体外超声治疗对血栓性疾病的防治作用_West China Medical Journal

Authors：

潘红霞 ,  丁明甫

Corresponding author：

丁明甫, Email: phxia1024@126.com

Keywords：

血栓性疾病; 体外超声治疗

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卒中后患者以及脊髓损伤患者均为康复科住院患者中深静脉血栓（DVT）形成的高危人群。DVT的发生不仅影响患者肢体功能恢复，严重者还可引起肺栓塞，危及生命。静脉血栓的治疗包括药物治疗、介入治疗和手术治疗，但各种治疗均存在一定的不足和限制。无创性新技术以及新型抗凝溶栓药的开发显得格外重要。近年超声治疗学的发展，推动了体外超声治疗对于血栓性疾病作用的研究，是一种安全、有效的血栓预防治疗辅助方法。

Citation： 潘红霞,丁明甫. 体外超声治疗对血栓性疾病的防治作用. West China Medical Journal, 2012, 27(6): 953-956. doi: Copy

1.	Kong KH, Chua SG, Earnest A. Deep vein thrombosis in stroke patients admitted to a rehabilitation unit in Singapore[J]. Int J Stroke, 2009, 4(3): 175-179.
2.	Turpie AG. Prophylaxis of venous thromboembolism in stroke patients [J]. Semin Thromb Hemost, 1997, 23(2): 155-157.
3.	宋舟锋, 潘兵, 卢一生. 脊髓损伤后深静脉血栓栓塞的研究进展[J]. 颈腰痛杂志, 2012, 33(1): 59-61.
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5.	李艺, 王静. 老年髋关节损伤患者深静脉血栓预防的体会[J]. 新疆医学, 2011, 4l(1): 48-49.
6.	周虹. 骨科高危患者深静脉血栓的预防及护理[J]. 中国社区医师:医学专业, 2011, 13(7): 196-197.
7.	张锡平. 利伐沙班、低分子肝素、脉络舒通预防下肢全髋置换术后静脉血栓的疗效比较[J]. 中外医学研究, 2011, 9(18): 33-34.
8.	吴丹, 葛卫红, 于锋. 深静脉血栓的药物治疗研究进展[J]. 中国药房, 2011, 22(6): 560-562.
9.	任广兰. 防治血栓性疾病中的抗血小板药和抗凝血药[J]. 中国现代药物应用, 2011, 5(2): 155.
10.	Lippi G, Favaloro EJ, Cervellin G. Prevention of venous thromboembolism: focus on mechanical prophylaxis[J]. Semin Thromb Hemost, 2011, 37(3): 237-251.
11.	黎华珍. 间歇性充气压力泵对老年髋关节置换术后下肢深静脉血栓形成的影响[J]. 齐鲁护理杂志, 2011, 17(3): 40-41.
12.	延雅青, 库洪安. 气压式循环驱动器预防老年骨科术后下肢DVT效果观察及护理[J]. 齐鲁护理杂志, 2011, 17(5): 17-18.
13.	高金松, 袁立英, 王兵, 等. 循序减压弹力袜在普外科术后预防深静脉血栓形成的应用[J]. 中国实用医刊, 2010, 37(13): 44-45.
14.	谭春华, 文哲, 鲁道海. 足底动静脉泵在下肢骨折患者术后的应用[J]. 局解手术学杂志, 2011, 20(1): 60-61.
15.	JCS Joint Working Group. Guidelines for the diagnosis, treatment and prevention of pulmonary thromboembolism and deep vein thrombosis (JCS 2009)[J]. Circ J, 2011, 75(5): 1258-1281.
16.	童嘉毅, Mrochek AG, Stelmashok VI. 超声治疗血栓栓塞性疾病的研究进展[J]. 中华物理医学与康复杂志, 2006, 28(3): 208-210.
17.	严碧歌, 牛俊得. 医学超声治疗原理及其临床应用研究[J]. 现代生物医学进展, 2007, 7(8): 1246-1248.
18.	Blinc A, Francis CW, Trudnowski JL, et al. Characterization of ultrasound-potentiated fibrinolysis in vitro[J]. Blood, 1993, 81(10): 2636-2643.
