Application of Arterial Stiffness and Ankle Brachial Index in Evaluating Peripheral Arteriosclerosis in Elderly Patients with Type 2 Diabetes_West China Medical Journal

Authors：

WU Jichuan ¹ ,  LIU Tianhu ² , GUO Huali ² , YANG Jing ² , WANG Hongyu ³

Department of Endocrinology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

LIU Tianhu, Email: Wujichuan55@163.com

Keywords：

老年，2型糖尿病; 动脉僵硬度; 踝臂指数

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目的　了解老年2型糖尿病动脉僵硬度与踝臂指数（ABI）对评价外周动脉硬化的价值。方法　2010年1月－3月，应用超声、回声跟踪技术和动脉硬化检测仪检测80例老年2型糖尿病患者（观察组）和40例正常老年人（对照组）的颈总动脉内中膜厚度（IMT）、僵硬系数（β）、脉搏波传导速度（PWVβ）、ABI及动脉斑块情况。结果　与对照组比较，观察组患者的IMT增厚、β增高、PWVβ增快、ABI降低及动脉斑块发生率增多，差异均具有统计学意义（P＜0.001）。结论　老年2型糖尿病可导致IMT增厚、动脉僵硬度增高、PWVβ增快、ABI降低及更易发生动脉粥样硬化斑块，这些参数可以预测外周动脉粥样硬化的程度，利用彩色多普勒超声诊断仪和动脉硬化检测仪可以较容易得到这些参数，是评价外周动脉粥样硬化病变一种简便、易行，有临床实际意义的方法和手段。

Citation： WU Jichuan,LIU Tianhu,GUO Huali,YANG Jing,WANG Hongyu. Application of Arterial Stiffness and Ankle Brachial Index in Evaluating Peripheral Arteriosclerosis in Elderly Patients with Type 2 Diabetes. West China Medical Journal, 2012, 27(5): 662-664. doi: Copy

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1. 　王宏宇. 血管病学[M].北京:人民军医出版社, 2006.
2. 　Shenkin SD，Bastin ME，MacGillivray TJ, et al. Carotid intima-media thickness and cerebrovascular disease in community- dwelling older people without stroke[J]. Stroke, 2010, 41(9): 2083-2086.
3. 　曾华锋，赵小林，余红丽, 等. 2型糖尿病颈动脉内膜中层病变及相关危险因素分析[J].中国医药导报, 2011, 8(34): 44-46.
4. 　Grobbee DE, Bots ML. Carotid artery intima-media thickness as an indicator of generalized atherosclerosis[J]. J Intern Med, 1994, 236(5): 567-573.
5. 　Pignoli P, Tremohi E, Po1i A, et al. Intima plus medical thickness of the arterial wall: a direct measurement with ultrasound imaging[J].Circulation, 1986, 74(6): 1399-1406.
6. 　Bonithon-Kopp C, Touboul PJ, Berr C, et al. Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The vascular aging (EVA) study[J]. Arterioscler Thromb Vasc Riol, 1996, 16(2): 310-316.
7. 　胡大一, 王宏宇. 主动脉僵硬度与急性冠脉事件[J]. 中国医刊, 2002, 37(5): 4-5.
8. 　向林,向光大. 脉搏波传导速度与糖尿病血管病变关系研究进展[J]. 临床内科杂志, 2010, 27(8): 574-576.
9. 　Asmar R, Benetos A, Topoucfiian J, et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement.Validation and clinical application studies[J]. Hypertension, 1995, 26(3): 485-490.
10. 　钟冕, 陈润钿, 黄沽明, 等. 影响臂踝脉搏波传导速度的临床多因素分析[J]. 现代预防医学, 2009, 36(20): 3820-3822 .
11. 　胡绍文, 郭瑞林. 实用糖尿病学[M]. 北京: 人民军医出版社, 2003.
12. 　Ouriel K. Peripheral arterial disease[J]. Lancet, 2001, 358(9289): 1257-1264.
13. 　Peter S. Peripheral arterial disease in people with diabetes: consensus statement recommendsscreening[J]. Clin Diabetes, 2004, 22(4): 179-180 .
14. 　Hasimu B, Li J, Nakayama T, et a1. Ankle braehial index as a marker of atheroselerosis in Chinese patients with high cardiovascular risk[J]. Hypertens Res, 2006, 29(1): 23-28.

West China Medical Journal

Application of Arterial Stiffness and Ankle Brachial Index in Evaluating Peripheral Arteriosclerosis in Elderly Patients with Type 2 Diabetes

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