Clinical Research of IgA Nephropathy Associated with Hyperuricemia in Different Gender_West China Medical Journal

Authors：

JIANG Yirong ¹ , WEN Ji ¹ , ZHANG Chenglong ¹ ,  FAN Junming ^1,2

1. Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China; 2. Department of Nephrology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

FAN Junming, Email: jiangyirong517@163.com

Keywords：

IgA肾病; 高尿酸血症; 性别

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目的　探讨不同性别IgA肾病患者合并高尿酸血症的临床及肾脏病理特点。方法　采用回顾性研究方法，将2008年1月－2010年12月收治的226例经肾活检确诊的原发性IgA肾病患者分为男性高尿酸血症组、男性尿酸正常组、女性高尿酸血症组及女性尿酸正常组4组，统计分析4组的临床指标及病理指标。结果　高尿酸血症患病率男性（21.7%）高于女性（11.9%），差异有统计学意义（P＜0.01），尿检异常型患病率男性（14.6%）高于女性（4.0%），差异有统计学意义（P＜0.01），女性LeeⅢ级的患病率（7.1%）高于男性（5.8%），差异有统计学意义（P＜0.01）；男性高尿酸血症组的尿素氮高于尿酸正常组（P＜0.05），女性高尿酸血症组的血尿素氮、血肌酐、胱抑素C、舒张压、甘油三酯比尿酸正常者明显增高（P＜0.01），女性高尿酸血症组的高密度脂蛋白明显高于男性组（P ＜0.01）。结论　高尿酸血症是IgA肾病的危险因素，可导致更严重的肾功能损害及肾脏病理损害，这种影响在不同性别中存在差异。

Citation： JIANG Yirong,WEN Ji,ZHANG Chenglong,FAN Junming. Clinical Research of IgA Nephropathy Associated with Hyperuricemia in Different Gender. West China Medical Journal, 2012, 27(6): 833-836. doi: Copy

1.	Mcgrogan A, Franssen CF, de Vries CS. The incidence of primary glomerulonephritis worldwide： a systemic review of the literature [J].Nephrol Dial Transplant, 2011, 26(2): 414-430.
2.	Woo KT, Chan CM, Mooi CY, et al. The changing pattern of primary glomerulonephritis in Singapore and other countries over the past 3 decades[J]. Clin Nephrol, 2010, 74(5): 373-384.
3.	范军芬, 张史昭, 鲁科达, 等. IgA肾病伴高尿酸血症患者流行病学及临床病理分析[J].临床医学, 2008, 28(2): 103-104.
4.	姜雪, 许菲菲, 章建娜, 等. IgA肾病并发高尿酸血症患者5年随访研究[J].中华肾脏病杂志, 2011, 27(1): 53-54.
5.	Ghani AA, Al Waheeb S, Al Homoud E, et al. Clinical and histopathological spectrum of IgA nephropathy in Kuwait[J]. Ann Saudi Med, 2011, 31(2): 152-157.
6.	Le W, Liang S, Hu Y, et al. Long-term renal survival and related risk factors in patients with IgA nephropathy: results from a cohort of 1155 cases in a Chinese adult population[J]. Nephrol Dial Transplant, 2012, 27(4): 1479-1485.
7.	中国医师协会心血管内科医师分会, 中国医师协会循证医学专业委员会.无症状高尿酸血症合并心血管疾病诊治建议中国专家共识[J] . 中国全科医学, 2010, 13(11): 1145-1149.
8.	张馨, 黎磊石, 孙晔, 等.不同类型IgA肾病的流行病学及临床特点分析[J].肾脏病与透析肾移植杂志, 2006, 15(4): 305-310.
9.	Lee SM, Rao VM, Franklin WA, et al. IgA nephropathy: morphologic predictors of progressive renal disease [J]. Hum Pathol, 1982, 13(4): 314-322.
10.	Ohno I. Relationship between hyperuricemia and chronic kidney disease [J]. Nucleos Necleot Nucl, 2011, 30(12): 1039-1044.
11.	Shi YJ, Chen W, Li ZB, et al. Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial[J]. Kidney Blood Press Res, 2012, 35(3): 153-160.
12.	Gersch C, Palii SP, Kim KM, et al. Inactivation of nitric oxide by uric acid[J]. Nucleos Necleot Nucl, 2008, 27(8):967-978.
13.	Albertoni G, Maquiqussa E, Pessoa E, et al. Soluble uric acid increases intracellular calcium through an angiotensinⅡ-dependent mechanism in immaortalized human mesangial cells[J]. Exp Biol Med, 2010, 235(7): 825-832.
14.	Hovind P, Rossing P, Johnson RJ, et al. Serum uric acid as a new player in the development of diabetic nephropathy[J]. J Ren Nutri, 2011, 21(1): 124-127.
15.	崔明姬, 张宝红, 肖庆飞, 等.高尿酸血症与IgA肾病临床病例的相关性分析[J].中华内科杂志, 2011, 50(8): 659-663.
16.	Seeman T, Pohl M, John U, et al. Ambulatory blood pressure, proteinuria and uric acid in children with IgA nephropathy and their correlation with histopathological findings[J]. Kidney Blood Press Res, 2008, 31(5): 337-342.

