降压药对老年高血压患者动脉弹性功能的影响_West China Medical Journal

Authors：

赵艳萍 ,  张新军

Corresponding author：

张新军, Email: zhaozhixin.ok@163.com

Keywords：

老年高血压; 药物治疗; 动脉弹性功能

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老年原发性高血压患者中，单纯收缩期高血压更常见，是心血管疾病的重要危险因素，主要归因于弹性动脉僵硬度增加。年龄和血压水平是影响动脉弹性功能的重要因素，而大动脉弹性功能减退是高血压患者并发心脑血管意外的重要病理生理基础，动脉壁结构和功能的改变是高血压疾病发生发展的早期标志。尽管不同种类降压药物在降压水平上总体差别很小，但对大动脉顺应性的改变有所不同。

Citation： 赵艳萍,张新军. 降压药对老年高血压患者动脉弹性功能的影响. West China Medical Journal, 2012, 27(4): 626-629. doi: Copy

1.	王妍, 陶军, 杨震, 等. 增龄和高血压病对动脉弹性功能的影响[J]. 中华现代内科学杂志, 2005, 2(9): 769-771.
2.	Tao J, Jin Y, Wang L, et al. In vivo adaptive response of the peripheral conduit artery in patients with borderline systolic hypertension[J]. Chin Med J, 2003, 116(3): 333-336.
3.	王宏宇, 倪永斌, 龚兰生, 等. 老年高血压患者大动脉弹性研究[J]. 中国老年学杂志, 2003, 23(1): 10-12.
4.	Mackenzie IS, McEniery CM, Dhakam Z, et al.Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension[J]. Hypertension, 2009, 54(2): 409-413.
5.	Gasowski J, Fagard RH, Staessen JA, et al. Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups [J]. J Hypertens, 2002, 20(1): 145-151.
6.	Strbova J, Kmecova J, Klimas J. Elevated pulse pressure in treated hypertensive patients during 24-hour ambulatory blood pressure monitoring[J]. Bratisl Lek Listy, 2011, 112(10): 562-567.
7.	张晶, 关欣, 梁伯平, 等. 原发性高血压患者颈动脉粥样硬化的临床意义[J].中国心血管杂志, 2006, 11(4): 286-288.
8.	Lee SW, Hai JJ, Kong SL, et al. Side differences of carotid intima-media thickness in predicting cardiovascular events among patients with coronary artery disease[J]. Angiology, 2011, 62(3): 231-236.
9.	Cohn JN, Finkelstein S, McVeigh G, et al. Noninvasive pulse wave analysis for the early detection of the vascular disease[J]. Hypertension, 1995, 26(3): 503-508.
10.	Gupta V, Sachdeva S, Khan AS, et al. Endothelial dysfunction and inflammation in different stages of essential hypertension[J].Saudi J Kidney Dis Transpl, 2011, 22(1): 97-103.
11.	周淑娴, 雷娟, 张玉玲, 等. 高血压患者胰岛素抵抗与血清脂联素及炎症标志物水平[J]. 中华高血压杂志, 2008, 16(2): 166-170.
12.	Marchesi C, Paradis P, Schiffrin EL. Role of the rennin-angiotension system in vascular inflammation[J]. Trends pharmacol Sci, 2008, 29(7): 367-374.
13.	Schmieder RE, Hilgers KF, Schlaich MP, et al. Renin-angiotensin system and cardiovascular risk[J]. Lancet, 2007, 369(9568): 1208-1219.
14.	Marketou ME, Kontaraki JE, Tsakountakis NA, et al. Differential effect of telmisartan and amlodipine on monoctyte chemoattractant protein-1 and peroxisome proliferator-activated receptor-gamma gene expression in peripheral monocytes in patients with essential hypertension[J]. Am J Cardiol, 2011, 107(1): 59-63.
15.	Mahmud A, Feely J. Aldosterone-to-renin ratio, arterial stiffness, and the response to aldosterone antagonism in essential hypertension[J].Am J Hypertens, 2005, 18(1): 50-55.
16.	王均生, 刘地川. 贝那普利对原发性高血压患者肿瘤坏死因子-α、白细胞介素-6和C 反应蛋白的影响[J]. 临床心血管病杂志, 2011, 27(6): 417-418.
