放射及化学治疗所致口腔黏膜炎的护理_West China Medical Journal

Authors：

刘晓菊 ,  汪秀云

Corresponding author：

汪秀云, Email: lxj0506@163.com

Keywords：

口腔黏膜炎; 放射治疗; 化学治疗; 护理

Video：

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口腔黏膜炎是放射及化学治疗常见的不良反应，而口腔黏膜炎引起的继发反应，是影响患者生活质量的重要原因，所以对于口腔黏膜炎的护理非常重要。本文对放射及化学治疗引起口腔黏膜炎的护理进行了总结，以便于临床工作中医护人员正确评估患者的口腔，同时能够及时给予患者最佳的护理措施，进而提高患者的生活质量。

Citation： 刘晓菊,汪秀云. 放射及化学治疗所致口腔黏膜炎的护理. West China Medical Journal, 2012, 27(6): 938-940. doi: Copy

1.	Cawley MM, Benson LM. Current trend in managing oral mucositis clinical[J]. Clin J Oncol Nurs, 2005, 9(5): 584-592.
2.	Wright J. Chemotherapy- induced oralmucositis: new approaches to prevention and management[J]. Expert Opin Drug Saf, 2005, 4(2): 193-200.
3.	张文陆, 宇长青, 王言. 放化疗引起的OM的病理基础和诊断概况[J].医学综述, 2007, 13(18): 1388-1390.
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8.	Avritscher E, Cookley C, Elting L. Scope and epidemiology of cancer-therapy induced oral and gastrointestinalmucositis[J]. Semin Oncol Nursing, 2004, 20(1): 3-8.
9.	Wright J, Feld R. Knox J. Chemotherapy-inducedoralmucositis new approaches to prevention and management[ J]. Exper Opin Drug Saf, 2005, 4(2): 193-200.
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12.	徐慧颖, 李亚洁, 廖晓艳. OM评估量表及其应用研究[J]. 护理研究, 2008, 11(22): 2917-2918.
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16.	何为, 张玉莲, 梅慧, 等. 复方棒冰综合防治鼻咽癌患者放射性口腔黏膜反应的临床研究[J]. 中华护理杂志, 2006, 41(1): 20-23.
17.	张玲, 阎平, 韩丽娟, 等. 低温预防大剂量美法仑导致OM的临床观察[J]. 护理研究, 2010, 24(3B): 708-709.
18.	常韻芳. 粒细胞集落刺激因子雾化吸入治疗放射性OM的临床观察[J]. 中国当代医药, 2009, 16(3): 94.
19.	徐剑鸿. 头颈部肿瘤放疗中辅以雾化吸入的应用和护理[J]. 安徽预防医学杂志, 2006, 12(5): 346-347.
20.	王君艳, 纪玉梅, 王佳宏. 头颈部肿瘤放疗致口腔黏膜反应两种治疗方法比较[J]. 齐鲁护理杂志, 2007, 13(17): 66.
21.	谢松喜, 李伟雄, 陈应瑞. 口服谷氨酰胺治疗放射性OM的随机对照研究[J]. 重庆医学, 2005, 8(34): 1195-1196.
22.	窦慧芹，扈东艳，王秀问，等. 谷氨酰胺颗粒对化疗所致OM的疗效分析[J] . 山东大学学报, 2010, 48(7): 112-114.
23.	赵建国, 张凌, 项晓军, 等. 重组人粒细胞集落刺激因子预防放射性OM的临床观察[J]. 中国药房, 2010, 48(8): 4547-4548．.
24.	Schubert MM, Eduardo FP, Guthrie KA, et al. A phaseⅢrandomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositisin patients undergoing hematopoietic cell transplant ation[J]. Support Care Cancer, 2007, 15(10): 1145-1154.
25.	Colella G, Cannavale R, Vicidomini A. Efficacy of a spray compound containing a pool of collagen precursor synthetic aminoacids (l-proline, l-leucine, l-lysine and glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis: preliminary data of an open trial[J]. Int J Immuno pathol Pharmacol, 2010, 23(1):143-151.
26.	Vayne-Bossert P, Escher M, de Vautibault CG. Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: a randomized double-blinded study[J]. J Palliat Med, 2010, 13(2): 125-128.
27.	Blijlevens N, Sonis S. Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis[J]. Ann Oncol, 2007, 18(5): 817-826.