19.	Harpaz D, Chen X, Francis CW, et al. Ultrasound accelerates uroki-nase-induced thrombolysis and reperfusion[J]. Am Heart J, 1994, 127(5): 1211-1219.
20.	周小煦, 吴建国. 低频超声体外消溶血栓的研究[J]. 实用医学杂志, 2007, 23(15): 2368-2370.
21.	Luo H, Steffen W, Cercek B, et al. Enhancement of thrombolysis by external ultrasound[J]. Am Heart J, 1993, 125(6): 1564-1569.
22.	贾如意, 沈学东, 李志善, 等. 超声波对犬股动脉血栓助溶作用的观察[J]. 中华物理医学杂志, 1998, 20(3): 14-16,69.
23.	Saguchi T, Onoue H, Urashima M, et al. Effective and safe conditions of low-frequency transcranial ultrasonic thrombolysis for acute ischemic stroke: neurologic and histologic evaluation in a rat middle cerebral artery stroke model[J]. Stroke, 2008, 39(3): 1007-1011.
24.	Nilsson AM, Odselius R, Roijer A, et al. Pro- and antifibrinolytic effects of ultrasound on streptokinase-induced thrombolysis[J]. Ultrasound Med Biol, 1995, 21(6): 833-840.
25.	Michael D, Marc F. Therapeutic ultrasound in ischemic stroke treatment: experimental evidence[J]. Eur J Ultrasound, 2002, 16(1-2): 121-130.
26.	王海清, 曹林生, 蒋小燕, 等. 体外治疗性超声对大鼠纤溶系统的影响[J]. 心脑血管病防治, 2003, 3(2): 18-19.
27.	贾如意, 殷洁, 岳文伟, 等. 体外治疗性超声对冠心病患者纤溶性的影响[J]. 心脏杂志, 2008, 20(3): 334-336.
28.	王怀新, 梁浩, 赵吉梅, 等. 体外超声助溶下肢深静脉血栓的近期疗效及其对凝血和纤溶的影响[J]. 中国医学工程, 2010, 18(1): 24-25, 27.
29.	王爱国, 王从政, 杨淑玲. 体外治疗性超声联合抗凝对左房内血栓的近期临床疗效观察[J]. 中国现代医生, 2010, 48(9): 153-155.
30.	董壮丽, 杨建国, 韩森楷, 等. 超声波治疗血栓性静脉炎的疗效观察[J]. 中国超声医学杂志, 1996, l2(7): 58-59.
31.	高连生, 郝树森, 陈稚丽, 等. 体外超声波治疗颈动脉粥样硬化斑块的临床研究[J]. 河北医药, 2010, 32(11): 1418-1419.
32.	Hitchcock KE, Holland CK. Ultrasound-assisted thrombolysis for stroke therapy: better thrombus break-up with bubbles[J]. Stroke, 2010, 41(10 Suppl): S50-S53.
33.	Nedelmann M, Eicke BM, Lierke EG, et al. Low-Frequency ultrasound induces nonenzymatic thrombolysis in vitro[J]. J Ultrasound Med, 2002, 21(6): 649-656.
34.	Alexandrov AV. Ultrasound enhancement of fibrinolysis[J]. Stroke, 2009, 40(3 Suppl): S107-S110.
35.	Tsivgoulis G, Eggers J, Ribo M, et al. Safety and efficacy of ultrasound-enhanced thrombolysis: a comprehensive review and meta-analysis of randomized and nonrandomized studies[J]. Stroke, 2010, 41(2): 280-287.