17.	Lchihara A, Hayashi M, Kaneshiro Y, et al. Low doses of losartan and trandolapril improve arterial stiffness in hemodialysis patients[J]. Am J Kidney Dis, 2005, 45(5): 866-874.
18.	Ferguson JM, Minas J, Siapantas S, et al. Effects of a fixed-dose ACE inhibitor-diuretic combination on ambulatory blood pressure and arterial properties in isolated systolic hypertension[J]. J Cardiovasc Pharmacol, 2008, 51(6): 590-595.
19.	Simon AC, Levenson JA, Safar AM, et al. ACE inhibition and brachial artery haemodynamics in hypertension[J].Br J Clin Pharmacol, 1984, 18(Suppl 2): 243-247.
20.	Zou Z, Xi GL, Yuan HB, et al. Telmisartan versus angiotension-converting enzyme inhibitors in the treatment of hypertension: a meta-analysis of randomized controlled trials[J]. J Hum Hypertens, 2009, 23(5): 339-349.
21.	Wang JG, Staessen JA, Li Y, et al. Carotid intima-media thicknedd and antihypertensive treatment: a meta-analysis of randomized controlled trials[J]. Stroke, 2006, 37(7): 1933-1940.
22.	翟丽华, 王沙燕, 梁旭, 等. 氨氯地平逆转颈动脉内中膜增厚作用与血管紧张素转换酶基因型的相关性[J]. 中华心血管病杂志, 2008, 36(6): 510-513.
23.	牛红育, 张麟. 非洛地平缓释片对老年原发性高血压患者大动脉顺应性的影响[J]. 中华老年心脑血管病杂志, 2010, 12(4): 316-318.
24.	Dahlöf B, Devereux RB, Kjeldsen SE, et al. Cardiovascular mobidity and mortality in the Losartan Intervention for Endpoint Reduction in Hypertension Study (LIFE): a randomized trial against atenolol[J]. Lancet, 2002, 359(9311): 995-1003.
25.	Dahlöf B, Sever PS, Poulter NR, et al. Prevention of cardiovascular events with an antihypertensive regimen ofamlodipine adding perindopril as required versus atenolol addingbendroflumethiazide as required, in the Anglo-Scandinavian Cardiac OutcomesTrial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial [J]. Lancet, 2005, 366(9489): 895-906.
26.	Bradley HA, Wiysonge CS, Volmink JA. How strong is the evidence for use of beta-blockers as first-line therapy for hypertension？ Systematic review and meta-analysis[J]. Hypertension, 2006, 24(11): 2131-2141.
27.	Lindholm LH, Carlberg B, Samuelsson O. Should βblockers remain first choice in the treatment of primary hypertension? A meta-analysis[J]. Lancet, 2005, 366(9496): 1545-1553.
28.	Schiffrin EL, Pu Q, Park JB. Effect of amlodipine compared to atenolol on small arteries of previously untreated essential hypertension patients[J]. Am J Hypertens, 2002, 15(2 Pt 1): 105-110.
29.	Schiffrin EL, Park JB, Pu Q. Effect of crossing over hypertensive patients from a beta-blocker to an angiotensin receptor antagonist on resistance artery structure and on endothelial function[J]. J Hypertens, 2002, 20(1): 71-78.
30.	Ferguson JM, Lustermans FA, Breed JG, et al. The influence of perindopril and the diuretic combination amiloride+hydrochlorothiazide on the vessel wall properties of large arteries in hypertensive patients[J]. J Hypertens, 1995, 13(8): 839-848.
31.	中华医学会心血管病学分会高血压学组. 利尿剂治疗高血压的中国专家共识[J]. 中华高血压杂志, 2011, 19(3): 214-222.

