Tumori, 2005, 91(2): 151-155.
18.	Bagley CS, Wesley MN, Young RC, et al. Adjuvant chemotherapy in males with cancer of the breast[J]. J Clin Oncol, 1987, 10(1): 55-60.
19.	Chakravarthy A, Kim CR. Post-mastectomy radiation in male breast cancer[J]. Radiother Oncol, 2002, 65(2): 99-103.
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21.	Iredale R, Brain K, Williams B, et al. The experiences of men with breast cancer in the United Kingdom[J]. Eur J Cancer, 2006, 42(3): 334-341.

1. 　Cutuli B, Le-Nir CC, Serin D, et al. Evolution of treatment and prognostic factors. Analysis of 489 cases[J]. Crit Rev Oncol Hematol, 2010, 73(3): 246-254.
2. 　Anderson WF, Althuis MD, Brinton LA, et al. Is male breast cancer similar or different than female breast cancer? [J]. Breast Cancer Res Treat, 2004, 83(1): 77-86.
3. 　Giordano SH, Buzdar AU, Hortobagyi GN. Breast cancer in men[J]. Ann Intern Med, 2002, 137(8): 678-687.
4. 　Donegan WL, Redlich PN. Breast cancer in men[J]. Surg Clin North Am, 1996, 76(2): 343-363.
5. 　Goss PE, Reid C, Pintilie M, et al. Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996[J]. Cancer, 1999, 85(3): 629-639.
6. 　Malani AK. Male breast cancer: a different disease than female breast cancer[J]. South Med J, 2007, 100(2): 197.
7. 　Contractor KB, Kaur K, Rodrigues GS, et al. Male breast cancer: is the scenario changing[J]. World J Surg Oncol, 2008, 6(58): 58.
8. 　Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual[M]. 7th ed. New York: Springer, 2010: 321-325.
9. 　Speirs V, Shaaban AM. The rising incidence of male breast cancer[J]. Breast Cancer Res Treat, 2009, 115(2): 429-430.
10. 　Yoney A, Kucuk A, Unsal M. Male breast cancer: a retrospective analysis[J]. Cancer Radiother, 2009, 13(2): 103-107.
11. 　Giordano SH. A review of the diagnosis and management of male breast cancer[J]. Oncologist, 2005, 10(7): 471-479.
12. 　Meguerditchian AN, Falardeau M, Martin G. Male breast carcinoma[J]. Can J Surg, 2002, 45(4): 296-302.
13. 　Ben Dhiab T, Bouzid T, Gamoudi A, et al. Male breast cancer: about 123 cases collected at the Institute Salah-Azaiz of Tunis from 1979 to 1999[J]. Bull Cancer, 2005, 92(3): 281-285.
14. 　Comet B, Cutuli B, Penault-Llorca F, et al. Male breast cancer: a review[J]. Bull Cancer, 2009, 96(2): 181-189.
15. 　Gioedano SH, Cohen DS, Buzdar AU, et al. Breast carcinoma in men[J]. Cancer, 2004, 101(1): 51-57.
16. 　Yildirim E, Berberoğlu U. Male breast cancer: a 22-year experience[J]. Eur J Surg Oncol, 1998, 24(6): 548-552.
17. 　Zabel A, Milker-Zabel S, Zuna I, et al. External beam radiotherapy in the treatment of male breast carcinoma: patterns of failure in a single institute experience[J]. Tumori, 2005, 91(2): 151-155.
18. 　Bagley CS, Wesley MN, Young RC, et al. Adjuvant chemotherapy in males with cancer of the breast[J]. J Clin Oncol, 1987, 10(1): 55-60.
19. 　Chakravarthy A, Kim CR. Post-mastectomy radiation in male breast cancer[J]. Radiother Oncol, 2002, 65(2): 99-103.
20. 　Tarone RE, Chu KC. The greater impact of menopause on ER- than ER+ breast cancer incidence: a possible explanation (United States)[J]. Cancer Causes Control, 2002, 13(1): 7-14.
21. 　Iredale R, Brain K, Williams B, et al. The experiences of men with breast cancer in the United Kingdom[J]. Eur J Cancer, 2006, 42(3): 334-341.

West China Medical Journal

Prognosis of Male Breast Cancer at A Single Institution

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