Clinical Research on the Influence of Systane Lubricant Eye Drops on the Formation of Corneal Haze after Laser Epithelial Keratomileusis_West China Medical Journal

Authors：

TAN Yeshuang , ZHOUXia , SUN Bin , PAN Guiping

Department of Ophthalmology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P. R. China;

Corresponding author：

Keywords：

准分子激光上皮下角膜磨镶术; 聚乙二醇滴眼液; 角膜雾状混浊

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目的　探讨聚乙二醇滴眼液对准分子激光上皮下角膜磨镶术（LASEK）后角膜雾状混浊（haze）影响的临床研究。方法　回顾性分析2009年3月－2010年3月行LASEK的患者45例90只眼的临床资料。患者屈光度（?4.68 ± 2.30）D（?1.75～?6.50 D），随机分为聚乙二醇滴眼液组（试验组）和对照组，术后定期随访观察两组角膜haze形成、角膜上皮愈合时间、视力恢复情况及屈光度。结果　术后1、3、6个月，两组haze形成差异无统计学意义（P＞0.05），试验组术后第1、3、5天角膜刺激症状明显轻于对照组（P＜0.05），上皮愈合速度较对照组更快（P＜0.05）。结论　LASEK术后应用聚乙二醇滴眼液虽然能减轻术后患者角膜刺激症状,能促进角膜上皮更快愈合，但是不能减轻haze的形成。

Citation： TAN Yeshuang,ZHOUXia,SUN Bin,PAN Guiping. Clinical Research on the Influence of Systane Lubricant Eye Drops on the Formation of Corneal Haze after Laser Epithelial Keratomileusis. West China Medical Journal, 2012, 27(4): 567-569. doi: Copy

1.	Kornilovsky IM. Clinical results after subepithelial photorefractive keratectomy (LASEK)[J]. J Refract Surg, 2001, 17(2): 222-223.
2.	Lee JB , Seong GJ , Lee J H , et al. Comparison of laser epithelial keratomileusis and photorefractive keratectomy for low to moderate myopia[J]. J Cataract Refract Surg, 2001, 27(4): 565-570.
3.	谭业双, 刘磊, 李新宇. LASEK术后Haze的发病机制与防治的研究进展[J].眼科新进展, 2007, 27(7): 546-548.
4.	赵家良, 黎晓新, 董冬生, 等. 普拉洛芬滴眼液治疗白内障术后炎症和非感染性眼前段炎症的临床评价[J]. 眼科研究, 2000, 18(6): 560-564.
5.	Fantes FE, Hanna KD, Waring GO, et al. Wound healing afterexcimer laser keratomileusis (photorefractive keratectomy) in monkeys[J]. Arch Ophthalmol, 1990, 108(5): 665-675.
6.	Camellin M.LASEK may after the advantages of both lasik and PRK[J]. Ocu Surg N Int， 1999, 10(3): 14-15 .
7.	Scerrati E. Laser in situ keratomileusis vs laser epithelial keratomileusis (LASIK vs LASEK) [J]. J RefractSurg, 2001, 17(2): 219-221.
8.	Hersh PS, Stulting RD, Steinert RF, et al. Results of Phase Ⅲexcimer laser photorefractive keratectomy for myopia; the Summit PRK Study Group[J]. Ophthalmology, 1997, 104(10): 1535-1553.
9.	Kremer I, Kaplan A, Novikov I, et al. Patterns of late corneal scarring after photorefractive keratectomy in high and severe myopia[J]. Ophthalmology, 1999, 106(3): 467-473.
10.	Cua IY, Pepose JS. Late corneal scarring after photorefractive keratectomy concurrent with the development of systemic lupus erythematosus[J]. J Refract Surg, 2002, 18(6): 750-752.
11.	Stojanovic A, Nitter TA. Correlation between ultraviolet radiation level and the incidence of late-onset corneal haze after photorefractive keratectomy[J]. J Cataract Refract Surg, 2001, 27(3): 404-410.
12.	Mocanu C, Bǎrǎscu D, B rjovanu F, et al. Assessment of systane in severe dry eye[J]. Oftalmologia, 2008, 52(1): 105-110.
13.	Gifford P, Evans BJ, Morris J. A clinical evaluation of Systane[J]. Cont Lens Anterior Eye, 2006, 29(1): 31-40.
14.	David K. A two-week clinical evaluation of the safety of systane ultra in contact lens-wearing patients [J]. Clin Ophthalmol, 2010, 4(2): 27-32.
15.	Wang MX, Gray TB, Clan PW, et al. Reduction in corneal haze apoptosis by amniotic membrane matrix in excimer laser photo ablation in rabbits[J]. J Caratact Refract Surg, 2001, 27(2): 310 -319.
16.	Netto MV, Mohan RR, Ambrósio R Jr, et al.Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy[J]. Cornea, 2005, 24(5): 509-522.