1. 　王妍, 陶军, 杨震, 等. 增龄和高血压病对动脉弹性功能的影响[J]. 中华现代内科学杂志, 2005, 2(9): 769-771.
2. 　Tao J, Jin Y, Wang L, et al. In vivo adaptive response of the peripheral conduit artery in patients with borderline systolic hypertension[J]. Chin Med J, 2003, 116(3): 333-336.
3. 　王宏宇, 倪永斌, 龚兰生, 等. 老年高血压患者大动脉弹性研究[J]. 中国老年学杂志, 2003, 23(1): 10-12.
4. 　Mackenzie IS, McEniery CM, Dhakam Z, et al.Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension[J]. Hypertension, 2009, 54(2): 409-413.
5. 　Gasowski J, Fagard RH, Staessen JA, et al. Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups [J]. J Hypertens, 2002, 20(1): 145-151.
6. 　Strbova J, Kmecova J, Klimas J. Elevated pulse pressure in treated hypertensive patients during 24-hour ambulatory blood pressure monitoring[J]. Bratisl Lek Listy, 2011, 112(10): 562-567.
7. 　张晶, 关欣, 梁伯平, 等. 原发性高血压患者颈动脉粥样硬化的临床意义[J].中国心血管杂志, 2006, 11(4): 286-288.
8. 　Lee SW, Hai JJ, Kong SL, et al. Side differences of carotid intima-media thickness in predicting cardiovascular events among patients with coronary artery disease[J]. Angiology, 2011, 62(3): 231-236.
9. 　Cohn JN, Finkelstein S, McVeigh G, et al. Noninvasive pulse wave analysis for the early detection of the vascular disease[J]. Hypertension, 1995, 26(3): 503-508.
10. 　Gupta V, Sachdeva S, Khan AS, et al. Endothelial dysfunction and inflammation in different stages of essential hypertension[J].Saudi J Kidney Dis Transpl, 2011, 22(1): 97-103.
11. 　周淑娴, 雷娟, 张玉玲, 等. 高血压患者胰岛素抵抗与血清脂联素及炎症标志物水平[J]. 中华高血压杂志, 2008, 16(2): 166-170.
12. 　Marchesi C, Paradis P, Schiffrin EL. Role of the rennin-angiotension system in vascular inflammation[J]. Trends pharmacol Sci, 2008, 29(7): 367-374.
13. 　Schmieder RE, Hilgers KF, Schlaich MP, et al. Renin-angiotensin system and cardiovascular risk[J]. Lancet, 2007, 369(9568): 1208-1219.
14. 　Marketou ME, Kontaraki JE, Tsakountakis NA, et al. Differential effect of telmisartan and amlodipine on monoctyte chemoattractant protein-1 and peroxisome proliferator-activated receptor-gamma gene expression in peripheral monocytes in patients with essential hypertension[J]. Am J Cardiol, 2011, 107(1): 59-63.
15. 　Mahmud A, Feely J. Aldosterone-to-renin ratio, arterial stiffness, and the response to aldosterone antagonism in essential hypertension[J].Am J Hypertens, 2005, 18(1): 50-55.
16. 　王均生, 刘地川. 贝那普利对原发性高血压患者肿瘤坏死因子-α、白细胞介素-6和C 反应蛋白的影响[J]. 临床心血管病杂志, 2011, 27(6): 417-418.
17. 　Lchihara A, Hayashi M, Kaneshiro Y, et al. Low doses of losartan and trandolapril improve arterial stiffness in hemodialysis patients[J]. Am J Kidney Dis, 2005, 45(5): 866-874.
18. 　Ferguson JM, Minas J, Siapantas S, et al. Effects of a fixed-dose ACE inhibitor-diuretic combination on ambulatory blood pressure and arterial properties in isolated systolic hypertension[J]. J Cardiovasc Pharmacol, 2008, 51(6): 590-595.
19. 　Simon AC, Levenson JA, Safar AM, et al. ACE inhibition and brachial artery haemodynamics in hypertension[J].Br J Clin Pharmacol, 1984, 18(Suppl 2): 243-247.
20. 　Zou Z, Xi GL, Yuan HB, et al. Telmisartan versus angiotension-converting enzyme inhibitors in the treatment of hypertension: a meta-analysis of randomized controlled trials[J]. J Hum Hypertens, 2009, 23(5): 339-349.
21. 　Wang JG, Staessen JA, Li Y, et al. Carotid intima-media thicknedd and antihypertensive treatment: a meta-analysis of randomized controlled trials[J]. Stroke, 2006, 37(7): 1933-1940.
22. 　翟丽华, 王沙燕, 梁旭, 等. 氨氯地平逆转颈动脉内中膜增厚作用与血管紧张素转换酶基因型的相关性[J]. 中华心血管病杂志, 2008, 36(6): 510-513.
23. 　牛红育, 张麟. 非洛地平缓释片对老年原发性高血压患者大动脉顺应性的影响[J]. 中华老年心脑血管病杂志, 2010, 12(4): 316-318.
24. 　Dahlöf B, Devereux RB, Kjeldsen SE, et al. Cardiovascular mobidity and mortality in the Losartan Intervention for Endpoint Reduction in Hypertension Study (LIFE): a randomized trial against atenolol[J]. Lancet, 2002, 359(9311): 995-1003.
25. 　Dahlöf B, Sever PS, Poulter NR, et al. Prevention of cardiovascular events with an antihypertensive regimen ofamlodipine adding perindopril as required versus atenolol addingbendroflumethiazide as required, in the Anglo-Scandinavian Cardiac OutcomesTrial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial [J]. Lancet, 2005, 366(9489): 895-906.
26. 　Bradley HA, Wiysonge CS, Volmink JA. How strong is the evidence for use of beta-blockers as first-line therapy for hypertension？ Systematic review and meta-analysis[J]. Hypertension, 2006, 24(11): 2131-2141.
27. 　Lindholm LH, Carlberg B, Samuelsson O. Should βblockers remain first choice in the treatment of primary hypertension? A meta-analysis[J]. Lancet, 2005, 366(9496): 1545-1553.
28. 　Schiffrin EL, Pu Q, Park JB. Effect of amlodipine compared to atenolol on small arteries of previously untreated essential hypertension patients[J]. Am J Hypertens, 2002, 15(2 Pt 1): 105-110.
29. 　Schiffrin EL, Park JB, Pu Q. Effect of crossing over hypertensive patients from a beta-blocker to an angiotensin receptor antagonist on resistance artery structure and on endothelial function[J]. J Hypertens, 2002, 20(1): 71-78.
30. 　Ferguson JM, Lustermans FA, Breed JG, et al. The influence of perindopril and the diuretic combination amiloride+hydrochlorothiazide on the vessel wall properties of large arteries in hypertensive patients[J]. J Hypertens, 1995, 13(8): 839-848.
31. 　中华医学会心血管病学分会高血压学组. 利尿剂治疗高血压的中国专家共识[J]. 中华高血压杂志, 2011, 19(3): 214-222.

West China Medical Journal

降压药对老年高血压患者动脉弹性功能的影响

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