A Study of Resting State Functional Magnetic Resonance Imaging in Patients with Posttraumatic Stress Disorder Using Regional Homogeneity_West China Medical Journal

Authors：

ZHU Hongru ¹ , ZHANG Junran ² , QIU Changjian ¹ , WU Ruizhi ¹ , MENG Yajing ¹ , CUI Haofei ¹ , GONG Qiyong ³ ,  ZHANG Wei ¹

1. Mental Health Center, West China Hospital; 2. School of Electrical Engineering and Information; 3. Huaxi MR Research Center, Department of Radiology, West China Hospital; Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

ZHANG Wei, Email: wisepig119@163.com

Keywords：

创伤后应激障碍; 功能磁共振成像; 静息状态; 局部一致性; 地震

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　利用局部一致性（ReHo）方法探测创伤后应激障碍（PTSD）患者在静息状态下是否存在着大脑功能异常。方法　2010年5月－7月对18例未经治疗的地震PTSD患者和19例同样经历地震但未患PTSD的对照者进行了静息态功能磁共振成像（Rs-fMRI）扫描。应用ReHo方法处理Rs-fMRI数据，得出PTSD患者的异常脑区，并将患者存在组间差异的脑区ReHo值与临床用PTSD诊断量表（CAPS）、汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）分别进行相关分析。结果　① PTSD组ReHo显著增加的脑区包括右侧颞下回、楔前叶、顶下叶、中扣带回，左侧枕中回以及左/右侧后扣带回；ReHo显著降低的脑区包括左侧海马和左/右侧腹侧前扣带回。② 异常脑区中后扣带回和右侧中扣带回ReHo与HAMD呈负相关（中扣带回r=?0.575，P=0.012；右侧后扣带回：r=?0.507，P=0.032），其余脑区ReHo与临床指标无明显相关性（P＞0.05），左侧海马与CAPS的相关性相对其他脑区较大（r=?0.430，P=0.075）。结论　PTSD患者在静息状态下即存在着局部脑功能活动的降低和增加，ReHo方法可能有助于研究PTSD患者静息状态脑活动。

Citation： ZHU Hongru,ZHANG Junran,QIU Changjian,WU Ruizhi,MENG Yajing,CUI Haofei,GONG Qiyong,ZHANG Wei. A Study of Resting State Functional Magnetic Resonance Imaging in Patients with Posttraumatic Stress Disorder Using Regional Homogeneity. West China Medical Journal, 2012, 27(5): 641-646. doi: Copy