1. 　Kong KH, Chua SG, Earnest A. Deep vein thrombosis in stroke patients admitted to a rehabilitation unit in Singapore[J]. Int J Stroke, 2009, 4(3): 175-179.
2. 　Turpie AG. Prophylaxis of venous thromboembolism in stroke patients [J]. Semin Thromb Hemost, 1997, 23(2): 155-157.
3. 　宋舟锋, 潘兵, 卢一生. 脊髓损伤后深静脉血栓栓塞的研究进展[J]. 颈腰痛杂志, 2012, 33(1): 59-61.
4. 　Australian and New Zealand Working Party on the Management and Prevention of Venous Thromboembolism. Prevention of venous thromboembolism: best practice guidelines for Australia and New Zealand[M]. 4th ed. Sydney: Health Education & Management Innovation, 2007.
5. 　李艺, 王静. 老年髋关节损伤患者深静脉血栓预防的体会[J]. 新疆医学, 2011, 4l(1): 48-49.
6. 　周虹. 骨科高危患者深静脉血栓的预防及护理[J]. 中国社区医师:医学专业, 2011, 13(7): 196-197.
7. 　张锡平. 利伐沙班、低分子肝素、脉络舒通预防下肢全髋置换术后静脉血栓的疗效比较[J]. 中外医学研究, 2011, 9(18): 33-34.
8. 　吴丹, 葛卫红, 于锋. 深静脉血栓的药物治疗研究进展[J]. 中国药房, 2011, 22(6): 560-562.
9. 　任广兰. 防治血栓性疾病中的抗血小板药和抗凝血药[J]. 中国现代药物应用, 2011, 5(2): 155.
10. 　Lippi G, Favaloro EJ, Cervellin G. Prevention of venous thromboembolism: focus on mechanical prophylaxis[J]. Semin Thromb Hemost, 2011, 37(3): 237-251.
11. 　黎华珍. 间歇性充气压力泵对老年髋关节置换术后下肢深静脉血栓形成的影响[J]. 齐鲁护理杂志, 2011, 17(3): 40-41.
12. 　延雅青, 库洪安. 气压式循环驱动器预防老年骨科术后下肢DVT效果观察及护理[J]. 齐鲁护理杂志, 2011, 17(5): 17-18.
13. 　高金松, 袁立英, 王兵, 等. 循序减压弹力袜在普外科术后预防深静脉血栓形成的应用[J]. 中国实用医刊, 2010, 37(13): 44-45.
14. 　谭春华, 文哲, 鲁道海. 足底动静脉泵在下肢骨折患者术后的应用[J]. 局解手术学杂志, 2011, 20(1): 60-61.
15. 　JCS Joint Working Group. Guidelines for the diagnosis, treatment and prevention of pulmonary thromboembolism and deep vein thrombosis (JCS 2009)[J]. Circ J, 2011, 75(5): 1258-1281.
16. 　童嘉毅, Mrochek AG, Stelmashok VI. 超声治疗血栓栓塞性疾病的研究进展[J]. 中华物理医学与康复杂志, 2006, 28(3): 208-210.
17. 　严碧歌, 牛俊得. 医学超声治疗原理及其临床应用研究[J]. 现代生物医学进展, 2007, 7(8): 1246-1248.
18. 　Blinc A, Francis CW, Trudnowski JL, et al. Characterization of ultrasound-potentiated fibrinolysis in vitro[J]. Blood, 1993, 81(10): 2636-2643.
19. 　Harpaz D, Chen X, Francis CW, et al. Ultrasound accelerates uroki-nase-induced thrombolysis and reperfusion[J]. Am Heart J, 1994, 127(5): 1211-1219.
20. 　周小煦, 吴建国. 低频超声体外消溶血栓的研究[J]. 实用医学杂志, 2007, 23(15): 2368-2370.
21. 　Luo H, Steffen W, Cercek B, et al. Enhancement of thrombolysis by external ultrasound[J]. Am Heart J, 1993, 125(6): 1564-1569.
22. 　贾如意, 沈学东, 李志善, 等. 超声波对犬股动脉血栓助溶作用的观察[J]. 中华物理医学杂志, 1998, 20(3): 14-16,69.
23. 　Saguchi T, Onoue H, Urashima M, et al. Effective and safe conditions of low-frequency transcranial ultrasonic thrombolysis for acute ischemic stroke: neurologic and histologic evaluation in a rat middle cerebral artery stroke model[J]. Stroke, 2008, 39(3): 1007-1011.
24. 　Nilsson AM, Odselius R, Roijer A, et al. Pro- and antifibrinolytic effects of ultrasound on streptokinase-induced thrombolysis[J]. Ultrasound Med Biol, 1995, 21(6): 833-840.
25. 　Michael D, Marc F. Therapeutic ultrasound in ischemic stroke treatment: experimental evidence[J]. Eur J Ultrasound, 2002, 16(1-2): 121-130.
26. 　王海清, 曹林生, 蒋小燕, 等. 体外治疗性超声对大鼠纤溶系统的影响[J]. 心脑血管病防治, 2003, 3(2): 18-19.
27. 　贾如意, 殷洁, 岳文伟, 等. 体外治疗性超声对冠心病患者纤溶性的影响[J]. 心脏杂志, 2008, 20(3): 334-336.
28. 　王怀新, 梁浩, 赵吉梅, 等. 体外超声助溶下肢深静脉血栓的近期疗效及其对凝血和纤溶的影响[J]. 中国医学工程, 2010, 18(1): 24-25, 27.
29. 　王爱国, 王从政, 杨淑玲. 体外治疗性超声联合抗凝对左房内血栓的近期临床疗效观察[J]. 中国现代医生, 2010, 48(9): 153-155.
30. 　董壮丽, 杨建国, 韩森楷, 等. 超声波治疗血栓性静脉炎的疗效观察[J]. 中国超声医学杂志, 1996, l2(7): 58-59.
31. 　高连生, 郝树森, 陈稚丽, 等. 体外超声波治疗颈动脉粥样硬化斑块的临床研究[J]. 河北医药, 2010, 32(11): 1418-1419.
32. 　Hitchcock KE, Holland CK. Ultrasound-assisted thrombolysis for stroke therapy: better thrombus break-up with bubbles[J]. Stroke, 2010, 41(10 Suppl): S50-S53.
33. 　Nedelmann M, Eicke BM, Lierke EG, et al. Low-Frequency ultrasound induces nonenzymatic thrombolysis in vitro[J]. J Ultrasound Med, 2002, 21(6): 649-656.
34. 　Alexandrov AV. Ultrasound enhancement of fibrinolysis[J]. Stroke, 2009, 40(3 Suppl): S107-S110.
35. 　Tsivgoulis G, Eggers J, Ribo M, et al. Safety and efficacy of ultrasound-enhanced thrombolysis: a comprehensive review and meta-analysis of randomized and nonrandomized studies[J]. Stroke, 2010, 41(2): 280-287.

West China Medical Journal

体外超声治疗对血栓性疾病的防治作用

Abstract Full text Figures/Tables Video References Cited by

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