1. 　Cawley MM, Benson LM. Current trend in managing oral mucositis clinical[J]. Clin J Oncol Nurs, 2005, 9(5): 584-592.
2. 　Wright J. Chemotherapy- induced oralmucositis: new approaches to prevention and management[J]. Expert Opin Drug Saf, 2005, 4(2): 193-200.
3. 　张文陆, 宇长青, 王言. 放化疗引起的OM的病理基础和诊断概况[J].医学综述, 2007, 13(18): 1388-1390.
4. 　陈燕芳. 放化疗所致OM的护理研究现状[J]. 护理实践与研究2011, 8(3): 109-110.
5. 　Sonis ST. Oral mucositis in cancer therapy[J]. J Support Oncol, 2004, 2(Suppl 3): 3-8.
6. 　刘建红, 郑晓莉, 茅静, 等.化疗致OM的相关因素分析[J]. 2007, 22(17): 7-9.
7. 　Baladucci L, ExterrmanM. Management of cancer in the older person: a practical approach[J]. Oncologist, 2000, 20: 224-237.
8. 　Avritscher E, Cookley C, Elting L. Scope and epidemiology of cancer-therapy induced oral and gastrointestinalmucositis[J]. Semin Oncol Nursing, 2004, 20(1): 3-8.
9. 　Wright J, Feld R. Knox J. Chemotherapy-inducedoralmucositis new approaches to prevention and management[ J]. Exper Opin Drug Saf, 2005, 4(2): 193-200.
10. 　Quinna B, Carin M. J. Pottingb, R. Guidelines for the assessmentoforalmucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patient [J]. Eur J Cancer Care (Engl), 2008, 44: 61-72.
11. 　徐慧颖, 李亚洁, 廖晓艳. OM护理研究进展[J]. 护理研究, 2008, 22(6): 1505-1507.
12. 　徐慧颖, 李亚洁, 廖晓艳. OM评估量表及其应用研究[J]. 护理研究, 2008, 11(22): 2917-2918.
13. 　Eilers J. Nursing interventions and supportive care for the pre-vention and treatment of oral mucositis associated with cancer treatment[J]. 2004, 4(31): 13-23.
14. 　殷磊. 护理学基础[M]. 3版. 北京: 人民卫生出版社, 2005: 274.
15. 　朱国亚. 冰水含漱预防化疗后OM的护理观察[J]. 安徽预防医学杂志 , 2007, 13(4): 317-318.
16. 　何为, 张玉莲, 梅慧, 等. 复方棒冰综合防治鼻咽癌患者放射性口腔黏膜反应的临床研究[J]. 中华护理杂志, 2006, 41(1): 20-23.
17. 　张玲, 阎平, 韩丽娟, 等. 低温预防大剂量美法仑导致OM的临床观察[J]. 护理研究, 2010, 24(3B): 708-709.
18. 　常韻芳. 粒细胞集落刺激因子雾化吸入治疗放射性OM的临床观察[J]. 中国当代医药, 2009, 16(3): 94.
19. 　徐剑鸿. 头颈部肿瘤放疗中辅以雾化吸入的应用和护理[J]. 安徽预防医学杂志, 2006, 12(5): 346-347.
20. 　王君艳, 纪玉梅, 王佳宏. 头颈部肿瘤放疗致口腔黏膜反应两种治疗方法比较[J]. 齐鲁护理杂志, 2007, 13(17): 66.
21. 　谢松喜, 李伟雄, 陈应瑞. 口服谷氨酰胺治疗放射性OM的随机对照研究[J]. 重庆医学, 2005, 8(34): 1195-1196.
22. 　窦慧芹，扈东艳，王秀问，等. 谷氨酰胺颗粒对化疗所致OM的疗效分析[J] . 山东大学学报, 2010, 48(7): 112-114.
23. 　赵建国, 张凌, 项晓军, 等. 重组人粒细胞集落刺激因子预防放射性OM的临床观察[J]. 中国药房, 2010, 48(8): 4547-4548．.
24. 　Schubert MM, Eduardo FP, Guthrie KA, et al. A phaseⅢrandomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositisin patients undergoing hematopoietic cell transplant ation[J]. Support Care Cancer, 2007, 15(10): 1145-1154.
25. 　Colella G, Cannavale R, Vicidomini A. Efficacy of a spray compound containing a pool of collagen precursor synthetic aminoacids (l-proline, l-leucine, l-lysine and glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis: preliminary data of an open trial[J]. Int J Immuno pathol Pharmacol, 2010, 23(1):143-151.
26. 　Vayne-Bossert P, Escher M, de Vautibault CG. Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: a randomized double-blinded study[J]. J Palliat Med, 2010, 13(2): 125-128.
27. 　Blijlevens N, Sonis S. Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis[J]. Ann Oncol, 2007, 18(5): 817-826.

West China Medical Journal

放射及化学治疗所致口腔黏膜炎的护理

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