1.	Woon FL, Sood S, Hedges DW. Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(7): 1181-1188.
2.	Lui S, Huang X, Chen L, et al. High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China[J]. Proc Natl Acad Sci USA, 2009, 106(36): 15412-15417.
3.	Robinson BL, Shergill SS. Imaging in posttraumatic stress disorder[J]. Curr Opin Psychiatry, 2011, 24(1): 29-33.
4.	Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis[J]. Neuroimage, 2004, 22(1): 394-400.
5.	Shukla DK, Keehn B, Muller RA. Regional homogeneity of fMRI time series in autism spectrum disorders[J]. Neurosci Lett, 2010, 476(1): 46-51.
6.	Yuan YG, Zhang ZJ, Bai F, et al. Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study[J]. J Affect Disord, 2008, 111(2-3): 145-152.
7.	Morgan VL, Price RR, Arain A, et al. Resting functional MRI with temporal clustering analysis for localization of epileptic activity without EEG[J]. Neuroimage, 2004, 21(1): 473-481.
8.	Etkin A, Egner T, Kalisch R. Emotional processing in anterior cingulate and medial prefrontal cortex[J]. Trends Cogn Sci, 2011, 15(2): 85-93.
9.	Straube T, Schmidt S, Weiss T, et al. Dynamic activation of the anterior cingulate cortex during anticipatory anxiety[J]. Neuroimage, 2009, 44(3): 975-981.
10.	Shin LM, Wright CI, Cannistraro PA, et al. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder[J]. Arch Gen Psychiatry, 2005, 62(3): 273-281.
11.	Karl A, Schaefer M, Malta LS, et al. A meta-analysis of structural brain abnormalities in PTSD[J]. Neurosci Biobehav Rev, 2006, 30(7): 1004-1031.
12.	Geuze E, Vermetten E, Ruf M, et al. Neural correlates of associative learning and memory in veterans with posttraumatic stress disorder[J]. J Psychiatr Res, 2008, 42(8): 659-669.
13.	武瑞芝, 张俊然, 邱昌建, 等. 地震创伤后应激障碍患者脑静息态默认网络研究[J]. 四川大学学报(医学版), 2011, 42(3): 397-400.
14.	Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates[J]. Brain, 2006, 129(Pt 3): 564-583.
15.	Hayes JP, Labar KS, McCarthy G, et al. Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD[J]. J Psychiatr Res, 2011, 45(5): 660-669.
16.	Maddock RJ, Garrett AS, Buonocore MH. Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task[J]. Hum Brain Mapp, 2003, 18(1): 30-41.
17.	Bluhm RL, Williamson PC, Osuch EA, et al. Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma[J]. J Psychiatry Neurosci, 2009, 34(3): 187-94.
18.	Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex[J]. Trends Cogn Sci, 2000, 4(6): 215-222.
19.	Milad MR, Quirk GJ, Pitman RK, et al. A role for the human dorsal anterior cingulate cortex in fear expression[J]. Biol Psychiatry, 2007, 62(10): 1191-1194.
20.	Derbyshire SW. Exploring the pain “neuromatrix”[J]. Curr Rev Pain, 2000, 4(6): 467-477.
21.	Shin LM, Lasko NB, Macklin ML, et al. Resting metabolic activity in the cingulate cortex and vulnerability to posttraumatic stress disorder[J]. Arch Gen Psychiatry, 2009, 66(10): 1099-1107.
22.	Hamilton JP, Chen G, Thomason ME, et al. Investigating neural primacy in Major Depressive Disorder: multivariate Granger causality analysis of resting-state fMRI time-series data[J]. Mol Psychiatry, 2011, 16(7): 763-772.
23.	Lanius RA, Williamson PC, Densmore M, et al. The nature of traumatic memories: a 4-T FMRI functional connectivity analysis[J]. Am J Psychiatry, 2004, 161(1): 36-44.
24.	黄清玲, 卢光明, 张志强, 等. 创伤后应激障碍静息状态下脑fMRI的研究[J]. 临床放射学杂志, 2009, 28(6): 750-754.
25.	Bonne O, Gilboa A, Louzoun Y, et al. Resting regional cerebral perfusion in recent posttraumatic stress disorder[J]. Biol Psychiatry, 2003, 54(10): 1077-1086.
26.	Fischer KW. Dynamic cycles of cognitive and brain development: measuring growth in mind, brain, and education[M]//Battro AM, Fischer KW, Léna P. The educated brain. Cambridge: Cambridge University Press, 2008: 127-150.
27.	隋双戈. 性侵害创伤干预模式, 性侵害PTSD患者心理社会因素及脑结构功能特征研究[D]. 长沙: 中南大学, 2010.
28.	谢晟, 肖江喜, 白静, 等. 正常老年人无意义图形记忆任务的fMRI研究[J]. 中国医学影像技术, 2004, 20(4): 571-574.

