The Influence of Neo-adjuvant Chemotherapy on the Chemokine Level in Patients with Colorectal Neoplasms_West China Medical Journal

Authors：

WANG Bin ^1,2 , TANG Zhiyun ^1,2 , PENG Chihan ^1,2 , WANG Xiaodong ^2,3 ,  LI Li ^2,3

1. West China Medical School; 2. MCQ Team, West China Hospital; 3. Gastrointestinal Department Surgery Center, West China Hospital; Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LI Li, Email: wb90113@163.com

Keywords：

新辅助化学疗法; 结直肠肿瘤; 炎症趋化因子

Video：

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目的　探讨新辅助化学疗法（化疗）对结直肠癌手术患者炎症因子水平的影响。方法　回顾2008年1月－2009年12月诊断为结直肠癌的487例患者的临床资料，剔除不符合研究条件者后，共390例，以是否接受过新辅助化疗分为术前化疗组（化疗组）156例与对照组234例进行研究。分别比较两组在入院时、术前、术后的炎症因子水平。结果　入院时两组外周血白细胞、C反应蛋白（CRP）、纤维蛋白原、血清淀粉样蛋白水平差异均无统计学意义（P＞0.05）；术后化疗组CRP水平[（64.09 ± 60.24）mg/L]低于对照组[（87.80 ± 61.54）mg/L]，差异有统计学意义（P＜0.05）；其余炎症因子组间差异无统计学意义（P＞0.05）。结论　新辅助化疗不会刺激机体产生免疫反应，且有一定的安全性。

Citation： WANG Bin,TANG Zhiyun,PENG Chihan,WANG Xiaodong,LI Li. The Influence of Neo-adjuvant Chemotherapy on the Chemokine Level in Patients with Colorectal Neoplasms. West China Medical Journal, 2012, 27(5): 697-700. doi: Copy

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15.	Scott HR, McMillan DC, Forrest LM, et al. The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer[J ]. Br J Cancer, 2002, 87(3): 264-267.
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17.	Palumbo JS, Kombrinck KW, Drew AF, et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells[J ]. Blood, 2000, 96(10): 3302-3309.
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22.	汪晓东, 邓磊, 吕东昊, 等. 结直肠癌患者术前SAA、CRP、CEA 和 CA1929 水平的临床诊断价值[J]. 四川医学, 2009, 30(3): 340-342.
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1. 　Quasar Collaborative Group, Gray R, Barnwell J, et al. Adjuvant chemotherapy versus observation in patients with colorectalcancer: a randomised study [J]. Lancet, 2007, 370(9604): 2020-2029.
2. 　National Comprehensive Cancer Network. Practice guidelines in oncology-rectal cancer. Version 2 [EB/OL]. http://www.NCCN.org. 2008.
3. 　Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual[M]. New York: Springer Verlag, 2002: 113-124.
4. 　吕东昊, 汪晓东, 阳川华, 等. 结直肠肿瘤多学科协作诊治模式的数据库初期建设现状[J]. 中国普外基础与临床杂志, 2007, 14(6): 713-715.
5. 　National Comprehensive Cancer Network. Clinical practice guidelines in oncology, colon cancer[EB/OL]. http://www.NCCN.org, 2010.
6. 　Copeland EM 3rd, Daly JM, Ota DM, et al. Nutrition, cancer, and intravenous hyperalimentation [J]. Cancer, 1979, 43(Suppl 5): 2108-2116.
7. 　李立, 汪晓东, 舒晔, 等. 四川大学华西医院·结直肠癌手术治疗指南[J]. 中国普外基础与临床杂志, 2008, 15(10-11): 778-942.
8. 　Frei E 3rd. Clinical cancer research: an embattled species[J]. Cancer, 1982, 50(10): 1979-1992．.
9. 　汪晓东, 刘丹, 吕东昊, 等. 结直肠癌血清纤维蛋白原和炎性介质、肿瘤标志物的术前诊断价值[J]. 肿瘤防治研究, 2010, 37(5): 566-569.
10. 　Yip HK, Wu CJ, Chang HW, et al. Levels and values of in flamm atory markers in patients with angina pectoris[J]. Int Heart J, 2005, 46(4): 571-581.
11. 　Nozoe T, Matsumata T, Kitamura M, et al. Significance of preoperative elevation of serum C-reactive protein as an indicator for prognosis in colorectal cancer [J]. Am J Surg, 1998, 176(4): 335-338.
12. 　Fujikawa K, Matsui Y, Oka H, et al. Serum C reactive protein level and the impact of cytoreductive surgery in patients with metastatic renal cell carcinoma[J]. Urology, 1999, 162(6): 1934-1937.
13. 　Michaeil A, Finci-Yeheskel Z, Dishon S, et al. Serum amyloid A enhances plasminogen activation: implication for a role in colon cancer[J]. Biochem Biophys Res Commun, 2008, 368(2): 368-373.
14. 　TillettW S, Francis T. Serological reactions in pneumonia with a non-protein somatic fraction of pneum ococcus [J]. J ExpMed, 1930, 52(4): 561-571.
15. 　Scott HR, McMillan DC, Forrest LM, et al. The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer[J ]. Br J Cancer, 2002, 87(3): 264-267.
16. 　Scott HR, McMillan DC, Brown DJ, et al. A prospective study of the impact of weight loss and the systemic inflammatory response on quality of life in patients with inoperable non-small cell lung cancer [J]. Lung Cancer, 2003, 40(3): 295-299.
17. 　Palumbo JS, Kombrinck KW, Drew AF, et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells[J ]. Blood, 2000, 96(10): 3302-3309.
18. 　Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperativeradiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial[J]. Lancet, 373(9666): 811-820.
19. 　Chan DC, Chen CJ, Chu HC, et al. Evaluation of serum amyloid A as a biomarker for gastric cancer [J]. Ann Surg Oncol, 2007, 14(1): 84-93.
20. 　Gutfeld O, Prus D, Ackerman Z, et al. Expression of serum amyloid A, in normal, dysplastic, and neoplastic human colonic mucosa: implication for a role in colonic tumorigenesis[J]. J Histochem Cytochem, 2006, 54(1): 63-73.
21. 　汪晓东, 吕东昊, 高命, 等. 结直肠癌患者术前血清CRP与SAA 检测的意义[J]. 中国肿瘤, 2009, 18(5): 416-419.
22. 　汪晓东, 邓磊, 吕东昊, 等. 结直肠癌患者术前SAA、CRP、CEA 和 CA1929 水平的临床诊断价值[J]. 四川医学, 2009, 30(3): 340-342.
23. 　Yoon SM, Kim DY, Kim TH, et al. Clinical parameters predictiong pathologic tumor response after preoperative chemoradiotherapy for rectal cancer[J]. Int J Radiat Oncol Biol Phys, 2007, 69(4): 1167.

West China Medical Journal

The Influence of Neo-adjuvant Chemotherapy on the Chemokine Level in Patients with Colorectal Neoplasms

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