Effects of Total Glucosides of Paeony on the Level of Interleukin-22 in the Serum of Patients with Psoriasis Vulgaris_West China Medical Journal

Authors：

ZHANG YUhong ,  GUO Zaipei , JIAO Xiaoyan , LI Mengmeng , CHEN Tao

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

GUO Zaipei, Email: zhangyuhongqq@163.com

Keywords：

白芍总苷; 寻常型银屑病; 白细胞介素-22; 角质形成细胞

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目的　通过对白芍总苷治疗前后寻常型银屑病患者血清中白介素（IL）-22水平的研究，探讨其治疗寻常型银屑病的作用机制。方法　2009年10月－2010年8月采用双抗体夹心酶联免疫吸附法，检测30例寻常型银屑病患者，经白芍总苷治疗前后及健康对照组20例外周血清中IL-22浓度的变化，分析其在治疗前、后与银屑病皮损面积和严重程度指数（PASI）评分的相关性。结果　寻常型银屑病患者血清IL-22浓度[（90.50 ± 51.80）pg/mL]较对照组[（40.10 ± 17.20）pg/mL]升高，白芍总苷治疗后血清中IL-22水平[（48.70 ± 23.90）pg/mL]较治疗前降低（P＜0.05），并与对照组差异无统计学意义（P＞0.05）；治疗前、后患者血清IL-22水平与PASI评分呈正相关。结论　白芍总苷可能通过调节IL-22发挥治疗寻常型银屑病的作用。

Citation： ZHANG YUhong,GUO Zaipei,JIAO Xiaoyan,LI Mengmeng,CHEN Tao. Effects of Total Glucosides of Paeony on the Level of Interleukin-22 in the Serum of Patients with Psoriasis Vulgaris. West China Medical Journal, 2012, 27(4): 542-544. doi: Copy

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1. 　熊承成, 刘厚君. IL-22在银屑病发病机制中的作用[J].国际皮肤性病学杂志, 2011, 37(1): 29-32.
2. 　赵辨. 临床皮肤病学[M]. 3版. 南京: 江苏科学出版社, 2001: 765.
3. 　张长宋, 赵天恩, 陈树民. 银屑病病情严重程度评判指标的研究现状[J]. 国际皮肤性病学杂志, 2002, 28(2): 82-84.
4. 　Ghoreschi K, Weigert C, Röcken M. Immunopathogenesis and role of T cells in psoriasis[J]. Clin Dermatol, 2007, 25(6): 574-580.
5. 　Res PC, Piskin G, de Boer OJ, et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis[J]. PLoS One, 2010, 5(11): e14108.
6. 　Dumoutier L, Louahed J, Renauld JC. Characterication of IL-10-related Tcell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9[J]. J Immunol, 2000, 164(4): 1814-1819.
7. 　Duhen T, Geiger R, Jarrossay D, et al. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells[J]. Nat Immunol, 2009, 10(8): 857-863.
8. 　Nograles KE, Zaba LC, Guttman-Yassky E, et al. Th17 cytokines interleukin(IL)-17 and IL-22 modulate distinct inﬂammatory and keratinocyte-response pathways[J]. Br J Dermatol, 2008, 159(5): 1092-1102.
9. 　Boniface K, Guignouard E, Pedretti N, et al. A role for T cell-derived interleukin 22 in psoriatic skin inﬂammation[J]. Clin Exp Immunol, 2007, 150(3): 407-415.
10. 　关小红, 王宁丽. 白芍总苷对寻常性斑块状银屑病外周血T细胞亚群的影响[J]. 河南中医, 2010, 30(5): 455-456.
11. 　张宇虹, 郭在培, 焦晓燕, 等. 白芍总苷治疗寻常型银屑病的临床观察[J]. 临床皮肤科杂志, 2011, 40(7): 433-435.
12. 　李传应, 王春, 魏伟. 白芍总苷对小鼠慢性皮炎-湿疹的治疗作用及其部分机制[J]. 中国药理学通报, 2008, 24(10): 1366-1369.
13. 　王佐, 吴正祥, 杨九华, 等. 白芍总甙对大鼠实验性结肠炎Th17细胞相关因子的作用[J]. 世界华人消化杂志, 2010, 18(1): 84-88.

West China Medical Journal

Effects of Total Glucosides of Paeony on the Level of Interleukin-22 in the Serum of Patients with Psoriasis Vulgaris

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