1. 　Kornilovsky IM. Clinical results after subepithelial photorefractive keratectomy (LASEK)[J]. J Refract Surg, 2001, 17(2): 222-223.
2. 　Lee JB , Seong GJ , Lee J H , et al. Comparison of laser epithelial keratomileusis and photorefractive keratectomy for low to moderate myopia[J]. J Cataract Refract Surg, 2001, 27(4): 565-570.
3. 　谭业双, 刘磊, 李新宇. LASEK术后Haze的发病机制与防治的研究进展[J].眼科新进展, 2007, 27(7): 546-548.
4. 　赵家良, 黎晓新, 董冬生, 等. 普拉洛芬滴眼液治疗白内障术后炎症和非感染性眼前段炎症的临床评价[J]. 眼科研究, 2000, 18(6): 560-564.
5. 　Fantes FE, Hanna KD, Waring GO, et al. Wound healing afterexcimer laser keratomileusis (photorefractive keratectomy) in monkeys[J]. Arch Ophthalmol, 1990, 108(5): 665-675.
6. 　Camellin M.LASEK may after the advantages of both lasik and PRK[J]. Ocu Surg N Int， 1999, 10(3): 14-15 .
7. 　Scerrati E. Laser in situ keratomileusis vs laser epithelial keratomileusis (LASIK vs LASEK) [J]. J RefractSurg, 2001, 17(2): 219-221.
8. 　Hersh PS, Stulting RD, Steinert RF, et al. Results of Phase Ⅲexcimer laser photorefractive keratectomy for myopia; the Summit PRK Study Group[J]. Ophthalmology, 1997, 104(10): 1535-1553.
9. 　 Kremer I, Kaplan A, Novikov I, et al. Patterns of late corneal scarring after photorefractive keratectomy in high and severe myopia[J]. Ophthalmology, 1999, 106(3): 467-473.
10. 　Cua IY, Pepose JS. Late corneal scarring after photorefractive keratectomy concurrent with the development of systemic lupus erythematosus[J]. J Refract Surg, 2002, 18(6): 750-752.
11. 　Stojanovic A, Nitter TA. Correlation between ultraviolet radiation level and the incidence of late-onset corneal haze after photorefractive keratectomy[J]. J Cataract Refract Surg, 2001, 27(3): 404-410.
12. 　Mocanu C, Bǎrǎscu D, B rjovanu F, et al. Assessment of systane in severe dry eye[J]. Oftalmologia, 2008, 52(1): 105-110.
13. 　Gifford P, Evans BJ, Morris J. A clinical evaluation of Systane[J]. Cont Lens Anterior Eye, 2006, 29(1): 31-40.
14. 　David K. A two-week clinical evaluation of the safety of systane ultra in contact lens-wearing patients [J]. Clin Ophthalmol, 2010, 4(2): 27-32.
15. 　Wang MX, Gray TB, Clan PW, et al. Reduction in corneal haze apoptosis by amniotic membrane matrix in excimer laser photo ablation in rabbits[J]. J Caratact Refract Surg, 2001, 27(2): 310 -319.
16. 　Netto MV, Mohan RR, Ambrósio R Jr, et al.Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy[J]. Cornea, 2005, 24(5): 509-522.

West China Medical Journal

Clinical Research on the Influence of Systane Lubricant Eye Drops on the Formation of Corneal Haze after Laser Epithelial Keratomileusis

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