1. 　Mcgrogan A, Franssen CF, de Vries CS. The incidence of primary glomerulonephritis worldwide： a systemic review of the literature [J].Nephrol Dial Transplant, 2011, 26(2): 414-430.
2. 　Woo KT, Chan CM, Mooi CY, et al. The changing pattern of primary glomerulonephritis in Singapore and other countries over the past 3 decades[J]. Clin Nephrol, 2010, 74(5): 373-384.
3. 　范军芬, 张史昭, 鲁科达, 等. IgA肾病伴高尿酸血症患者流行病学及临床病理分析[J].临床医学, 2008, 28(2): 103-104.
4. 　姜雪, 许菲菲, 章建娜, 等. IgA肾病并发高尿酸血症患者5年随访研究[J].中华肾脏病杂志, 2011, 27(1): 53-54.
5. 　Ghani AA, Al Waheeb S, Al Homoud E, et al. Clinical and histopathological spectrum of IgA nephropathy in Kuwait[J]. Ann Saudi Med, 2011, 31(2): 152-157.
6. 　Le W, Liang S, Hu Y, et al. Long-term renal survival and related risk factors in patients with IgA nephropathy: results from a cohort of 1155 cases in a Chinese adult population[J]. Nephrol Dial Transplant, 2012, 27(4): 1479-1485.
7. 　中国医师协会心血管内科医师分会, 中国医师协会循证医学专业委员会.无症状高尿酸血症合并心血管疾病诊治建议中国专家共识[J] . 中国全科医学, 2010, 13(11): 1145-1149.
8. 　张馨, 黎磊石, 孙晔, 等.不同类型IgA肾病的流行病学及临床特点分析[J].肾脏病与透析肾移植杂志, 2006, 15(4): 305-310.
9. 　Lee SM, Rao VM, Franklin WA, et al. IgA nephropathy: morphologic predictors of progressive renal disease [J]. Hum Pathol, 1982, 13(4): 314-322.
10. 　Ohno I. Relationship between hyperuricemia and chronic kidney disease [J]. Nucleos Necleot Nucl, 2011, 30(12): 1039-1044.
11. 　Shi YJ, Chen W, Li ZB, et al. Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial[J]. Kidney Blood Press Res, 2012, 35(3): 153-160.
12. 　Gersch C, Palii SP, Kim KM, et al. Inactivation of nitric oxide by uric acid[J]. Nucleos Necleot Nucl, 2008, 27(8):967-978.
13. 　Albertoni G, Maquiqussa E, Pessoa E, et al. Soluble uric acid increases intracellular calcium through an angiotensinⅡ-dependent mechanism in immaortalized human mesangial cells[J]. Exp Biol Med, 2010, 235(7): 825-832.
14. 　Hovind P, Rossing P, Johnson RJ, et al. Serum uric acid as a new player in the development of diabetic nephropathy[J]. J Ren Nutri, 2011, 21(1): 124-127.
15. 　崔明姬, 张宝红, 肖庆飞, 等.高尿酸血症与IgA肾病临床病例的相关性分析[J].中华内科杂志, 2011, 50(8): 659-663.
16. 　Seeman T, Pohl M, John U, et al. Ambulatory blood pressure, proteinuria and uric acid in children with IgA nephropathy and their correlation with histopathological findings[J]. Kidney Blood Press Res, 2008, 31(5): 337-342.

West China Medical Journal

Clinical Research of IgA Nephropathy Associated with Hyperuricemia in Different Gender

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