1. 　Woon FL, Sood S, Hedges DW. Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(7): 1181-1188.
2. 　Lui S, Huang X, Chen L, et al. High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China[J]. Proc Natl Acad Sci USA, 2009, 106(36): 15412-15417.
3. 　Robinson BL, Shergill SS. Imaging in posttraumatic stress disorder[J]. Curr Opin Psychiatry, 2011, 24(1): 29-33.
4. 　Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis[J]. Neuroimage, 2004, 22(1): 394-400.
5. 　Shukla DK, Keehn B, Muller RA. Regional homogeneity of fMRI time series in autism spectrum disorders[J]. Neurosci Lett, 2010, 476(1): 46-51.
6. 　Yuan YG, Zhang ZJ, Bai F, et al. Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study[J]. J Affect Disord, 2008, 111(2-3): 145-152.
7. 　Morgan VL, Price RR, Arain A, et al. Resting functional MRI with temporal clustering analysis for localization of epileptic activity without EEG[J]. Neuroimage, 2004, 21(1): 473-481.
8. 　Etkin A, Egner T, Kalisch R. Emotional processing in anterior cingulate and medial prefrontal cortex[J]. Trends Cogn Sci, 2011, 15(2): 85-93.
9. 　Straube T, Schmidt S, Weiss T, et al. Dynamic activation of the anterior cingulate cortex during anticipatory anxiety[J]. Neuroimage, 2009, 44(3): 975-981.
10. 　Shin LM, Wright CI, Cannistraro PA, et al. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder[J]. Arch Gen Psychiatry, 2005, 62(3): 273-281.
11. 　Karl A, Schaefer M, Malta LS, et al. A meta-analysis of structural brain abnormalities in PTSD[J]. Neurosci Biobehav Rev, 2006, 30(7): 1004-1031.
12. 　Geuze E, Vermetten E, Ruf M, et al. Neural correlates of associative learning and memory in veterans with posttraumatic stress disorder[J]. J Psychiatr Res, 2008, 42(8): 659-669.
13. 　武瑞芝, 张俊然, 邱昌建, 等. 地震创伤后应激障碍患者脑静息态默认网络研究[J]. 四川大学学报(医学版), 2011, 42(3): 397-400.
14. 　Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates[J]. Brain, 2006, 129(Pt 3): 564-583.
15. 　Hayes JP, Labar KS, McCarthy G, et al. Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD[J]. J Psychiatr Res, 2011, 45(5): 660-669.
16. 　Maddock RJ, Garrett AS, Buonocore MH. Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task[J]. Hum Brain Mapp, 2003, 18(1): 30-41.
17. 　Bluhm RL, Williamson PC, Osuch EA, et al. Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma[J]. J Psychiatry Neurosci, 2009, 34(3): 187-94.
18. 　Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex[J]. Trends Cogn Sci, 2000, 4(6): 215-222.
19. 　Milad MR, Quirk GJ, Pitman RK, et al. A role for the human dorsal anterior cingulate cortex in fear expression[J]. Biol Psychiatry, 2007, 62(10): 1191-1194.
20. 　Derbyshire SW. Exploring the pain “neuromatrix”[J]. Curr Rev Pain, 2000, 4(6): 467-477.
21. 　Shin LM, Lasko NB, Macklin ML, et al. Resting metabolic activity in the cingulate cortex and vulnerability to posttraumatic stress disorder[J]. Arch Gen Psychiatry, 2009, 66(10): 1099-1107.
22. 　Hamilton JP, Chen G, Thomason ME, et al. Investigating neural primacy in Major Depressive Disorder: multivariate Granger causality analysis of resting-state fMRI time-series data[J]. Mol Psychiatry, 2011, 16(7): 763-772.
23. 　Lanius RA, Williamson PC, Densmore M, et al. The nature of traumatic memories: a 4-T FMRI functional connectivity analysis[J]. Am J Psychiatry, 2004, 161(1): 36-44.
24. 　黄清玲, 卢光明, 张志强, 等. 创伤后应激障碍静息状态下脑fMRI的研究[J]. 临床放射学杂志, 2009, 28(6): 750-754.
25. 　Bonne O, Gilboa A, Louzoun Y, et al. Resting regional cerebral perfusion in recent posttraumatic stress disorder[J]. Biol Psychiatry, 2003, 54(10): 1077-1086.
26. 　Fischer KW. Dynamic cycles of cognitive and brain development: measuring growth in mind, brain, and education[M]//Battro AM, Fischer KW, Léna P. The educated brain. Cambridge: Cambridge University Press, 2008: 127-150.
27. 　隋双戈. 性侵害创伤干预模式, 性侵害PTSD患者心理社会因素及脑结构功能特征研究[D]. 长沙: 中南大学, 2010.
28. 　谢晟, 肖江喜, 白静, 等. 正常老年人无意义图形记忆任务的fMRI研究[J]. 中国医学影像技术, 2004, 20(4): 571-574.

West China Medical Journal

A Study of Resting State Functional Magnetic Resonance Imaging in Patients with Posttraumatic Stress Disorder Using Regional Homogeneity

Abstract Full text Figures/Tables Video References Cited by

Format

Content