Application of Parecoxib Sodium on Patients Undergoing Procedure for Prolapse and Hemorrhoids for Preemptive Analgesia_West China Medical Journal

Authors：

XU Mingxing , ZHOU Hanmei

Department of Anesthesia, the Third People’s Hospital of Chengdu, Chengdu, Sichuan 610031, P. R. China;

Corresponding author：

Keywords：

帕瑞昔布; 丙泊酚; 超前镇痛; 半数有效效应室靶浓度; 痔上黏膜环切术

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目的　观察帕瑞昔布钠超前镇痛在痔上黏膜环切术中对丙泊酚半数有效效应室靶浓度和对术后视觉模拟评分法（VAS）的影响。方法　2010年3月－2011年10月择期手术患者60例，随机分为帕瑞昔布组（试验组）和生理盐水组（对照组），每组各30例，分别于术前10 min静脉注射帕瑞昔布钠40 mg或生理盐水2 mL。痔上黏膜环切时靶控输注丙泊酚，其靶控浓度按序贯法确定，相邻靶浓度之间对数差为0.05。观察两组丙泊酚的有效浓度及术后2、4、8、24 h的VAS评分。结果　试验组的半数有效效应室靶控浓度（4.30 μg/mL）低于对照组（4.95 μg/mL），差异有统计学意义（P＜0.05）。术后4、8、24 h试验组VAS评分明显低于对照组，差异有统计学意义（P＜0.05）。结论　帕瑞昔布钠可以减少术中丙泊酚的用量，并可得到满意的术后镇痛效果。

Citation： XU Mingxing,ZHOU Hanmei. Application of Parecoxib Sodium on Patients Undergoing Procedure for Prolapse and Hemorrhoids for Preemptive Analgesia. West China Medical Journal, 2012, 27(8): 1215-1217. doi: Copy

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11.	苏志源, 陈郡兴, 谭正玲, 等. 帕瑞昔布钠抑制瑞芬太尼术后痛觉过敏的量效关系[J]. 临床医学工程, 2011, 18(4): 528-529.
12.	杨程, 杨海基, 徐晓红, 等. 帕瑞昔布预防全麻术后躁动和咽喉痛的临床研究[J]. 实用药物与临床, 2012, 13(2): 105-106.

1. 　Gan TJ, Joshi GP, Zhao SZ, et al. Presurgical intravenous parecoxib Sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects[J]. Acta Anaesthesiol Scand, 2004, 48(9): 1194-1207.
2. 　Peck TE, Williams M, Hammond E. Pharmacology for anaesthesia and intensive care[M]. London: Greenwich Medical Media Ltd, 2000: 120-122.
3. 　Barton SF, Langeland FF, Snabes MC, et al. Efficacy and safety of intravenous parecoxib Sodium in relieving acute postoperative pain following gynecologic laparotomy surgery[J]. Anesthesiology, 2002, 97(2): 306-314.
4. 　杨树勤. 中国医学百科全书·医学统计学分册[M]. 上海: 上海科学技术出版社, 1985: 205.
5. 　Willis WD. Role of neurotransmitters in sensitization of pain responsers[J]. Ann NY Acad Sci, 2001, 933(2): 142.
6. 　蒋宗明, 陈忠华, 陈念平, 等. 帕瑞昔布钠超前镇痛对骨科患者术后血P物质、TNF-α和IL-6水平影响[J]. 河北医科大学学报, 2010, 31(4): 425-428.
7. 　Bajaj P, Ballary CC, Dongre NA, et al. Role of parecoxib in pre-emptive analgesia: comparison of the efficacy and safety of pre- and postoperative parecoxib in patients undergoing general surgery[J]. J Indian Med Assoc, 2004, 102(5): 272, 274, 276-278.
8. 　周桥灵, 张文璇, 杨承祥, 等. 帕瑞昔布钠超前镇痛对烧伤患者热休克蛋白70和白细胞介素-6水平的影响[J]. 临床麻醉学杂志, 2012, 28(1): 37-39.
9. 　Klaus H, Joke N, Hugo K VA, et al. Remifentanil directly activates human N-methyl-D-aspartate receptors expressed in xenopus laevis oocytes[J]. Anesthesiology, 2004, 100(6): 1531-1537.
10. 　Vincent J, Philippe R, Bruno G, et al. Remifentanil-induced post-operative hyperalgesia and its prevention with small-dose ketamine[J]. Anesthesiology, 2005, 103(1): 147-155.
11. 　苏志源, 陈郡兴, 谭正玲, 等. 帕瑞昔布钠抑制瑞芬太尼术后痛觉过敏的量效关系[J]. 临床医学工程, 2011, 18(4): 528-529.
12. 　杨程, 杨海基, 徐晓红, 等. 帕瑞昔布预防全麻术后躁动和咽喉痛的临床研究[J]. 实用药物与临床, 2012, 13(2): 105-106.

West China Medical Journal

Application of Parecoxib Sodium on Patients Undergoing Procedure for Prolapse and Hemorrhoids for Preemptive Analgesia

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